Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease - Wikidata - awgldk - TriplyDB

Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease

Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease

http://www.wikidata.org/entity/Q35721413

about

Autosomal dominant polycystic kidney disease: the last 3 years Role of calcium in polycystic kidney disease: From signaling to pathology Smelling the roses and seeing the light: gene therapy for ciliopathies Experimental therapies and ongoing clinical trials to slow down progression of ADPKD The role of the cilium in normal and abnormal cell cycles: emphasis on renal cystic pathologies Intraciliary calcium oscillations initiate vertebrate left-right asymmetry Physiological mechanisms and therapeutic potential of bone mechanosensing.Suggested Involvement of PP1/PP2A Activity and De Novo Gene Expression in Anhydrobiotic Survival in a Tardigrade, Hypsibius dujardini, by Chemical Genetic Approach Merging traditional Chinese medicine with modern drug discovery technologies to find novel drugs and functional foods Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and Opportunities Transient receptor potential (TRP) channels: a clinical perspective OWL reasoning framework over big biological knowledge network.Advances in the pathogenesis and treatment of polycystic kidney disease Ligand-based and structure-based investigation for Alzheimer's disease from traditional chinese medicine.Cyst formation in the PKD2 (1-703) transgenic rat precedes deregulation of proliferation-related pathways Polycystic kidney disease.Novel targets for the treatment of autosomal dominant polycystic kidney disease.Triptolide Inhibits the AR Signaling Pathway to Suppress the Proliferation of Enzalutamide Resistant Prostate Cancer Cells.The end game of chemical genetics: target identification.Triptolide as an Alternative to IVIG Therapy for Kawasaki Disease in a Mouse Model Activation of Trpv4 reduces the hyperproliferative phenotype of cystic cholangiocytes from an animal model of ARPKD.Triptolide reduces cyst formation in a neonatal to adult transition Pkd1 model of ADPKD Treatment strategies and clinical trial design in ADPKD Identification and validation of protein targets of bioactive small molecules Comparison of Tripterygium wilfordii Hook F versus sulfasalazine in the treatment of rheumatoid arthritis: a randomized trial.Triptolide inhibits proliferation and migration of colon cancer cells by inhibition of cell cycle regulators and cytokine receptors.Phosphonooxymethyl Prodrug of Triptolide: Synthesis, Physicochemical Characterization, and Efficacy in Human Colon Adenocarcinoma and Ovarian Cancer Xenografts.Hyaluronic acid prevents immunosuppressive drug-induced ovarian damage via up-regulating PGRMC1 expression.Cyclic AMP-mediated cyst expansion Pyrrolidine dithiocarbamate reduces the progression of total kidney volume and cyst enlargement in experimental polycystic kidney disease.Molecular pathways and therapies in autosomal-dominant polycystic kidney disease Vasopressin and disruption of calcium signalling in polycystic kidney disease.Ginkgolide B inhibits renal cyst development in in vitro and in vivo cyst models.An intelligent nano-antenna: Primary cilium harnesses TRP channels to decode polymodal stimuli The role of targeted chemical proteomics in pharmacology.Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates.Triptolide directly inhibits dCTP pyrophosphatase.Ion channels in renal disease.Effective therapy for nephritis in (NZB x NZW)F1 mice with triptolide and tripdiolide, the principal active components of the Chinese herbal remedy Tripterygium wilfordii Hook F.Vasopressin antagonists in polycystic kidney disease.

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Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease

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2007 nî lūn-bûn

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Proceedings of the National Academy of Sciences of the United States of America

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Triptolide is a traditional Ch ...... r of polycystic kidney disease

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Craig M Crews

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Dayne Okuhara

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Glen S Markowitz

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Joseph D Shotwell

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Stefan Somlo

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Zhiheng Yu

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P2860

Polycystin-2 is an intracellular calcium release channel

Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2

Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation

Potentiation and inhibition of Ca(2+) release-activated Ca(2+) channels by 2-aminoethyldiphenyl borate (2-APB) occurs independently of IP(3) receptors

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

The ion channel polycystin-2 is required for left-right axis determination in mice

Polycystin 1 is required for the structural integrity of blood vessels

PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2

The Caenorhabditis elegans autosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway

The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia

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4389-4394

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104

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2007-03-06T00:00:00Z

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6445774

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17360534

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1838612

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