New oral thiazolidinedione antidiabetic agents act as insulin sensitizers.
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MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazoneMetformin and metabolic diseases: a focus on hepatic aspectsIdentification of a novel mitochondrial protein ("mitoNEET") cross-linked specifically by a thiazolidinedione photoprobeThe CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity peroxisome proliferator-activated receptor ligandsThiazolidinediones: a new class of antidiabetic drugs.Facile transfer of [2Fe-2S] clusters from the diabetes drug target mitoNEET to an apo-acceptor proteinBlood pressure lowering by pioglitazone. Evidence for a direct vascular effect.NADPH inhibits [2Fe-2S] cluster protein transfer from diabetes drug target MitoNEET to an apo-acceptor protein.Thiazolidinediones and insulin resistance: peroxisome proliferatoractivated receptor gamma activation stimulates expression of the CAP geneAntidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytesDiscovery and development of selective PPAR gamma modulators as safe and effective antidiabetic agents.Clinical relevance of target identity and biology: implications for drug discovery and development.Mitochondrial target of thiazolidinediones.The TZD insulin sensitizer clue provides a new route into diabetes drug discovery.New treatments for patients with type 2 diabetes mellitusDrugs on the horizon for treatment of type 2 diabetes.Drugs and insulin resistance: clinical methods of evaluation and new pharmacological approaches to metabolism.Pioglitazone alters monocyte populations and stimulates recent thymic emigrants in the BBDZR/Wor type 2 diabetes rat model.Pioglitazone increases apolipoprotein A-I production by directly enhancing PPRE-dependent transcription in HepG2 cells.Insulin sensitizing pharmacology of thiazolidinediones correlates with mitochondrial gene expression rather than activation of PPAR gamma.Endocrine and metabolic effects of octreotide, a somatostatin analogue, in lean PCOS patients with either hyperinsulinaemia or lean normoinsulinaemia.Antidiabetic agent pioglitazone enhances adipocyte differentiation of 3T3-F442A cells.Cardioprotection with pioglitazone is abolished by nitric oxide synthase inhibitor in ischemic rabbit hearts--comparison of the effects of pioglitazone and metformin.The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster.Insulin sensitizers in 2013: new insights for the development of novel therapeutic agents to treat metabolic diseases.Novel PPARgamma agonists GI 262570, GW 7845, GW 1929, and pioglitazone decrease calcium channel function and myogenic tone in rat mesenteric arteries.What has prevented the expansion of insulin sensitisers?Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson's disease.Rosiglitazone prevents the onset of hyperglycaemia and proteinuria in the Zucker diabetic fatty rat.57th American Diabetes Association annual meeting.Thiazolidinediones inhibit the progression of established hypertension in the Dahl salt-sensitive rat.Troglitazone and metformin, but not glibenclamide, decrease blood pressure in Otsuka Long Evans Tokushima Fatty rats.Troglitazone combination therapy in obese type 2 diabetic patients poorly controlled with alpha-glucosidase inhibitors.Insulin and polycystic ovary syndrome: a new look at an old subject.Section Review: Oncologic, Endocrine & Metabolic: Thiazolidinediones
P2860
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P2860
New oral thiazolidinedione antidiabetic agents act as insulin sensitizers.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
New oral thiazolidinedione antidiabetic agents act as insulin sensitizers.
@ast
New oral thiazolidinedione antidiabetic agents act as insulin sensitizers.
@en
type
label
New oral thiazolidinedione antidiabetic agents act as insulin sensitizers.
@ast
New oral thiazolidinedione antidiabetic agents act as insulin sensitizers.
@en
prefLabel
New oral thiazolidinedione antidiabetic agents act as insulin sensitizers.
@ast
New oral thiazolidinedione antidiabetic agents act as insulin sensitizers.
@en
P1433
P1476
New oral thiazolidinedione antidiabetic agents act as insulin sensitizers.
@en
P2093
P304
P356
10.2337/DIACARE.15.8.1075
P407
P577
1992-08-01T00:00:00Z