Human-mouse cystic fibrosis transmembrane conductance regulator (CFTR) chimeras identify regions that partially rescue CFTR-ΔF508 processing and alter its gating defect.

Human-mouse cystic fibrosis transmembrane conductance regulator (CFTR) chimeras identify regions that partially rescue CFTR-ΔF508 processing and alter its gating defect.

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http://www.wikidata.org/entity/Q35734877
Allosteric coupling between the intracellular coupling helix 4 and regulatory sites of the first nucleotide-binding domain of CFTRThe silent codon change I507-ATC->ATT contributes to the severity of the ΔF508 CFTR channel dysfunctionImpact of the F508del mutation on ovine CFTR, a Cl- channel with enhanced conductance and ATP-dependent gating.Mutating the Conserved Q-loop Glutamine 1291 Selectively Disrupts Adenylate Kinase-dependent Channel Gating of the ATP-binding Cassette (ABC) Adenylate Kinase Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and Reduces Channel Function inThermal instability of ΔF508 cystic fibrosis transmembrane conductance regulator (CFTR) channel function: protection by single suppressor mutations and inhibiting channel activityCFTR mutations altering CFTR fragmentation.Altering intracellular pH reveals the kinetic basis of intraburst gating in the CFTR Cl- channel.Interference with ubiquitination in CFTR modifies stability of core glycosylated and cell surface pools.Revertant mutants modify, but do not rescue, the gating defect of the cystic fibrosis mutant G551D-CFTR.Allosteric modulation balances thermodynamic stability and restores function of ΔF508 CFTR.Potentiators exert distinct effects on human, murine, and Xenopus CFTR.Membrane protein stability can be compromised by detergent interactions with the extramembranous soluble domains
P2860

Human-mouse cystic fibrosis transmembrane conductance regulator (CFTR) chimeras identify regions that partially rescue CFTR-ΔF508 processing and alter its gating defect.

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http://www.wikidata.org/entity/Q35734877
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2011 nî lūn-bûn
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2011年の論文
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2011年論文
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2011年論文
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2011年論文
@zh-hk
2011年論文
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2011年論文
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2011年论文
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2011年论文
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2011年论文
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Human-mouse cystic fibrosis tr ...... g and alter its gating defect.
@ast
Human-mouse cystic fibrosis tr ...... g and alter its gating defect.
@en
type
label
Human-mouse cystic fibrosis tr ...... g and alter its gating defect.
@ast
Human-mouse cystic fibrosis tr ...... g and alter its gating defect.
@en
prefLabel
Human-mouse cystic fibrosis tr ...... g and alter its gating defect.
@ast
Human-mouse cystic fibrosis tr ...... g and alter its gating defect.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P921
P932
P356
P1433
P1476
Human-mouse cystic fibrosis tr ...... g and alter its gating defect.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P921
P932