Inhibition of Shp2 suppresses mutant EGFR-induced lung tumors in transgenic mouse model of lung adenocarcinoma. - Wikidata - awgldk - TriplyDB

Inhibition of Shp2 suppresses mutant EGFR-induced lung tumors in transgenic mouse model of lung adenocarcinoma.

Inhibition of Shp2 suppresses mutant EGFR-induced lung tumors in transgenic mouse model of lung adenocarcinoma.

http://www.wikidata.org/entity/Q35742500

about

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases Simple and rapid determination of homozygous transgenic mice via in vivo fluorescence imaging.Identification of novel candidate drivers connecting different dysfunctional levels for lung adenocarcinoma using protein-protein interactions and a shortest path approach PTPRO represses ERBB2-driven breast oncogenesis by dephosphorylation and endosomal internalization of ERBB2 Shp2 Inhibits Proliferation of Esophageal Squamous Cell Cancer via Dephosphorylation of Stat3 Shp2 Plays a Critical Role in IL-6-Induced EMT in Breast Cancer Cells.SHP2 overexpression enhances the invasion and metastasis of ovarian cancer in vitro and in vivo.Preclinical Modeling of KIF5B-RET Fusion Lung Adenocarcinoma.Overexpression of major CDKN3 transcripts is associated with poor survival in lung adenocarcinoma Targeted nanoconjugate co-delivering siRNA and tyrosine kinase inhibitor to KRAS mutant NSCLC dissociates GAB1-SHP2 post oncogene knockdown Genetic defects of the IRF1-mediated major histocompatibility complex class I antigen presentation pathway occur prevalently in the JAK2 gene in non-small cell lung cancer.Dietary quercetin potentiates the antiproliferative effect of interferon-α in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase.

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Inhibition of Shp2 suppresses mutant EGFR-induced lung tumors in transgenic mouse model of lung adenocarcinoma.

http://www.wikidata.org/entity/Q35742500

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Inhibition of Shp2 suppresses ...... model of lung adenocarcinoma.

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Eric B Haura

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Harshani R Lawrence

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Jie Wu

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Liwei Chen

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Qingling Huang

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Valentina E Schneeberger

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Yuan Ren

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P2860

Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2

Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor

Somatic mutations affect key pathways in lung adenocarcinoma

Development of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitors

Novel mutant-selective EGFR kinase inhibitors against EGFR T790M

Salicylic Acid Based Small Molecule Inhibitor for the Oncogenic Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2)

The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies.

Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors

Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia

Epidermal growth factor receptor mutations in lung cancer

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