Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia. - Wikidata - awgldk - TriplyDB

Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia.

Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia.

http://www.wikidata.org/entity/Q35742745

about

Non-coding RNA ANRIL and the number of plexiform neurofibromas in patients with NF1 microdeletions The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability DNA Methylation and Chromatin Remodeling: The Blueprint of Cancer Epigenetics Early Life Adverse Environmental Exposures Increase the Risk of Uterine Fibroid Development: Role of Epigenetic Regulation Epigenetic modulators, modifiers and mediators in cancer aetiology and progression Targeting EZH2 in cancer Histone acetylation: novel target for the treatment of acute lymphoblastic leukemia EZH2 in normal hematopoiesis and hematological malignancies Mutation of chromatin modifiers; an emerging hallmark of germinal center B-cell lymphomas Mechanisms of epigenetic regulation of leukemia onset and progression Redefining ALL classification: toward detecting high-risk ALL and implementing precision medicine Chromatin targeting drugs in cancer and immunity Myeloid malignancies: mutations, models and management From fly wings to targeted cancer therapies: a centennial for notch signaling Chromatin signatures of cancer Gain-of-function mutation of chromatin regulators as a tumorigenic mechanism and an opportunity for therapeutic intervention Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance.Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2 The molecular profile of adult T-cell acute lymphoblastic leukemia: mutations in RUNX1 and DNMT3A are associated with poor prognosis in T-ALL.Emerging concepts of epigenetic dysregulation in hematological malignancies Targeted sequencing identifies associations between IL7R-JAK mutations and epigenetic modulators in T-cell acute lymphoblastic leukemia The methyltransferases enhancer of zeste homolog (EZH) 1 and EZH2 control hepatocyte homeostasis and regeneration Control of embryonic stem cell identity by BRD4-dependent transcriptional elongation of super-enhancer-associated pluripotency genes Increasing Notch signaling antagonizes PRC2-mediated silencing to promote reprograming of germ cells into neurons Weaver Syndrome-Associated EZH2 Protein Variants Show Impaired Histone Methyltransferase Function In Vitro Occupying Chromatin: Polycomb Mechanisms for Getting to Genomic Targets, Stopping Transcriptional Traffic, and Staying Put Chimeric RNAs generated by intergenic splicing in normal and cancer cells.EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent.Gene set control analysis predicts hematopoietic control mechanisms from genome-wide transcription factor binding data.Large-scale quality analysis of published ChIP-seq data.Epigenetic control of immunity Ezh2 Acts as a Tumor Suppressor in Kras-driven Lung Adenocarcinoma.Targeting the PIM protein kinases for the treatment of a T-cell acute lymphoblastic leukemia subset Genome-wide mapping and characterization of Notch-regulated long noncoding RNAs in acute leukemia.Chromatin proteins and modifications as drug targets.Regulation and Role of EZH2 in Cancer Maturation stage of T-cell acute lymphoblastic leukemia determines BCL-2 versus BCL-XL dependence and sensitivity to ABT-199 A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells.EZH2 in normal and malignant hematopoiesis.MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia.

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P2860

Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia.

http://www.wikidata.org/entity/Q35742745

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2012 nî lūn-bûn

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2012年论文

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2012年论文

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Genetic inactivation of the po ...... acute lymphoblastic leukemia.

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Genetic inactivation of the po ...... acute lymphoblastic leukemia.

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Genetic inactivation of the po ...... acute lymphoblastic leukemia.

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Nature Medicine

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Genetic inactivation of the po ...... acute lymphoblastic leukemia.

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Adolfo Ferrando

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Dolors Ferres-Marco

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Filippo Utro

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Iannis Aifantis

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Isaura Rigo

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Jacob M Rowe

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Janis Racevskis

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Jasmin Siegle

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Jay Patel

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Jelena Nedjic

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P2860

Model-based analysis of ChIP-Seq (MACS)

c-Myc regulates transcriptional pause release

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin.

Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes.

High-resolution profiling of histone methylations in the human genome

A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila

SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex

Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells

Fast and accurate long-read alignment with Burrows-Wheeler transform

The Polycomb complex PRC2 and its mark in life

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298-301

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10.1038/NM.2651

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2

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18

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Aristotelis Tsirigos

Pieter Van Vlierberghe

Kim De Keersmaecker

Maria Dominguez

Francoise Pflumio

Elisabeth Paietta

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2012-02-06T00:00:00Z

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