Molecular determinant of ion selectivity of a (Na+ + K+)-coupled rat brain glutamate transporter
about
Sulfhydryl modification of V449C in the glutamate transporter EAAT1 abolishes substrate transport but not the substrate-gated anion conductanceMechanisms of glutamate transportMolecular dynamics simulations of the mammalian glutamate transporter EAAT3Crystal structure of a substrate-free aspartate transporterAmyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacityDynamic equilibrium between coupled and uncoupled modes of a neuronal glutamate transporterStructure of a glutamate transporter homologue from Pyrococcus horikoshii.Critical role of serine 465 in isoflurane-induced increase of cell-surface redistribution and activity of glutamate transporter type 3.Time-resolved mechanism of extracellular gate opening and substrate binding in a glutamate transporter.Structural features of the glutamate transporter familyDisulfide cross-linking of transport and trimerization domains of a neuronal glutamate transporter restricts the role of the substrate to the gating of the anion conductanceSinorhizobium meliloti dctA mutants with partial ability to transport dicarboxylic acids.Molecular dynamics simulations elucidate the mechanism of proton transport in the glutamate transporter EAAT3A conserved methionine residue controls the substrate selectivity of a neuronal glutamate transporter.The accessibility in the external part of the TM5 of the glutamate transporter EAAT1 is conformationally sensitive during the transport cycle.New views of glutamate transporter structure and function: advances and challenges.Two serine residues of the glutamate transporter GLT-1 are crucial for coupling the fluxes of sodium and the neurotransmitterA conserved aspartate residue located at the extracellular end of the binding pocket controls cation interactions in brain glutamate transportersDicarboxylate transport by rhizobia.Conserved asparagine residue located in binding pocket controls cation selectivity and substrate interactions in neuronal glutamate transporter.Electrogenic glutamate transporters in the CNS: molecular mechanism, pre-steady-state kinetics, and their impact on synaptic signaling.Aspartate-444 is essential for productive substrate interactions in a neuronal glutamate transporter.Cysteine scanning mutagenesis of transmembrane helix 3 of a brain glutamate transporter reveals two conformationally sensitive positionsA conserved serine-rich stretch in the glutamate transporter family forms a substrate-sensitive reentrant loop.The equivalent of a thallium binding residue from an archeal homolog controls cation interactions in brain glutamate transporters.Regulation of glial glutamate transporters by C-terminal domains.Structure and allosteric inhibition of excitatory amino acid transporter 1.Substrates and non-transportable analogues induce structural rearrangements at the extracellular entrance of the glial glutamate transporter GLT-1/EAAT2.Substrate-induced rearrangements in glutamate-transporter homologs.Cysteine-scanning mutagenesis reveals a highly amphipathic, pore-lining membrane-spanning helix in the glutamate transporter GltT.Coupled, but not uncoupled, fluxes in a neuronal glutamate transporter can be activated by lithium ions.Proximity of two oppositely oriented reentrant loops in the glutamate transporter GLT-1 identified by paired cysteine mutagenesis.Cysteine-scanning mutagenesis reveals a conformationally sensitive reentrant pore-loop in the glutamate transporter GLT-1.A hydrophobic domain in glutamate transporters forms an extracellular helix associated with the permeation pathway for substrates.Is the glutamate residue Glu-373 the proton acceptor of the excitatory amino acid carrier 1?Arginine 445 controls the coupling between glutamate and cations in the neuronal transporter EAAC-1.The chloride permeation pathway of a glutamate transporter and its proximity to the glutamate translocation pathway.Characterization of hydrated Na+(phenol) and K+(phenol) complexes using infrared spectroscopy.The role of cation binding in determining substrate selectivity of glutamate transporters.Analysis of the quality of crystallographic data and the limitations of structural models.
P2860
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P2860
Molecular determinant of ion selectivity of a (Na+ + K+)-coupled rat brain glutamate transporter
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Molecular determinant of ion s ...... at brain glutamate transporter
@ast
Molecular determinant of ion s ...... at brain glutamate transporter
@en
type
label
Molecular determinant of ion s ...... at brain glutamate transporter
@ast
Molecular determinant of ion s ...... at brain glutamate transporter
@en
prefLabel
Molecular determinant of ion s ...... at brain glutamate transporter
@ast
Molecular determinant of ion s ...... at brain glutamate transporter
@en
P2093
P2860
P356
P1476
Molecular determinant of ion s ...... at brain glutamate transporter
@en
P2093
P2860
P304
P356
10.1073/PNAS.95.2.751
P407
P577
1998-01-01T00:00:00Z