Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress. - Wikidata - awgldk - TriplyDB

Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress.

Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress.

http://www.wikidata.org/entity/Q35750893

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Cytotoxic epipolythiodioxopiperazine alkaloids from filamentous fungi of the Bionectriaceae Redox-directed cancer therapeutics: molecular mechanisms and opportunities Mechanisms of epigenetic regulation of leukemia onset and progression Trials with 'epigenetic' drugs: an update Enantioselective total synthesis of plectosphaeroic acid B Enantioselective total syntheses of plectosphaeroic acids B and C.Chaetocin induces apoptosis in human melanoma cells through the generation of reactive oxygen species and the intrinsic mitochondrial pathway, and exerts its anti-tumor activity in vivo Chaetocin-induced ROS-mediated apoptosis involves ATM-YAP1 axis and JNK-dependent inhibition of glucose metabolism The anticancer agent chaetocin is a competitive substrate and inhibitor of thioredoxin reductase.Cytotoxic dimeric epipolythiodiketopiperazines from the ascomycetous fungus Preussia typharum Vascular injury involves the overoxidation of peroxiredoxin type II and is recovered by the peroxiredoxin activity mimetic that induces reendothelialization.Transcriptional repressive H3K9 and H3K27 methylations contribute to DNMT1-mediated DNA methylation recovery Epidithiodiketopiperazines (ETPs) exhibit in vitro antiangiogenic and in vivo antitumor activity by disrupting the HIF-1α/p300 complex in a preclinical model of prostate cancer.Current limitations and future opportunities for epigenetic therapies.General approach to epipolythiodiketopiperazine alkaloids: total synthesis of (+)-chaetocins A and C and (+)-12,12'-dideoxychetracin A Synthesis and Anticancer Activity of Epipolythiodiketopiperazine Alkaloids Epigenetic drugs against cancer: an evolving landscape.Enantioselective total synthesis of (+)-gliocladine C: convergent construction of cyclotryptamine-fused polyoxopiperazines and a general approach for preparing epidithiodioxopiperazines from trioxopiperazine precursors.Emerging role of linker histone variant H1x as a biomarker with prognostic value in astrocytic gliomas. A multivariate analysis including trimethylation of H3K9 and H4K20.BIX-01294 induces autophagy-associated cell death via EHMT2/G9a dysfunction and intracellular reactive oxygen species production.The anticancer effects of chaetocin are independent of programmed cell death and hypoxia, and are associated with inhibition of endothelial cell proliferation.Epigenetics in diagnosis, prognostic assessment and treatment of cancer: an update.Tricyclic Analogues of Epidithiodioxopiperazine Alkaloids with Promising In Vitro and In Vivo Antitumor Activity.A practical sulfenylation of 2,5-diketopiperazines.Concise Total Synthesis of (+)-Luteoalbusins A and B.p21(WAF1) gene promoter is epigenetically silenced by CTIP2 and SUV39H1.The histone 3 lysine 9 methyltransferase inhibitor chaetocin improves prognosis in a rat model of high salt diet-induced heart failure.Phosphorylation-mediated EZH2 inactivation promotes drug resistance in multiple myeloma.Synthesis and biological evaluation of epidithio-, epitetrathio-, and bis-(methylthio)diketopiperazines: synthetic methodology, enantioselective total synthesis of epicoccin G, 8,8'-epi-ent-rostratin B, gliotoxin, gliotoxin G, emethallicin E, and ha Improved therapeutic effect against leukemia by a combination of the histone methyltransferase inhibitor chaetocin and the histone deacetylase inhibitor trichostatin A.General approach for preparing epidithiodioxopiperazines from trioxopiperazine precursors: enantioselective total syntheses of (+)- and (-)-gliocladine C, (+)-leptosin D, (+)-T988C, (+)-bionectin A, and (+)-gliocladin A.HIV-1 transcription and latency: an update.The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness.Anti-rheumatoid Activity of Secondary Metabolites Produced by Endophytic Chaetomium globosum Chemical probes for histone-modifying enzymes High-resolution MS, MS/MS, and UV database of fungal secondary metabolites as a dereplication protocol for bioactive natural products.Epidithiodiketopiperazines block the interaction between hypoxia-inducible factor-1alpha (HIF-1alpha) and p300 by a zinc ejection mechanism.Direct inhibition of hypoxia-inducible transcription factor complex with designed dimeric epidithiodiketopiperazine.A combination treatment with DNA methyltransferase inhibitors and suramin decreases invasiveness of breast cancer cells NT1721, a novel epidithiodiketopiperazine, exhibits potent in vitro and in vivo efficacy against acute myeloid leukemia.

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P2860

Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress.

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2006 nî lūn-bûn

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Chaetocin: a promising new ant ...... mposition of oxidative stress.

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Chaetocin: a promising new ant ...... mposition of oxidative stress.

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Chaetocin: a promising new ant ...... mposition of oxidative stress.

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Crescent R Isham

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Jennifer D Tibodeau

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Keith C Bible

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Michael M Timm

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Ruifang Xu

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Wendy Jin

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P2860

Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway

Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 1.

Clinical experience with intravenous and oral formulations of the novel histone deacetylase inhibitor suberoylanilide hydroxamic acid in patients with advanced hematologic malignancies.

The late increase in intracellular free radical oxygen species during apoptosis is associated with cytochrome c release, caspase activation, and mitochondrial dysfunction.

Characterization of the MM.1 human multiple myeloma (MM) cell lines: a model system to elucidate the characteristics, behavior, and signaling of steroid-sensitive and -resistant MM cells.

ROS stress in cancer cells and therapeutic implications.

Arsenic trioxide sensitizes CD95/Fas-induced apoptosis through ROS-mediated upregulation of CD95/Fas by NF-kappaB activation.

Correlates of imexon sensitivity in human multiple myeloma cell lines.

Green tea component, catechin, induces apoptosis of human malignant B cells via production of reactive oxygen species.

Epigenetic silencing of manganese superoxide dismutase (SOD-2) in KAS 6/1 human multiple myeloma cells increases cell proliferation.

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