Highly diastereoselective and enantioselective olefin cyclopropanation using engineered myoglobin-based catalysts.
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Building Bridges: Biocatalytic C–C-Bond Formation toward Multifunctional ProductsHow a novel tyrosine-heme cross-link fine-tunes the structure and functions of heme proteins: a direct comparitive study of L29H/F43Y myoglobinBeyond Iron: Iridium-Containing P450 Enzymes for Selective Cyclopropanations of Structurally Diverse Alkenes.Myoglobin-catalyzed intermolecular carbene N-H insertion with arylamine substrates.Enzymatic C(sp(3))-H Amination: P450-Catalyzed Conversion of Carbonazidates into Oxazolidinones.Intermolecular carbene S-H insertion catalysed by engineered myoglobin-based catalysts†.Catalytic and Biocatalytic Iron Porphyrin Carbene Formation: Effects of Binding Mode, Carbene Substituent, Porphyrin Substituent, and Protein Axial Ligand.Interfacing microbial styrene production with a biocompatible cyclopropanation reactionEfficient conversion of primary azides to aldehydes catalyzed by active site variants of myoglobinMyoglobin-Catalyzed Olefination of AldehydesRational Design of Dual Active Sites in a Single Protein Scaffold: A Case Study of Heme Protein in Myoglobin.Genetic Optimization of Metalloenzymes: Enhancing Enzymes for Non-Natural Reactions.Exploiting and engineering hemoproteins for abiological carbene and nitrene transfer reactions.The Metal Drives the Chemistry: Dual Functions of Acireductone Dioxygenase.Identification of Mechanism-Based Inactivation in P450-Catalyzed Cyclopropanation Facilitates Engineering of Improved Enzymes.DNA-Accelerated Catalysis of Carbene-Transfer Reactions by a DNA/Cationic Iron Porphyrin HybridAldehyde and Ketone Synthesis by P450-Catalyzed Oxidative Deamination of Alkyl Azides.Engineering a dirhodium artificial metalloenzyme for selective olefin cyclopropanation.Mutating a Highly Conserved Residue in Diverse Cytochrome P450s Facilitates Diastereoselective Olefin Cyclopropanation.Biocatalytic Synthesis of Allylic and Allenyl Sulfides through a Myoglobin-Catalyzed Doyle-Kirmse Reaction.Highly Stereoselective Biocatalytic Synthesis of Key Cyclopropane Intermediate to Ticagrelor.Abiological catalysis by artificial haem proteins containing noble metals in place of iron.Directed evolution of cytochrome c for carbon-silicon bond formation: Bringing silicon to life.Catalyst-Controlled Site-Selective Bond Activation.Gram-Scale Synthesis of Chiral Cyclopropane-Containing Drugs and Drug Precursors with Engineered Myoglobin Catalysts Featuring Complementary Stereoselectivity.Cyclopropanations via Heme Carbenes: Basic Mechanism and Effects of Carbene Substituent, Protein Axial Ligand, and Porphyrin Substitution.Design of artificial metalloproteins/metalloenzymes by tuning noncovalent interactions.Enzyme stabilization via computationally guided protein stapling.C-H Insertions by Iron Porphyrin Carbene: Basic Mechanism and Origin of Substrate Selectivity.Orthogonal Expression of an Artificial Metalloenzyme for Abiotic Catalysis.Highly Diastereo- and Enantioselective Synthesis of Trifluoromethyl-Substituted Cyclopropanes via Myoglobin-Catalyzed Transfer of Trifluoromethylcarbene.Directed Evolution of Iridium-Substituted Myoglobin Affords Versatile Artificial Metalloenzymes for Enantioselective C-C Bond-Forming Reactions.Diverse Engineered Heme Proteins Enable Stereodivergent Cyclopropanation of Unactivated Alkenes.Metal Substitution Modulates the Reactivity and Extends the Reaction Scope of Myoglobin Carbene Transfer Catalysts.Stereoselective olefin cyclopropanation under aerobic conditions with an artificial enzyme incorporating an iron-chlorin e6 cofactor.An Artificial Heme Enzyme for Cyclopropanation Reactions.Biocatalytic oxidation reactions - a Chemist's perspective.Catalytic iron-carbene intermediate revealed in a cytochrome carbene transferaseHot off the pressDesigning ‘Totem’C2-Symmetrical Iron Porphyrin Catalysts for Stereoselective Cyclopropanations
P2860
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P2860
Highly diastereoselective and enantioselective olefin cyclopropanation using engineered myoglobin-based catalysts.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
Highly diastereoselective and ...... red myoglobin-based catalysts.
@ast
Highly diastereoselective and ...... red myoglobin-based catalysts.
@en
type
label
Highly diastereoselective and ...... red myoglobin-based catalysts.
@ast
Highly diastereoselective and ...... red myoglobin-based catalysts.
@en
prefLabel
Highly diastereoselective and ...... red myoglobin-based catalysts.
@ast
Highly diastereoselective and ...... red myoglobin-based catalysts.
@en
P2860
P356
P1476
Highly diastereoselective and ...... red myoglobin-based catalysts.
@en
P2093
Melanie Bordeaux
Vikas Tyagi
P2860
P304
P356
10.1002/ANIE.201409928
P407
P50
P577
2014-12-23T00:00:00Z