Increased reactive oxygen species production and lower abundance of complex I subunits and carnitine palmitoyltransferase 1B protein despite normal mitochondrial respiration in insulin-resistant human skeletal muscle

Increased reactive oxygen species production and lower abundance of complex I subunits and carnitine palmitoyltransferase 1B protein despite normal mitochondrial respiration in insulin-resistant human skeletal muscle

Item

http://www.wikidata.org/entity/Q35757202

Q35757202

about

The Emerging Role of Branched-Chain Amino Acids in Insulin Resistance and Metabolism Chemical Conditioning as an Approach to Ischemic Stroke Tolerance: Mitochondria as the Target Skeletal Muscle Mitochondrial Bioenergetics and Morphology in High Fat Diet Induced Obesity and Insulin Resistance: Focus on Dietary Fat Source Calcineurin inhibition and new-onset diabetes mellitus after transplantation Sources and implications of NADH/NAD(+) redox imbalance in diabetes and its complications Branched-chain amino acids in metabolic signalling and insulin resistance Effect of short-term thyroxine administration on energy metabolism and mitochondrial efficiency in humans The Janus Head of Oxidative Stress in Metabolic Diseases and During Physical Exercise.Adenine nucleotide translocase is acetylated in vivo in human muscle: Modeling predicts a decreased ADP affinity and altered control of oxidative phosphorylation.Staphylococcus aureus sepsis induces early renal mitochondrial DNA repair and mitochondrial biogenesis in mice.Mitochondrial complex I deficiency enhances skeletal myogenesis but impairs insulin signaling through SIRT1 inactivation.Skeletal muscle phosphodiester content relates to body mass and glycemic control.Effect of calcium on the oxidative phosphorylation cascade in skeletal muscle mitochondria Overfeeding reduces insulin sensitivity and increases oxidative stress, without altering markers of mitochondrial content and function in humans.Unraveling biochemical pathways affected by mitochondrial dysfunctions using metabolomic approaches.Disrupting mitochondrial-nuclear coevolution affects OXPHOS complex I integrity and impacts human health.Effects of acute exposure to increased plasma branched-chain amino acid concentrations on insulin-mediated plasma glucose turnover in healthy young subjects.Elevated NF-κB activation is conserved in human myocytes cultured from obese type 2 diabetic patients and attenuated by AMP-activated protein kinase Mitochondrial dysfunction and insulin resistance from the outside in: extracellular matrix, the cytoskeleton, and mitochondria.Defects in mitochondrial efficiency and H2O2 emissions in obese women are restored to a lean phenotype with aerobic exercise training.Salidroside ameliorates insulin resistance through activation of a mitochondria-associated AMPK/PI3K/Akt/GSK3β pathway.Pathobiochemical changes in diabetic skeletal muscle as revealed by mass-spectrometry-based proteomics Antioxidant treatment normalizes mitochondrial energetics and myocardial insulin sensitivity independently of changes in systemic metabolic homeostasis in a mouse model of the metabolic syndrome.Mitochondrial dysfunction in insulin resistance: differential contributions of chronic insulin and saturated fatty acid exposure in muscle cells Intrinsic aerobic capacity correlates with greater inherent mitochondrial oxidative and H2O2 emission capacities without major shifts in myosin heavy chain isoform Differential Mitochondrial Adaptation in Primary Vascular Smooth Muscle Cells from a Diabetic Rat Model.Obesity-induced tissue free radical generation: an in vivo immuno-spin trapping study.ANT1-mediated fatty acid-induced uncoupling as a target for improving myocellular insulin sensitivity.The mitochondrial function of the cerebral vasculature in insulin-resistant Zucker obese rats Proteomics analyses of subcutaneous adipocytes reveal novel abnormalities in human insulin resistance.The positive association of branched-chain amino acids and metabolic dyslipidemia in Chinese Han population.Mitochondrial lipid oxidation is impaired in cultured myotubes from obese humans.Mitochondrial respiratory capacity and content are normal in young insulin-resistant obese humans.Sites of superoxide and hydrogen peroxide production during fatty acid oxidation in rat skeletal muscle mitochondria.Global IRS-1 phosphorylation analysis in insulin resistance.Resistance training to improve type 2 diabetes: working toward a prescription for the future.Mitochondrial pathophysiology and type 2 diabetes mellitus.The role of mitochondria in insulin resistance and type 2 diabetes mellitus.Mitochondrial reactive oxygen species and risk of atherosclerosis.Insulin resistance and the metabolism of branched-chain amino acids.

P2860

Q26744725-07A74D28-A8E3-4625-89B9-1CD1A88F0A58 Q26752592-4913CCEE-2743-4A83-BCAC-152035A1545F Q26772781-7BCC788C-FD52-417A-9D42-88FAAC9C5436 Q26865069-2A1A7BCF-551B-432E-A086-B90F51002EE7 Q28076120-7F0B8CF0-A00A-440E-A54E-4258E287D1D0 Q28249276-5A73542B-5C4A-4AB1-B96B-39BEA2286799 Q28728745-39280B98-106B-471A-A303-2319CCB1053B Q33599932-9F9C3F9A-0C6B-4B78-9DC8-5CA16189C543 Q33792753-F808B17F-0DDC-403A-8B29-44D0BE4DD3C1 Q33837997-DD359DE5-2BBE-4061-AF89-9E7258122E91 Q33931142-CF5E5F03-00DB-49E5-97C4-A3E2665887BE Q33968101-16F64AC2-C1BA-4577-AD2B-91FEDC2C1817 Q34147741-23B6C8B5-5097-48FC-ABEF-F49CAE79F479 Q34269093-55650446-864F-469D-8CBD-8EC1F9F302C7 Q34318248-CA44158B-434D-4A24-9773-54BE9B5B5560 Q34472544-5EA23618-20A2-4370-8D9D-53BD3127532D Q35188031-70F985B2-5885-463E-BEB1-07C21D82F8D0 Q35405108-B9A6430D-1349-4F22-BC0D-8E6E13CF0BF2 Q35543642-86FD4231-18A9-4024-9986-8644B849E9B2 Q35630850-C9A9D104-4CC9-4CF9-BDAC-AB052B8E9EBB Q35846190-A3FEE223-628F-474E-A8EC-20215CDF1945 Q35864829-D6C2A68C-017B-47FB-96FC-FFF48330D798 Q35931589-310298E8-23D1-4A86-B38C-58FC30D7AA45 Q36330418-D520680C-7352-429D-951B-DFB4E809B0A7 Q36473653-12938712-9EC7-41F3-BE4E-CEE487ACBC2B Q36532336-15F1F629-C040-4E27-A126-EC5FD04B6DB9 Q36697347-47B5CD0E-1A92-4136-BFCE-7CFC852A0C46 Q36783125-3030874D-3F01-4798-871D-14FF1E42244C Q36902436-A55A7D0C-568E-492C-9A56-FF6B78CC6ECD Q37051235-9805C9E6-53CC-4DED-80C7-5036EC326B50 Q37125652-32A600E7-2D14-410E-BF8E-D96F70848A37 Q37359316-DCFBCD3E-6AB6-4A15-AEB0-5A1A92F4FB1C Q37403358-57DEB532-82C6-4997-9210-B504032FED32 Q37412145-60BE6971-C587-4801-A235-A5B409A22429 Q37439028-295599BC-E7B2-4211-A268-8561BCC4753C Q37679183-5057D4CD-4D8A-455D-8D5C-BAEFEB830DE0 Q37889277-F70A07B3-E075-49B1-860D-A10631E4EFD1 Q37930956-4560278C-CD10-4FC5-B3F6-8F61CEB3890E Q37986582-870F324E-3CCD-405E-A4DE-36093ECFEA40 Q38079446-B03DC88E-105D-4E62-825C-DDEE707BC4B2

P2860

Increased reactive oxygen species production and lower abundance of complex I subunits and carnitine palmitoyltransferase 1B protein despite normal mitochondrial respiration in insulin-resistant human skeletal muscle

Item

http://www.wikidata.org/entity/Q35757202

description

2010 nî lūn-bûn

@nan

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

2010年论文

@zh

2010年论文

@zh-cn

name

Increased reactive oxygen spec ...... esistant human skeletal muscle

@ast

Increased reactive oxygen spec ...... esistant human skeletal muscle

@en

type

Item

label

Increased reactive oxygen spec ...... esistant human skeletal muscle

@ast

Increased reactive oxygen spec ...... esistant human skeletal muscle

@en

prefLabel

Increased reactive oxygen spec ...... esistant human skeletal muscle

@ast

Increased reactive oxygen spec ...... esistant human skeletal muscle

@en

P1476

Increased reactive oxygen spec ...... esistant human skeletal muscle

@en

P2093

Benjamin Bowen

http://www.w3.org/2001/XMLSchema#string

Brian Glancy

http://www.w3.org/2001/XMLSchema#string

Christian Meyer

http://www.w3.org/2001/XMLSchema#string

Colleen Brophy

http://www.w3.org/2001/XMLSchema#string

Elena A De Filippis

http://www.w3.org/2001/XMLSchema#string

Kurt Højlund

http://www.w3.org/2001/XMLSchema#string

Lawrence J Mandarino

http://www.w3.org/2001/XMLSchema#string

Natalie Lefort

http://www.w3.org/2001/XMLSchema#string

Wayne T Willis

http://www.w3.org/2001/XMLSchema#string

Zachary Bailowitz

http://www.w3.org/2001/XMLSchema#string

P2860

Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation

Antioxidants prevent health-promoting effects of physical exercise in humans

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents

Free radicals in the physiological control of cell function

A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance

High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes

Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes

P304

2444-2452

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.2337/DB10-0174

http://www.w3.org/2001/XMLSchema#string

P407

English

P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P50

Kurt Højlund

P577

2010-08-03T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

45494042

http://www.w3.org/2001/XMLSchema#string

P698

20682693

http://www.w3.org/2001/XMLSchema#string

P921

Insulin

P932

3279558

http://www.w3.org/2001/XMLSchema#string

Increased reactive oxygen species production and lower abundance of complex I subunits and carnitine palmitoyltransferase 1B protein despite normal mitochondrial respiration in insulin-resistant human skeletal muscle

about

P2860

P2860

Increased reactive oxygen species production and lower abundance of complex I subunits and carnitine palmitoyltransferase 1B protein despite normal mitochondrial respiration in insulin-resistant human skeletal muscle

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P5875

P698

P921

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P5875

P698

P921

P932