Effects of cellular, chemical, and pharmacological chaperones on the rescue of a trafficking-defective mutant of the ATP-binding cassette transporter proteins ABCB1/ABCB4.
about
Recent advances in understanding and managing cholestasisDefining the blanks--pharmacochaperoning of SLC6 transporters and ABC transportersPharmacological chaperoning: a primer on mechanism and pharmacologyFunctional Rescue of Trafficking-Impaired ABCB4 Mutants by Chemical ChaperonesPhenylalanine hydroxylase misfolding and pharmacological chaperones.A PDZ-Like Motif in the Biliary Transporter ABCB4 Interacts with the Scaffold Protein EBP50 and Regulates ABCB4 Cell Surface Expression.Functional defect of variants in the adenosine triphosphate-binding sites of ABCB4 and their rescue by the cystic fibrosis transmembrane conductance regulator potentiator, ivacaftor (VX-770).P-glycoprotein is fully active after multiple tryptophan substitutionsFunctional characterization of ABCB4 mutations found in progressive familial intrahepatic cholestasis type 3Inside job: ligand-receptor pharmacology beneath the plasma membrane.Mutations in intracellular loops 1 and 3 lead to misfolding of human P-glycoprotein (ABCB1) that can be rescued by cyclosporine A, which reduces its association with chaperone Hsp70.Functional Characterization of ABCB4 Mutations Found in Low Phospholipid-Associated Cholelithiasis (LPAC).Clinical utility gene card for: progressive familial intrahepatic cholestasis type 3Molecular mechanisms for biliary phospholipid and drug efflux mediated by ABCB4 and bile saltsCurrent and future therapies for inherited cholestatic liver diseases.Reversing ABCB1-mediated multi-drug resistance from within cells using translocating immune conjugates.Folding correction of ABC-transporter ABCB1 by pharmacological chaperones: a mechanistic concept.Human bile acid transporter ASBT (SLC10A2) forms functional non-covalent homodimers and higher order oligomers.A functional classification of ABCB4 variations causing progressive familial intrahepatic cholestasis type 3.Heterozygous ABCB4 mutations in children with cholestatic liver disease.Phosphorylation of ABCB4 impacts its function: insights from disease-causing mutations.
P2860
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P2860
Effects of cellular, chemical, and pharmacological chaperones on the rescue of a trafficking-defective mutant of the ATP-binding cassette transporter proteins ABCB1/ABCB4.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Effects of cellular, chemical, ...... nsporter proteins ABCB1/ABCB4.
@ast
Effects of cellular, chemical, ...... nsporter proteins ABCB1/ABCB4.
@en
type
label
Effects of cellular, chemical, ...... nsporter proteins ABCB1/ABCB4.
@ast
Effects of cellular, chemical, ...... nsporter proteins ABCB1/ABCB4.
@en
prefLabel
Effects of cellular, chemical, ...... nsporter proteins ABCB1/ABCB4.
@ast
Effects of cellular, chemical, ...... nsporter proteins ABCB1/ABCB4.
@en
P2093
P2860
P356
P1476
Effects of cellular, chemical, ...... nsporter proteins ABCB1/ABCB4.
@en
P2093
Alegna Rada
Anne-Marie Durand-Schneider
Chantal Housset
Danièle Delautier
Jean-Louis Delaunay
Julie Gabillet
Julien Gautherot
Michèle Maurice
Tounsia Aït-Slimane
P2860
P304
P356
10.1074/JBC.M111.275438
P407
P577
2011-12-19T00:00:00Z