Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) differentially regulates orthosteric but not allosteric agonist binding and function.
about
The class B G-protein-coupled GLP-1 receptor: an important target for the treatment of type-2 diabetes mellitusA Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal StructuresGlucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic SuccessesKey interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptorMolecular mechanisms of bitopic ligand engagement with the M1 muscarinic acetylcholine receptorGlucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery.Gut peptide GLP-1 and its analogue, Exendin-4, decrease alcohol intake and rewardPolar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations.Minireview: Signal bias, allosterism, and polymorphic variation at the GLP-1R: implications for drug discoveryStructural and functional insights into the juxtamembranous amino-terminal tail and extracellular loop regions of class B GPCRs.Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function.Approaches for probing allosteric interactions at 7 transmembrane spanning receptors.Paralog-divergent Features May Help Reduce Off-target Effects of Drugs: Hints from Glucagon Subfamily Analysis.The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach.β-Arrestin-Biased Agonists of the GLP-1 Receptor from β-Amino Acid Residue Incorporation into GLP-1 Analogues.
P2860
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P2860
Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) differentially regulates orthosteric but not allosteric agonist binding and function.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Second extracellular loop of h ...... agonist binding and function.
@ast
Second extracellular loop of h ...... agonist binding and function.
@en
type
label
Second extracellular loop of h ...... agonist binding and function.
@ast
Second extracellular loop of h ...... agonist binding and function.
@en
prefLabel
Second extracellular loop of h ...... agonist binding and function.
@ast
Second extracellular loop of h ...... agonist binding and function.
@en
P2093
P2860
P50
P356
P1476
Second extracellular loop of h ...... c agonist binding and function
@en
P2093
Cassandra Koole
Emilia E Savage
Laurence J Miller
P2860
P304
P356
10.1074/JBC.M111.309369
P407
P577
2011-12-06T00:00:00Z