Loss of PTEN is associated with elevated EGFR and HER2 expression and worse prognosis in salivary gland cancer - Wikidata - awgldk - TriplyDB

Loss of PTEN is associated with elevated EGFR and HER2 expression and worse prognosis in salivary gland cancer

Loss of PTEN is associated with elevated EGFR and HER2 expression and worse prognosis in salivary gland cancer

http://www.wikidata.org/entity/Q35764742

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The Justy mutant mouse strain produces a spontaneous murine model of salivary gland cancer with myoepithelial and basal cell differentiation Racial and Ethnic Disparities in Salivary Gland Cancer Survival High-throughput profiling identifies clinically actionable mutations in salivary duct carcinoma.Genomic aberrations of MDM2, MDM4, FGFR1 and FGFR3 are associated with poor outcome in patients with salivary gland cancer.PTEN and Ki67 expression is associated with clinicopathologic features of non-small cell lung cancer.Somatic copy number alterations associated with Japanese or endometriosis in ovarian clear cell adenocarcinoma PIK3CA, HRAS and PTEN in human papillomavirus positive oropharyngeal squamous cell carcinoma.Human Epidermal Growth Factor Receptor 2 (HER2/neu) in Salivary Gland Carcinomas: A Review of Literature.High frequency of loss of PTEN expression in human solid salivary adenoid cystic carcinoma and its implication for targeted therapy.Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST.Salivary gland carcinomas.Immunohistochemical analysis of salivary gland tumors: application for surgical pathology practice.Genetic alterations in salivary gland cancers.Functional inactivation of Rb sensitizes cancer cells to TSC2 inactivation induced cell death Aberrations of MET are associated with copy number gain of EGFR and loss of PTEN and predict poor outcome in patients with salivary gland cancer.Expression, Mutation, and Amplification Status of EGFR and Its Correlation with Five miRNAs in Salivary Gland Tumours.Predictors of cervical lymph node metastasis in salivary gland cancer.The prognostic impact of human leukocyte antigen (HLA) class I antigen abnormalities in salivary gland cancer. A clinicopathological study of 288 cases.Somatic mutations in salivary duct carcinoma and potential therapeutic targets.Single nucleotide polymorphisms rs701848 and rs2735343 in PTEN increases cancer risks in an Asian population.Expression and mutational status of treatment-relevant targets and key oncogenes in 123 malignant salivary gland tumours.Lacrimal gland ductal carcinomas: Clinical, Morphological and Genetic characterization and implications for targeted treatment.Expression and clinical evidence of miR-494 and PTEN in non-small cell lung cancer.Cooperation Between Pten and Smad4 in Murine Salivary Gland Tumor Formation and Progression.

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P2860

Loss of PTEN is associated with elevated EGFR and HER2 expression and worse prognosis in salivary gland cancer

http://www.wikidata.org/entity/Q35764742

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British Journal of Cancer

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P2860

The PI3K pathway as drug target in human cancer

PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

PTEN activity could be a predictive marker of trastuzumab efficacy in the treatment of ErbB2-overexpressing breast cancer

Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas.

FISH analysis of 107 prostate cancers shows that PTEN genomic deletion is associated with poor clinical outcome.

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up

Pten is essential for embryonic development and tumour suppression

EGFR antagonists in cancer treatment

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719-726

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10.1038/BJC.2011.605

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4

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106

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