The preclinical pharmacology of the high affinity anti-IL-6R Nanobody® ALX-0061 supports its clinical development in rheumatoid arthritis.
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Nanobody-derived nanobiotechnology tool kits for diverse biomedical and biotechnology applicationsAnimal Models of Bone Loss in Inflammatory Arthritis: from Cytokines in the Bench to Novel Treatments for Bone Loss in the Bedside-a Comprehensive ReviewElucidation of the molecular mechanisms of two nanobodies that inhibit thrombin-activatable fibrinolysis inhibitor activation and activated thrombin-activatable fibrinolysis inhibitor activityGeneration of a highly diverse panel of antagonistic chicken monoclonal antibodies against the GIP receptorSingle domain antibodies for the knockdown of cytosolic and nuclear proteins.Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state.Antibody and antibody mimetic immunotherapeutics.Old and new therapeutics for Rheumatoid Arthritis: in vivo models and drug development.Profile of sarilumab and its potential in the treatment of rheumatoid arthritis.Half-life extended biotherapeutics.Extending the half-life of a fab fragment through generation of a humanized anti-human serum albumin Fv domain: An investigation into the correlation between affinity and serum half-life.The making of bispecific antibodiesInstitute collection and analysis of Nanobodies (iCAN): a comprehensive database and analysis platform for nanobodies.Half-life extension using serum albumin-binding DARPin® domains.Nanobody-Based Delivery Systems for Diagnosis and Targeted Tumor Therapy.Anti-carbamylated protein antibodies precede disease onset in monkeys with collagen-induced arthritis.Structural basis of nanobody-mediated blocking of BtuF, the cognate substrate-binding protein of the Escherichia coli vitamin B12 transporter BtuCD.Development of a novel nano-sized anti-VEGFA nanobody with enhanced physicochemical and pharmacokinetic properties.Yeast surface display platform for rapid discovery of conformationally selective nanobodies.Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation.
P2860
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P2860
The preclinical pharmacology of the high affinity anti-IL-6R Nanobody® ALX-0061 supports its clinical development in rheumatoid arthritis.
description
2015 nî lūn-bûn
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2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
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name
The preclinical pharmacology o ...... pment in rheumatoid arthritis.
@ast
The preclinical pharmacology o ...... pment in rheumatoid arthritis.
@en
type
label
The preclinical pharmacology o ...... pment in rheumatoid arthritis.
@ast
The preclinical pharmacology o ...... pment in rheumatoid arthritis.
@en
prefLabel
The preclinical pharmacology o ...... pment in rheumatoid arthritis.
@ast
The preclinical pharmacology o ...... pment in rheumatoid arthritis.
@en
P2093
P2860
P1476
The preclinical pharmacology o ...... pment in rheumatoid arthritis.
@en
P2093
Alex Hemeryck
Bert 't Hart
Cedric Ververken
Elia Breedveld
Els Beirnaert
Hans Ulrichts
Joost Kolkman
Judith Baumeister
Lieselot Bontinck
Maarten Van Roy
P2860
P2888
P356
10.1186/S13075-015-0651-0
P577
2015-05-20T00:00:00Z
P5875
P6179
1051886960