Exclusion of T Cells From Pancreatic Carcinomas in Mice Is Regulated by Ly6C(low) F4/80(+) Extratumoral Macrophages
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Chemotherapy and tumor microenvironment of pancreatic cancer.CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma.Making Better Chimeric Antigen Receptors for Adoptive T-cell TherapyIFNγ and CCL2 Cooperate to Redirect Tumor-Infiltrating Monocytes to Degrade Fibrosis and Enhance Chemotherapy Efficacy in Pancreatic CarcinomaSystemic Immune Activity Predicts Overall Survival in Treatment-Naïve Patients with Metastatic Pancreatic Cancer.Genetically Engineered Mouse Models of Pancreatic Cancer: The KPC Model (LSL-Kras(G12D/+) ;LSL-Trp53(R172H/+) ;Pdx-1-Cre), Its Variants, and Their Application in Immuno-oncology Drug Discovery.CD40 Stimulation Obviates Innate Sensors and Drives T Cell Immunity in Cancer.Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy.Transformation of the tumour microenvironment by a CD40 agonist antibody correlates with improved responses to PD-L1 blockade in a mouse orthotopic pancreatic tumour model.Downstream mediators of the intratumoral interferon response suppress antitumor immunity, induce gemcitabine resistance and associate with poor survival in human pancreatic cancer.Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancerMacrophages as Key Drivers of Cancer Progression and Metastasis.Stromal cues regulate the pancreatic cancer epigenome and metabolome.Prognostic role and correlation of CA9, CD31, CD68 and CD20 with the desmoplastic stroma in pancreatic ductal adenocarcinoma.CTLA-4/CD80 pathway regulates T cell infiltration into pancreatic cancer.Macrophages and pancreatic ductal adenocarcinoma.CSF-1R-Dependent Lethal Hepatotoxicity When Agonistic CD40 Antibody Is Given before but Not after Chemotherapy.Cancer immunotherapy: activating innate and adaptive immunity through CD40 agonists.Chimeric antigen receptor-modified T cells for the treatment of solid tumors: Defining the challenges and next steps.Inflammation as a driver and vulnerability of KRAS mediated oncogenesisThe role of myeloid cells in cancer therapies.Macrophage PI3Kγ Drives Pancreatic Ductal Adenocarcinoma Progression.Pancreatic cancer microenvironment, to target or not to target?Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer.PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy.CXCR2-Dependent Accumulation of Tumor-Associated Neutrophils Regulates T-cell Immunity in Pancreatic Ductal Adenocarcinoma.Intra-tumoral production of IL18, but not IL12, by TCR-engineered T cells is non-toxic and counteracts immune evasion of solid tumors.T-cell Localization, Activation, and Clonal Expansion in Human Pancreatic Ductal Adenocarcinoma.Combined sublethal irradiation and agonist anti-CD40 enhance donor T cell accumulation and control of autochthonous murine pancreatic tumors.Clinical evaluation of macrophages in cancer: role in treatment, modulation and challenges.An overview of polyamine metabolism in pancreatic ductal adenocarcinoma.Macrophages: Key orchestrators of a tumor microenvironment defined by therapeutic resistance.Targeting cytokine therapy to the pancreatic tumor microenvironment using PD-L1 specific VHHs.Preclinical mouse solid tumour models: status quo, challenges and perspectives.Activity of Mesothelin-specific Chimeric Antigen Receptor T cells Against Pancreatic Carcinoma Metastases in a Phase 1 Trial.Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression.Understanding the tumor immune microenvironment (TIME) for effective therapy.Tumor-Derived CCL2 Mediates Resistance to Radiotherapy in Pancreatic Ductal Adenocarcinoma.Strategies for Increasing Pancreatic Tumor Immunogenicity.Immunotherapy in pancreatic adenocarcinoma-overcoming barriers to response.
P2860
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P2860
Exclusion of T Cells From Pancreatic Carcinomas in Mice Is Regulated by Ly6C(low) F4/80(+) Extratumoral Macrophages
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Exclusion of T Cells From Panc ...... 80(+) Extratumoral Macrophages
@ast
Exclusion of T Cells From Panc ...... 80(+) Extratumoral Macrophages
@en
type
label
Exclusion of T Cells From Panc ...... 80(+) Extratumoral Macrophages
@ast
Exclusion of T Cells From Panc ...... 80(+) Extratumoral Macrophages
@en
prefLabel
Exclusion of T Cells From Panc ...... 80(+) Extratumoral Macrophages
@ast
Exclusion of T Cells From Panc ...... 80(+) Extratumoral Macrophages
@en
P2093
P2860
P50
P1433
P1476
Exclusion of T Cells From Panc ...... 80(+) Extratumoral Macrophages
@en
P2093
Cynthia Clendenin
Dawson M Knoblock
Kristen B Long
Patrick D Guirnalda
Rafael Winograd
Rebecca A Evans
Robert H Vonderheide
Whitney L Gladney
P2860
P304
P356
10.1053/J.GASTRO.2015.04.010
P407
P577
2015-04-14T00:00:00Z