Deficiency of H3K79 histone methyltransferase Dot1-like protein (DOT1L) inhibits cell proliferation
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Targeting the epigenome in lung cancer: expanding approaches to epigenetic therapyTargeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectivesThe many faces of histone H3K79 methylationEpigenetic regulators as promising therapeutic targets in acute myeloid leukemiaEpigenetics and the control of the collecting duct epithelial sodium channelEpigenome-based personalized medicine in human cancer2D-DIGE proteomic analysis of vastus lateralis from COPD patients with low and normal fat free mass index and healthy controlsA medicinal chemistry perspective for targeting histone H3 lysine-79 methyltransferase DOT1L.Histone methylation and aging: lessons learned from model systems.Inhibition of histone H3K79 methylation selectively inhibits proliferation, self-renewal and metastatic potential of breast cancerStatus of epigenetic chromatin modification enzymes and esophageal squamous cell carcinoma risk in northeast Indian population.DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progressionThe histone methyltransferase DOT1L: regulatory functions and a cancer therapy target.Dot1 histone methyltransferases share a distributive mechanism but have highly diverged catalytic properties.Role of several histone lysine methyltransferases in tumor development.Up-regulation of Histone Methyltransferase, DOT1L, by Matrix Hyaluronan Promotes MicroRNA-10 Expression Leading to Tumor Cell Invasion and Chemoresistance in Cancer Stem Cells from Head and Neck Squamous Cell Carcinoma.H4K20 methylation regulates quiescence and chromatin compaction.Epigenetics, drugs of abuse, and the retroviral promoter.Prognostic and therapeutic value of disruptor of telomeric silencing-1-like (DOT1L) expression in patients with ovarian cancer.Dynamics of DOT1L localization and H3K79 methylation during meiotic prophase I in mouse spermatocytes.Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia.The histone methyltransferase Dot1/DOT1L as a critical regulator of the cell cycle.The Aurora kinase A inhibitor TC-A2317 disrupts mitotic progression and inhibits cancer cell proliferation.Dot1l expression predicts adverse postoperative prognosis of patients with clear-cell renal cell carcinoma.Epigenetics in NG2 glia cells.The upstreams and downstreams of H3K79 methylation by DOT1L.Mitotic accumulation of dimethylated lysine 79 of histone H3 is important for maintaining genome integrity during mitosis in human cells.Writing, erasing and reading histone lysine methylations.Transcriptome analysis in calorie-restricted rats implicates epigenetic and post-translational mechanisms in neuroprotection and aging.DOT1L Activity Promotes Proliferation and Protects Cortical Neural Stem Cells from Activation of ATF4-DDIT3-Mediated ER Stress In Vitro.Activation of Matrix Hyaluronan-Mediated CD44 Signaling, Epigenetic Regulation and Chemoresistance in Head and Neck Cancer Stem Cells.Mllt10 knockout mouse model reveals critical role of Af10-dependent H3K79 methylation in midfacial developmentCCAR2 negatively regulates IL-8 production in cervical cancer cells.Integrative analysis reveals functional and regulatory roles of H3K79me2 in mediating alternative splicing.Transcriptional activator DOT1L putatively regulates human embryonic stem cell differentiation into the cardiac lineage.
P2860
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P2860
Deficiency of H3K79 histone methyltransferase Dot1-like protein (DOT1L) inhibits cell proliferation
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Deficiency of H3K79 histone me ...... L) inhibits cell proliferation
@ast
Deficiency of H3K79 histone me ...... L) inhibits cell proliferation
@en
type
label
Deficiency of H3K79 histone me ...... L) inhibits cell proliferation
@ast
Deficiency of H3K79 histone me ...... L) inhibits cell proliferation
@en
prefLabel
Deficiency of H3K79 histone me ...... L) inhibits cell proliferation
@ast
Deficiency of H3K79 histone me ...... L) inhibits cell proliferation
@en
P2093
P2860
P356
P1476
Deficiency of H3K79 histone me ...... L) inhibits cell proliferation
@en
P2093
Geunyeong Park
Ja-Eun Kim
Jong-Wan Park
Wootae Kim
P2860
P304
P356
10.1074/JBC.M111.328138
P407
P577
2011-12-21T00:00:00Z