Skeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction
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New insights into PGC-1 coactivators: redefining their role in the regulation of mitochondrial function and beyondIntegrative analysis of independent transcriptome data for rare diseasesPGC-1α and fasting-induced PDH regulation in mouse skeletal muscleG×G×E for lifespan in Drosophila: mitochondrial, nuclear, and dietary interactions that modify longevity.Integrated transcriptome analysis across mitochondrial disease etiologies and tissues improves understanding of common cellular adaptations to respiratory chain dysfunction.Increased mitochondrial biogenesis preserves intestinal stem cell homeostasis and contributes to longevity in Indy mutant flies.Impact of Aging and Exercise on Mitochondrial Quality Control in Skeletal Muscle.Mitochondria and ageing: role in heart, skeletal muscle and adipose tissue.Bone marrow adipose tissue is an endocrine organ that contributes to increased circulating adiponectin during caloric restriction.Genetically enhancing mitochondrial antioxidant activity improves muscle function in aging.Beta-lapachone, a modulator of NAD metabolism, prevents health declines in aged mice.Compensatory responses of the insulin signaling pathway restore muscle glucose uptake following long-term denervationResveratrol and SRT1720 Elicit Differential Effects in Metabolic Organs and Modulate Systemic Parameters Independently of Skeletal Muscle Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α)Fully automated software for quantitative measurements of mitochondrial morphology.Mitochondria and organismal longevity.Transcriptional Regulation by Nuclear Corepressors and PGC-1α: Implications for Mitochondrial Quality Control and Insulin Sensitivity.MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors.Nine months of combined training improves ex vivo skeletal muscle metabolism in individuals with type 2 diabetes.Metabolic switching and fuel choice during T-cell differentiation and memory development.Decreased levels of proapoptotic factors and increased key regulators of mitochondrial biogenesis constitute new potential beneficial features of long-lived growth hormone receptor gene-disrupted mice.Cell metabolomics.Genetic models of PGC-1 and glucose metabolism and homeostasisGlycolytic fast-twitch muscle fiber restoration counters adverse age-related changes in body composition and metabolism.Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation.The many roles of PGC-1α in muscle--recent developmentsMetabolomics approaches and applications in prostate cancer research.The metabolic regulation of aging.Connecting mitochondrial dynamics and life-or-death events via Bcl-2 family proteins.Caloric Restriction and the Nutrient-Sensing PGC-1α in Mitochondrial Homeostasis: New Perspectives in Neurodegeneration.Dietary intake of green tea polyphenols regulates insulin sensitivity with an increase in AMP-activated protein kinase α content and changes in mitochondrial respiratory complexes.Reduced skeletal muscle fiber size following caloric restriction is associated with calpain-mediated proteolysis and attenuation of IGF-1 signaling.Studies on meat color, myoglobin content, enzyme activities, and genes associated with oxidative potential of pigs slaughtered at different growth stages.The PDE4 inhibitor roflumilast reduces weight gain by increasing energy expenditure and leads to improved glucose metabolism.Ketone body 3-hydroxybutyrate mimics calorie restriction via the Nrf2 activator, fumarate, in the retina.Effects of Calorie Restriction and Fiber Type on Glucose Uptake and Abundance of Electron Transport Chain and Oxidative Phosphorylation Proteins in Single Fibers from Old Rats.A need for NAD+ in muscle development, homeostasis, and aging.Combined effects of resistance training and calorie restriction on mitochondrial fusion and fission proteins in rat skeletal muscle.Insulin Signaling and Glucose Uptake in the Soleus Muscle of 30-Month-Old Rats After Calorie Restriction With or Without Acute Exercise.Evidence that S6K1, but not 4E-BP1, mediates skeletal muscle pathology associated with loss of A-type lamins.
P2860
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P2860
Skeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Skeletal muscle transcriptiona ...... ges during calorie restriction
@ast
Skeletal muscle transcriptiona ...... ges during calorie restriction
@en
type
label
Skeletal muscle transcriptiona ...... ges during calorie restriction
@ast
Skeletal muscle transcriptiona ...... ges during calorie restriction
@en
prefLabel
Skeletal muscle transcriptiona ...... ges during calorie restriction
@ast
Skeletal muscle transcriptiona ...... ges during calorie restriction
@en
P2093
P2860
P50
P356
P1476
Skeletal muscle transcriptiona ...... ges during calorie restriction
@en
P2093
Amanda Souza
Kevin Bullock
Lydia W S Finley
Marcia C Haigis
Zoltan Arany
P2860
P304
P356
10.1073/PNAS.1115813109
P407
P577
2012-02-03T00:00:00Z