The Runx genes: lineage-specific oncogenes and tumor suppressors.
about
Repression of Runx2 by androgen receptor (AR) in osteoblasts and prostate cancer cells: AR binds Runx2 and abrogates its recruitment to DNARunx-dependent expression of PKC is critical for cell survival in the sea urchin embryoFactors and networks that underpin early hematopoiesisPar6G suppresses cell proliferation and is targeted by loss-of-function mutations in multiple cancers.Runx2 controls a feed-forward loop between androgen and prolactin-induced protein (PIP) in stimulating T47D cell proliferationRUNX3 has an oncogenic role in head and neck cancerRunt-related transcription factor 1 regulates luteinized hormone-induced prostaglandin-endoperoxide synthase 2 expression in rat periovulatory granulosa cellsDiscretization provides a conceptually simple tool to build expression networksSignificance of oncogenes and tumor suppressor genes in AML prognosis.Osteosarcomagenesis: modeling cancer initiation in the mouse.Developmentally regulated promoter-switch transcriptionally controls Runx1 function during embryonic hematopoiesisLoss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survivalNovel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression.Runx expression is mitogenic and mutually linked to Wnt activity in blastula-stage sea urchin embryosAML1/ETO oncoprotein is directed to AML1 binding regions and co-localizes with AML1 and HEB on its targets.Recurrent CDC25C mutations drive malignant transformation in FPD/AML.RUNX2 correlates with subtype-specific breast cancer in a human tissue microarray, and ectopic expression of Runx2 perturbs differentiation in the mouse mammary gland.A novel HMM-based method for detecting enriched transcription factor binding sites reveals RUNX3 as a potential target in pancreatic cancer biology.Research findings working with the p53 and Rb1 targeted osteosarcoma mouse model.Lung cancer stem cell: new insights on experimental models and preclinical data.Associations between genetic variants in the TGF-β signaling pathway and breast cancer risk among Hispanic and non-Hispanic white women.Periovulatory expression of hyaluronan and proteoglycan link protein 1 (Hapln1) in the rat ovary: hormonal regulation and potential function.The bone-specific expression of Runx2 oscillates during the cell cycle to support a G1-related antiproliferative function in osteoblasts.Sequence analysis of mutations and translocations across breast cancer subtypesMitotic bookmarking of genes: a novel dimension to epigenetic control.Groucho/transducin-like Enhancer-of-split (TLE)-dependent and -independent transcriptional regulation by Runx3.Genetic abnormalities and challenges in the treatment of acute myeloid leukemia.Functionally deregulated AML1/RUNX1 cooperates with BCR-ABL to induce a blastic phase-like phenotype of chronic myelogenous leukemia in mice.A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth.RUNX transcription factors: association with pediatric asthma and modulated by maternal smoking.Mitotic retention of gene expression patterns by the cell fate-determining transcription factor Runx2.Runx1 is associated with breast cancer progression in MMTV-PyMT transgenic mice and its depletion in vitro inhibits migration and invasionRUNX3 is oncogenic in natural killer/T-cell lymphoma and is transcriptionally regulated by MYC.ERG and FLI1 binding sites demarcate targets for aberrant epigenetic regulation by AML1-ETO in acute myeloid leukemiaSuppression of interneuron programs and maintenance of selected spinal motor neuron fates by the transcription factor AML1/Runx1.The cancer-related transcription factor Runx2 modulates cell proliferation in human osteosarcoma cell linesChaperonin TRiC/CCT Modulates the Folding and Activity of Leukemogenic Fusion Oncoprotein AML1-ETO.RUNX1a enhances hematopoietic lineage commitment from human embryonic stem cells and inducible pluripotent stem cellsSea urchin akt activity is Runx-dependent and required for post-cleavage stage cell division.Analysis of RUNX1 binding site and RAPTOR polymorphisms in psoriasis: no evidence for association despite adequate power and evidence for linkage
P2860
Q24641909-C1E9D5CF-DD23-4387-81BB-4FA65E57BA39Q24813683-AB355ABB-209D-4E18-93B1-747F3B89655FQ27022335-D8CC30D8-DBCE-4876-8DDB-5DF537D2A55DQ27309997-D1205AF5-11DE-4D32-8E17-6F34C21DF1A2Q28244711-CD4FFE62-FA90-4B54-8DC9-9D1CF2B26BFEQ28475605-9C5D4BFC-2863-48CB-8A02-46494465C5F2Q28581464-6C5C00A8-E211-45EF-9ED6-68AC0AB042A9Q28740944-4EBFBDCD-69E7-437D-9C96-8644B77282E5Q30250315-1BB4BD0C-FEFB-43F2-AEA7-3C460241E4D3Q30476415-6081D836-AE0F-4AA9-B425-0EF237903EC9Q33290634-76A3BECF-5E9F-4237-B5EB-A549DAF5FBB3Q33318747-C18F5104-0A87-4F01-B816-18C5951517A8Q33343446-BB3D7A8A-FECD-4144-9450-2A57A2548C1DQ33385660-D3B32625-D3D9-4A47-AFCD-54EFF288FD7BQ33388188-6DF1FAC0-653B-4326-864C-8444E0EA5410Q33417335-F6776F54-CF64-4DFF-BA8F-C84A62318334Q33555996-80EB685D-2D02-49E9-8E3C-21F6D5770CEDQ33784821-C7163879-9719-4DD2-AED6-4EBC1A7A73B4Q33785597-7C4B6ED0-8106-4B8B-B4B5-78B73BAB1737Q33786637-5A71085D-37AE-4302-9A6A-F60D18A66A3AQ33869600-D6068A27-4C16-4CEF-BC6F-9DB8AD21455EQ33874344-20F69D0C-AF7B-425F-84E3-0FFB7C1B54EBQ33953806-A3143C07-D2AB-4B2B-9C30-3158D373DDB1Q34032470-EDA38FF9-F6B8-4796-BF6C-3D3C17A613CCQ34551588-F63B59A9-5658-44FF-9FFA-B33632884919Q34624534-7835A2CC-D28F-454D-8FE0-DD40D338F554Q34631111-CC4276FE-4471-4550-BEE6-B7EA6D35C4E8Q35009923-81480132-8E47-4589-A094-81AB4F5EEFB7Q35173269-3F6DA41F-7769-461A-BAE6-3F6774DB8D87Q35543588-5239BB1B-4B5C-46CB-AB0A-C528FD287922Q35652284-484E61AE-250B-4391-AA6D-69524423A8FEQ35782827-C7ED5C95-AC1C-4C9B-BE0D-A757CE370BF9Q36259257-1CE9B15A-F107-464F-90F0-A5A016E18F43Q36395611-2B7004F9-6245-49E3-8527-1CFE33A1A562Q36609114-1AE451C2-FA05-46D7-A83D-9315BD1C5A6FQ36672392-CB437E99-5307-4190-9E44-0F93EFE774D1Q36744579-479F9512-16AB-454D-BE58-5E11F4CBF65AQ36761531-C56DFC6D-318A-4E07-96BE-B6D21880153EQ36844774-B1537F74-66B5-4936-976D-DB6E8F9DABEFQ36929999-AC44EC54-6318-4AC7-952A-95D9E9C8DFBE
P2860
The Runx genes: lineage-specific oncogenes and tumor suppressors.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
The Runx genes: lineage-specific oncogenes and tumor suppressors.
@ast
The Runx genes: lineage-specific oncogenes and tumor suppressors.
@en
type
label
The Runx genes: lineage-specific oncogenes and tumor suppressors.
@ast
The Runx genes: lineage-specific oncogenes and tumor suppressors.
@en
prefLabel
The Runx genes: lineage-specific oncogenes and tumor suppressors.
@ast
The Runx genes: lineage-specific oncogenes and tumor suppressors.
@en
P2860
P356
P1433
P1476
The Runx genes: lineage-specific oncogenes and tumor suppressors.
@en
P2093
Ewan R Cameron
James C Neil
P2860
P2888
P304
P356
10.1038/SJ.ONC.1207130
P407
P577
2004-05-01T00:00:00Z