Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.
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Mithramycin forms a stable dimeric complex by chelating with Fe(II): DNA-interacting characteristics, cellular permeation and cytotoxicityCrystal Structure of Baeyer−Villiger Monooxygenase MtmOIV, the Key Enzyme of the Mithramycin Biosynthetic Pathway,The Crystal Structure and Mechanism of an Unusual Oxidoreductase, GilR, Involved in Gilvocarcin V BiosynthesisMolecular Insight into Substrate Recognition and Catalysis of Baeyer–Villiger Monooxygenase MtmOIV, the Key Frame-Modifying Enzyme in the Biosynthesis of Anticancer Agent MithramycinModulation of the activity of Sp transcription factors by mithramycin analogues as a new strategy for treatment of metastatic prostate cancerMithramycin exerts an anti-myeloma effect and displays anti-angiogenic effects through up-regulation of anti-angiogenic factorsGenome-wide modulation of gene transcription in ovarian carcinoma cells by a new mithramycin analogueEts1 is an effector of protein kinase Calpha in cancer cells.Metabolic engineering for the production of natural products.Crystal structure of the [Mg2+-(chromomycin A3)2]-d(TTGGCCAA)2 complex reveals GGCC binding specificity of the drug dimer chelated by a metal ionInhibition of Sp1-dependent transcription and antitumor activity of the new aureolic acid analogues mithramycin SDK and SK in human ovarian cancer xenografts.Quantitative determination of mithramycin in human plasma by a novel, sensitive ultra-HPLC-MS/MS method for clinical pharmacokinetic application.Novel GC-rich DNA-binding compound produced by a genetically engineered mutant of the mithramycin producer Streptomyces argillaceus exhibits improved transcriptional repressor activity: implications for cancer therapy.EPS8 inhibition increases cisplatin sensitivity in lung cancer cells.Nanoparticulate formulations of mithramycin analogs for enhanced cytotoxicity.Crystallization and X-ray diffraction properties of Baeyer-Villiger monooxygenase MtmOIV from the mithramycin biosynthetic pathway in Streptomyces argillaceus.A comprehensive review of glycosylated bacterial natural products.A novel mithramycin analogue with high antitumor activity and less toxicity generated by combinatorial biosynthesis.Antitumoral activity of the mithralog EC-8042 in triple negative breast cancer linked to cell cycle arrest in G2Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivitySemi-synthetic mithramycin SA derivatives with improved anticancer activity.Dimerization and DNA recognition rules of mithramycin and its analoguesPost-PKS tailoring steps of the spiramycin macrolactone ring in Streptomyces ambofaciensStudies on the synthesis of durhamycin A: stereoselective synthesis of a model aglycone.Structures of mithramycin analogues bound to DNA and implications for targeting transcription factor FLI1.Natural glycoconjugates with antitumor activity.Molecular insights on the biosynthesis of antitumour compounds by actinomycetes.Regioselective enzymatic acylation of complex natural products: expanding molecular diversity.Genetic regulation and manipulation for natural product discovery.Emerging role of SETDB1 as a therapeutic target.The chromomycin CmmA acetyltransferase: a membrane-bound enzyme as a tool for increasing structural diversity of the antitumour mithramycin.Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycinModification of the antibiotic olivomycin I at the 2'-keto group of the side chain. Novel derivatives, antitumor and topoisomerase I-poisoning activity.Mithramycin encapsulated in polymeric micelles by microfluidic technology as novel therapeutic protocol for beta-thalassemia.Premithramycinone G, an early shunt product of the mithramycin biosynthetic pathway accumulated upon inactivation of oxygenase MtmOIIChromomycin SA analogs from a marine-derived Streptomyces sp.A combined approach for β-thalassemia based on gene therapy-mediated adult hemoglobin (HbA) production and fetal hemoglobin (HbF) induction.Bioactive compounds from marine actinomycetes.Entropically-driven binding of mithramycin in the minor groove of C/G-rich DNA sequences.Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.
P2860
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P2860
Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Mithramycin SK, a novel antitu ...... gh combinatorial biosynthesis.
@ast
Mithramycin SK, a novel antitu ...... gh combinatorial biosynthesis.
@en
type
label
Mithramycin SK, a novel antitu ...... gh combinatorial biosynthesis.
@ast
Mithramycin SK, a novel antitu ...... gh combinatorial biosynthesis.
@en
prefLabel
Mithramycin SK, a novel antitu ...... gh combinatorial biosynthesis.
@ast
Mithramycin SK, a novel antitu ...... gh combinatorial biosynthesis.
@en
P2093
P2860
P356
P1476
Mithramycin SK, a novel antitu ...... gh combinatorial biosynthesis.
@en
P2093
Ana M González
José A Salas
Jürgen Rohr
Lily L Remsing
M José Fernández-Lozano
Marcos A Oliveira
Mohammad Nur-e-Alam
P2860
P304
P356
10.1021/JA034162H
P407
P577
2003-05-01T00:00:00Z