Use of a novel chimeric mouse model with a functionally active human immune system to study human immunodeficiency virus type 1 infection - Wikidata - awgldk - TriplyDB

Use of a novel chimeric mouse model with a functionally active human immune system to study human immunodeficiency virus type 1 infection

Use of a novel chimeric mouse model with a functionally active human immune system to study human immunodeficiency virus type 1 infection

http://www.wikidata.org/entity/Q35783479

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Priming of protective T cell responses against virus-induced tumors in mice with human immune system components Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them all New generation humanized mice for virus research: comparative aspects and future prospects A topical microbicide gel formulation of CCR5 antagonist maraviroc prevents HIV-1 vaginal transmission in humanized RAG-hu mice Evolution of the HIV-1 env gene in the Rag2-/- gammaC-/- humanized mouse model HIV-1 competition experiments in humanized mice show that APOBEC3H imposes selective pressure and promotes virus adaptation Oral pre-exposure prophylaxis by anti-retrovirals raltegravir and maraviroc protects against HIV-1 vaginal transmission in a humanized mouse model.Plasmacytoid dendritic cells in HIV infection: striking a delicate balance.Humanized Rag1-/- γc-/- mice support multilineage hematopoiesis and are susceptible to HIV-1 infection via systemic and vaginal routes HTLV-1 propels thymic human T cell development in "human immune system" Rag2⁻/⁻ gamma c⁻/⁻ mice.Highly active antiretroviral therapy potently suppresses HIV infection in humanized Rag2-/-gammac-/- mice APOBEC3D and APOBEC3F potently promote HIV-1 diversification and evolution in humanized mouse model.Links between progressive HIV-1 infection of humanized mice and viral neuropathogenesis CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice.Current humanized mouse models for studying human immunology and HIV-1 immuno-pathogenesis.Mice with human immune system components as in vivo models for infections with human pathogens.Mucosal transmission of R5 and X4 tropic HIV-1 via vaginal and rectal routes in humanized Rag2-/- gammac -/- (RAG-hu) mice.HIV-1 Vpr accelerates viral replication during acute infection by exploitation of proliferating CD4+ T cells in vivo The utility of the new generation of humanized mice to study HIV-1 infection: transmission, prevention, pathogenesis, and treatment.Hypogammaglobulinemia in BLT humanized mice--an animal model of primary antibody deficiency.Vpu augments the initial burst phase of HIV-1 propagation and downregulates BST2 and CD4 in humanized mice.Experimental evaluation of the zoonotic infection potency of simian retrovirus type 4 using humanized mouse model.Humanized Rag2(-/-)gammac(-/-) (RAG-hu) mice can sustain long-term chronic HIV-1 infection lasting more than a year.CD4+ cell-dependent granuloma formation in humanized mice infected with mycobacteria.Rapid evolution of HIV-1 to functional CD8⁺ T cell responses in humanized BLT mice.RAG2-/- gamma(c)-/- mice transplanted with CD34+ cells from human cord blood show low levels of intestinal engraftment and are resistant to rectal transmission of human immunodeficiency virus Murine models for HIV vaccination and challenge.Novel humanized murine models for HIV research.Humanized mouse models of HIV infection Can humanized mice reflect the complex pathobiology of HIV-associated neurocognitive disorders?The utilization of humanized mouse models for the study of human retroviral infections.Transgenic expression of the human LEDGF/p75 gene relieves the species barrier against HIV-1 infection in mouse cells RNA-interference-based gene therapy approaches to HIV type-1 treatment: tackling the hurdles from bench to bedside.HIV-1 immunopathogenesis in humanized mouse models.Possible applications for replicating HIV 1 vectors The mouse is out of the bag: insights and perspectives on HIV-1-infected humanized mouse models.Animal models in virus research: their utility and limitations.Human immune responses and potential for vaccine assessment in humanized mice.Infectious diseases in humanized mice.Humanized mouse as an appropriate model for accelerated global HIV research and vaccine development: current trend.

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P2860

Use of a novel chimeric mouse model with a functionally active human immune system to study human immunodeficiency virus type 1 infection

http://www.wikidata.org/entity/Q35783479

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Clinical and Vaccine Immunology

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Betty Poon

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Bianca Blom

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Christel H Uittenbogaart

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Dong Sung An

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Hergen Spits

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Irvin S Y Chen

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Kees Weijer

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Raphael Ho Tsong Fang

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P2860

Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice

Antiretroviral drug studies in nonhuman primates: a valid animal model for innovative drug efficacy and pathogenesis experiments.

Nonhuman primate models for AIDS.

Dead cell discrimination with 7-amino-actinomycin D in combination with dual color immunofluorescence in single laser flow cytometry.

Differential tropism and replication kinetics of human immunodeficiency virus type 1 isolates in thymocytes: coreceptor expression allows viral entry, but productive infection of distinct subsets is determined at the postentry level.

Formaldehyde-treated, heat-inactivated virions with increased human immunodeficiency virus type 1 env can be used to induce high-titer neutralizing antibody responses.

Impact of cytokines on replication in the thymus of primary human immunodeficiency virus type 1 isolates from infants.

Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2-/-gamma c-/- mice

Human immunodeficiency virus persistence and production in T-cell development

HIV-1 infection and pathogenesis in a novel humanized mouse model.

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10.1128/CVI.00403-06

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4

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1865603

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