mGluR6 deletion renders the TRPM1 channel in retina inactive. - Wikidata - awgldk - TriplyDB

mGluR6 deletion renders the TRPM1 channel in retina inactive.

mGluR6 deletion renders the TRPM1 channel in retina inactive.

http://www.wikidata.org/entity/Q35787600

about

Polymodal roles of transient receptor potential channels in the control of ocular function TRPV1 and Endocannabinoids: Emerging Molecular Signals that Modulate Mammalian Vision Neuronal remodeling in retinal circuit assembly, disassembly, and reassembly Restoring the ON Switch in Blind Retinas: Opto-mGluR6, a Next-Generation, Cell-Tailored Optogenetic Tool Lrit3 deficient mouse (nob6): a novel model of complete congenital stationary night blindness (cCSNB)Pregnenolone sulfate: from steroid metabolite to TRP channel ligand.Localization of Cacna1s to ON bipolar dendritic tips requires mGluR6-related cascade elements.Differential function of Gγ13 in rod bipolar and ON cone bipolar cells.Synaptic pathology and therapeutic repair in adult retinoschisis mouse by AAV-RS1 transfer.Gβ3 is required for normal light ON responses and synaptic maintenance LRIT3 is essential to localize TRPM1 to the dendritic tips of depolarizing bipolar cells and may play a role in cone synapse formation.The TRPM1 channel in ON-bipolar cells is gated by both the α and the βγ subunits of the G-protein Go Lack of mGluR6-related cascade elements leads to retrograde trans-synaptic effects on rod photoreceptor synapses via matrix-associated proteins.Ultrastructural localization of GPR179 and the impact of mutant forms on retinal function in CSNB1 patients and a mouse model.Cones respond to light in the absence of transducin β subunit.Present Molecular Limitations of ON-Bipolar Cell Targeted Gene Therapy.Mouse b-wave mutants.The Transduction Cascade in Retinal ON-Bipolar Cells: Signal Processing and Disease.ON-OFF Interactions in the Retina: Role of Glycine and GABA.Intravitreal delivery of a novel AAV vector targets ON bipolar cells and restores visual function in a mouse model of complete congenital stationary night blindness.Restoration of synaptic function in sight for degenerative retinal disease.Alterations in Kainate Receptor and TRPM1 Localization in Bipolar Cells after Retinal Photoreceptor Degeneration.Different Activity Patterns in Retinal Ganglion Cells of TRPM1 and mGluR6 Knockout Mice.

P2860

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P2860

mGluR6 deletion renders the TRPM1 channel in retina inactive.

http://www.wikidata.org/entity/Q35787600

description

2011 nî lūn-bûn

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2011年の論文

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2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

2011年论文

@zh

2011年论文

@zh-cn

name

mGluR6 deletion renders the TRPM1 channel in retina inactive.

@ast

mGluR6 deletion renders the TRPM1 channel in retina inactive.

@en

type

label

mGluR6 deletion renders the TRPM1 channel in retina inactive.

@ast

mGluR6 deletion renders the TRPM1 channel in retina inactive.

@en

prefLabel

mGluR6 deletion renders the TRPM1 channel in retina inactive.

@ast

mGluR6 deletion renders the TRPM1 channel in retina inactive.

@en

P1433

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P356

P1433

Journal of Neurophysiology

P1476

mGluR6 deletion renders the TRPM1 channel in retina inactive.

@en

P2093

Anuradha Dhingra

http://www.w3.org/2001/XMLSchema#string

Chieko Koike

http://www.w3.org/2001/XMLSchema#string

Marie E Fina

http://www.w3.org/2001/XMLSchema#string

Noga Vardi

http://www.w3.org/2001/XMLSchema#string

Takahisa Furukawa

http://www.w3.org/2001/XMLSchema#string

Ying Xu

http://www.w3.org/2001/XMLSchema#string

P2860

Recessive mutations of the gene TRPM1 abrogate ON bipolar cell function and cause complete congenital stationary night blindness in humans

Mutations in TRPM1 are a common cause of complete congenital stationary night blindness

G protein subunit G gamma 13 is coexpressed with G alpha o, G beta 3, and G beta 4 in retinal ON bipolar cells

Retinoschisin (RS1), the protein encoded by the X-linked retinoschisis gene, is anchored to the surface of retinal photoreceptor and bipolar cells through its interactions with a Na/K ATPase-SARM1 complex

Immunohistological studies of metabotropic glutamate receptor subtype 6-deficient mice show no abnormality of retinal cell organization and ganglion cell maturation

TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade

Impaired behavioral suppression by light in metabotropic glutamate receptor subtype 6-deficient mice

TRPM1 is required for the depolarizing light response in retinal ON-bipolar cells

Retinal ON bipolar cells express a new PCP2 splice variant that accelerates the light response

Targeting of RGS7/Gbeta5 to the dendritic tips of ON-bipolar cells is independent of its association with membrane anchor R7BP.

P304

948-957

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scholarly article

P356

10.1152/JN.00933.2011

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P407

P433

3

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P478

107

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2011-11-30T00:00:00Z

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P5875

51843899

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P698

22131384

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P932

3289472

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