Transgenic mice expressing a dominant-negative mutant type II transforming growth factor-beta receptor exhibit impaired mammary development and enhanced mammary tumor formation.
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Lack of transforming growth factor-β signaling promotes collective cancer cell invasion through tumor-stromal crosstalk.Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitroProteotypic classification of spontaneous and transgenic mammary neoplasmsAttenuated transforming growth factor beta signaling promotes metastasis in a model of HER2 mammary carcinogenesisStromal fibroblasts in cancer initiation and progressionOf extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer.Transforming growth factor-(beta)s and mammary gland involution; functional roles and implications for cancer progression.The miR-424(322)/503 cluster orchestrates remodeling of the epithelium in the involuting mammary gland.Two faces of TGF-beta1 in breast cancer.TGF-beta biology in mammary development and breast cancer.Transforming growth factor beta (TGF-beta) and inflammation in cancer.Wnt signaling can substitute for estrogen to induce division of ERalpha-positive cells in a mouse mammary tumor model.Cathepsin B is the driving force of esophageal cell invasion in a fibroblast-dependent manner.Integrin αvβ3 drives slug activation and stemness in the pregnant and neoplastic mammary gland.RAS/ERK modulates TGFbeta-regulated PTEN expression in human pancreatic adenocarcinoma cellsCoordinated functions of E-cadherin and transforming growth factor beta receptor II in vitro and in vivo.Concerted loss of TGFβ-mediated proliferation control and E-cadherin disrupts epithelial homeostasis and causes oral squamous cell carcinoma.Elevated CXCL1 expression in breast cancer stroma predicts poor prognosis and is inversely associated with expression of TGF-β signaling proteinsTGF-beta promotes cell death and suppresses lactation during the second stage of mammary involutionThe microRNA 424/503 cluster reduces CDC25A expression during cell cycle arrest imposed by transforming growth factor β in mammary epithelial cellsLoss of TGF-beta type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-alpha-, MSP- and HGF-mediated signaling networksTransforming growth factor-beta regulator SnoN modulates mammary gland branching morphogenesis, postlactational involution, and mammary tumorigenesisSnoN in mammalian development, function and diseases.Proteomics of TGF-beta signaling and its impact on breast cancer.Pro-metastasis function of TGFbeta mediated by the Smad pathway.The complexities of TGF-β action during mammary and squamous cell carcinogenesis.Mammary epithelial cell phagocytosis downstream of TGF-β3 is characterized by adherens junction reorganization.Transforming growth factor-beta in cancer and metastasis.Transforming growth factor-beta can suppress tumorigenesis through effects on the putative cancer stem or early progenitor cell and committed progeny in a breast cancer xenograft modelRole of TGF-β and the tumor microenvironment during mammary tumorigenesisThe TGFBeta pathway as a therapeutic target in cancer.Abrogation of TGF-beta signaling enhances chemokine production and correlates with prognosis in human breast cancer.Transforming growth factor-beta signaling: emerging stem cell target in metastatic breast cancer?Mammary involution and breast cancer risk: transgenic models and clinical studies.Signal transduction in transgenic mouse models of human breast cancer--implications for human breast cancer.A functional connection between pRB and transforming growth factor beta in growth inhibition and mammary gland developmentKey signalling nodes in mammary gland development and cancer. Mitogen-activated protein kinase signalling in experimental models of breast cancer progression and in mammary gland development.Dichloroacetate modulates cytokines toward T helper 1 function via induction of the interleukin-12-interferon-γ pathway.Role of TGF-β in breast cancer bone metastases.TGF-β: duality of function between tumor prevention and carcinogenesis.
P2860
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P2860
Transgenic mice expressing a dominant-negative mutant type II transforming growth factor-beta receptor exhibit impaired mammary development and enhanced mammary tumor formation.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Transgenic mice expressing a d ...... anced mammary tumor formation.
@ast
Transgenic mice expressing a d ...... anced mammary tumor formation.
@en
type
label
Transgenic mice expressing a d ...... anced mammary tumor formation.
@ast
Transgenic mice expressing a d ...... anced mammary tumor formation.
@en
prefLabel
Transgenic mice expressing a d ...... anced mammary tumor formation.
@ast
Transgenic mice expressing a d ...... anced mammary tumor formation.
@en
P2093
P2860
P1476
Transgenic mice expressing a d ...... anced mammary tumor formation.
@en
P2093
Agnieszka E Gorska
Mary E Aakre
Neil A Bhowmick
Roy A Jensen
P2860
P304
P356
10.1016/S0002-9440(10)63510-9
P407
P577
2003-10-01T00:00:00Z