Deficiency of NADPH oxidase components p47phox and gp91phox caused granulomatous synovitis and increased connective tissue destruction in experimental arthritis models.
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Oxidation in rheumatoid arthritis.Role of NADPH oxidase in formation and function of multinucleated giant cellsNADPH-oxidase-driven oxygen radical production determines chondrocyte death and partly regulates metalloproteinase-mediated cartilage matrix degradation during interferon-gamma-stimulated immune complex arthritisIdentification of a region in p47phox/NCF1 crucial for phagocytic NADPH oxidase (NOX2) activation.Burkholderia cenocepacia J2315 escapes to the cytosol and actively subverts autophagy in human macrophages.Harmful waste products as novel immune modulators for treating inflammatory arthritis?NADPH oxidase limits innate immune responses in the lungs in miceExperimental lupus is aggravated in mouse strains with impaired induction of neutrophil extracellular traps.Ncf1 (p47phox) is essential for direct regulatory T cell mediated suppression of CD4+ effector T cells.Anaplasma phagocytophilum infection induces protracted neutrophil degranulation.Point mutations in the proline-rich region of p22phox are dominant inhibitors of Nox1- and Nox2-dependent reactive oxygen generation.Reactive oxygen species deficiency induces autoimmunity with type 1 interferon signature.Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)Spontaneous and aging-dependent development of arthritis in NADPH oxidase 2 deficiency through altered differentiation of CD11b+ and Th/Treg cellsBb2Bb3 regulation of murine Lyme arthritis is distinct from Ncf1 and independent of the phagocyte nicotinamide adenine dinucleotide phosphate oxidaseOxidized phospholipid inhibition of toll-like receptor (TLR) signaling is restricted to TLR2 and TLR4: roles for CD14, LPS-binding protein, and MD2 as targets for specificity of inhibitionRegulation of innate immunity by NADPH oxidase.Techniques for assessing knee joint pain in arthritis.Impact of reactive oxygen species (ROS) on the control of parasite loads and inflammation in Leishmania amazonensis infectionNew tricks from an old dog: mitochondrial redox signaling in cellular inflammation.Decreased STAT5 phosphorylation and GATA-3 expression in NOX2-deficient T cells: role in T helper developmentNADPH oxidase controls phagosomal pH and antigen cross-presentation in human dendritic cells.Novel biphasic role for lymphocytes revealed during resolving inflammationHyperinflammation in chronic granulomatous disease and anti-inflammatory role of the phagocyte NADPH oxidase.Nonresolving inflammation in gp91phox-/- mice, a model of human chronic granulomatous disease, has lower adenosine and cyclic adenosine 5'-monophosphateEnhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene.Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans.Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation.Immunometabolism and autoimmunity.NADPH oxidase limits lipopolysaccharide-induced lung inflammation and injury in mice through reduction-oxidation regulation of NF-κB activity.Enhanced Th2 cell differentiation and function in the absence of Nox2.Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A2: activation of endogenous phospholipases contributes to the pronociceptive effectNADPH oxidase restrains the matrix metalloproteinase activity of macrophages.Null mutation of myeloperoxidase in mice prevents mechanical activation of neutrophil lysis of muscle cell membranes in vitro and in vivo.Branched fungal beta-glucan causes hyperinflammation and necrosis in phagocyte NADPH oxidase-deficient mice.Local activation of STAT-1 and STAT-3 in the inflamed synovium during zymosan-induced arthritis: exacerbation of joint inflammation in STAT-1 gene-knockout mice.Acid aspiration-induced lung inflammation and injury are exacerbated in NADPH oxidase-deficient mice.
P2860
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P2860
Deficiency of NADPH oxidase components p47phox and gp91phox caused granulomatous synovitis and increased connective tissue destruction in experimental arthritis models.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Deficiency of NADPH oxidase co ...... experimental arthritis models.
@ast
Deficiency of NADPH oxidase co ...... experimental arthritis models.
@en
type
label
Deficiency of NADPH oxidase co ...... experimental arthritis models.
@ast
Deficiency of NADPH oxidase co ...... experimental arthritis models.
@en
prefLabel
Deficiency of NADPH oxidase co ...... experimental arthritis models.
@ast
Deficiency of NADPH oxidase co ...... experimental arthritis models.
@en
P2093
P2860
P1476
Deficiency of NADPH oxidase co ...... experimental arthritis models.
@en
P2093
Brahm H Segal
Christina J J Coenen-de Roo
Erik Lubberts
Fons A J van de Loo
Leo A B Joosten
Miranda B Bennink
Onno J Arntz
Peter L E M van Lent
Ruben L Smeets
Steven M Holland
P2860
P304
P356
10.1016/S0002-9440(10)63509-2
P407
P577
2003-10-01T00:00:00Z