Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin.
about
Cloning and characterization of a family of proteins associated with MplThe molecular mechanisms that control thrombopoiesisFunctional analysis of Asb-1 using genetic modification in miceIdentification of mutations in the c-mpl gene in congenital amegakaryocytic thrombocytopeniaThe contribution of mouse models to the understanding of constitutional thrombocytopeniaStem cells, megakaryocytes, and plateletsPathophysiology and management of thrombocytopenia in bone marrow failure: possible clinical applications of TPO receptor agonists in aplastic anemia and myelodysplastic syndromesSTAT5 in hematopoietic stem cell biology and transplantationEltrombopag for the treatment of aplastic anemia: current perspectivesMutations in the thrombopoietin receptor, Mpl, in children with congenital amegakaryocytic thrombocytopeniaSlug deficiency enhances self-renewal of hematopoietic stem cells during hematopoietic regenerationLnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2MOZ is essential for maintenance of hematopoietic stem cellsA critical function for B-Raf at multiple stages of myelopoiesisQuantitative trait analysis reveals transforming growth factor-beta2 as a positive regulator of early hematopoietic progenitor and stem cell functionThrombopoietin acts synergistically with LIF to maintain an undifferentiated state of embryonic stem cells homozygous for a Shp-2 deletion mutationMERIT40 deficiency expands hematopoietic stem cell pools by regulating thrombopoietin receptor signalingHematopoietic stem cell: self-renewal versus differentiationBone marrow transplantation versus immunosuppressive therapy in patients with acquired severe aplastic anemia.Steel factor coordinately regulates the molecular signature and biologic function of hematopoietic stem cellsIncomplete restoration of Mpl expression in the mpl-/- mouse produces partial correction of the stem cell-repopulating defect and paradoxical thrombocytosis.Searching for stem cell regulatory molecules. Some general thoughts and possible approaches.Stem and progenitor cell subsets are affected by JAK2 signaling and can be monitored by flow cytometry.The role of Smad signaling in hematopoiesis.Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activityThrombopoietin.Comparative analyses of megakaryocytes derived from cord blood and bone marrow.Genetic deletion of murine SPRY domain-containing SOCS box protein 2 (SSB-2) results in very mild thrombocytopeniaHaematopoietic stem and progenitor cell-targeted therapies for thrombocytopenia.New insights and therapeutics for immune-mediated thrombocytopenia.Functional analysis of single amino-acid mutations in the thrombopoietin-receptor Mpl underlying congenital amegakaryocytic thrombocytopenia.Chimeric SCID-hu Model as a Human Hematopoietic Stem Cell Host That Recapitulates the Effects of HIV-1 on Bone Marrow Progenitors in Infected Patients.Gene therapy of MPL deficiency: challenging balance between leukemia and pancytopenia.New advances in the treatment of adult chronic immune thrombocytopenic purpura: role of thrombopoietin receptor-stimulating agents.Congenital amegakaryocytic thrombocytopenia: a brief review of the literatureThrombopoietin and hematopoietic stem cells.Inherited thrombocytopenias: an approach to diagnosis and management.Functional characterization of c-Mpl ectodomain mutations that underlie congenital amegakaryocytic thrombocytopenia.Inhibition of Thrombopoietin/Mpl Signaling in Adult Hematopoiesis Identifies New Candidates for Hematopoietic Stem Cell Maintenance.Thrombopoietin induces hematopoiesis from mouse ES cells via HIF-1α-dependent activation of a BMP4 autoregulatory loop.
P2860
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P2860
Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Hematopoietic stem cell defici ...... e receptor for thrombopoietin.
@ast
Hematopoietic stem cell defici ...... e receptor for thrombopoietin.
@en
type
label
Hematopoietic stem cell defici ...... e receptor for thrombopoietin.
@ast
Hematopoietic stem cell defici ...... e receptor for thrombopoietin.
@en
prefLabel
Hematopoietic stem cell defici ...... e receptor for thrombopoietin.
@ast
Hematopoietic stem cell defici ...... e receptor for thrombopoietin.
@en
P2093
P2860
P356
P1476
Hematopoietic stem cell defici ...... he receptor for thrombopoietin
@en
P2093
W S Alexander
P2860
P304
P356
10.1073/PNAS.95.3.1195
P407
P577
1998-02-01T00:00:00Z