Inhibition of the NFAT pathway alleviates amyloid β neurotoxicity in a mouse model of Alzheimer's disease.
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Abnormal synaptic Ca(2+) homeostasis and morphology in cortical neurons of familial hemiplegic migraine type 1 mutant miceThe Emerging Roles of the Calcineurin-Nuclear Factor of Activated T-Lymphocytes Pathway in Nervous System Functions and DiseasesMolecular mechanisms of cognitive dysfunction following traumatic brain injuryA central role for calcineurin in protein misfolding neurodegenerative diseases.The intersection of amyloid beta and tau at synapses in Alzheimer's diseaseCalcineurin and glial signaling: neuroinflammation and beyondNerve growth factor (NGF) regulates activity of nuclear factor of activated T-cells (NFAT) in neurons via the phosphatidylinositol 3-kinase (PI3K)-Akt-glycogen synthase kinase 3β (GSK3β) pathwayAttenuation of microglial activation in a mouse model of Alzheimer's disease via NFAT inhibitionReversal of Aging-Related Neuronal Ca2+ Dysregulation and Cognitive Impairment by Delivery of a Transgene Encoding FK506-Binding Protein 12.6/1b to the Hippocampus.Reduction of increased calcineurin activity rescues impaired homeostatic synaptic plasticity in presenilin 1 M146V mutant.Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease.Distinct activation properties of the nuclear factor of activated T-cells (NFAT) isoforms NFATc3 and NFATc4 in neurons.Genome-wide DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimer's disease.Capturing single L-type Ca(2+) channel function with opticsAstaxanthin Protects Primary Hippocampal Neurons against Noxious Effects of Aβ-Oligomers.MicroRNAs and intellectual disability (ID) in Down syndrome, X-linked ID, and Fragile X syndrome.Direct detection of alpha synuclein oligomers in vivoThe Role of Sirt1 in EpileptogenesisSoluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain.Involvement of 'stress-response' kinase pathways in Alzheimer's disease progression.Biometals and their therapeutic implications in Alzheimer's disease.Mechanisms and dynamics of AKAP79/150-orchestrated multi-protein signalling complexes in brain and peripheral nerve.Calcineurin/NFAT Signaling in Activated Astrocytes Drives Network Hyperexcitability in Aβ-Bearing Mice.Calcineurin proteolysis in astrocytes: Implications for impaired synaptic functionNegative feedback regulation of calcineurin-dependent Prz1 transcription factor by the CaMKK-CaMK1 axis in fission yeast.Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease.Activity-dependent transcriptional regulation of M-Type (Kv7) K(+) channels by AKAP79/150-mediated NFAT actions.NFATc2 Modulates Microglial Activation in the AβPP/PS1 Mouse Model of Alzheimer's Disease.Multifunctional Compound AD-35 Improves Cognitive Impairment and Attenuates the Production of TNF-α and IL-1β in an Aβ25-35-induced Rat Model of Alzheimer's Disease.Potential for therapeutic targeting of AKAP signaling complexes in nervous system disorders.Effects of molecular hydrogen assessed by an animal model and a randomized clinical study on mild cognitive impairment.Mutations modifying sporadic Alzheimer's disease age of onset.Deciphering the Astrocyte Reaction in Alzheimer's Disease.The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer's disease
P2860
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P2860
Inhibition of the NFAT pathway alleviates amyloid β neurotoxicity in a mouse model of Alzheimer's disease.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Inhibition of the NFAT pathway ...... model of Alzheimer's disease.
@ast
Inhibition of the NFAT pathway ...... model of Alzheimer's disease.
@en
type
label
Inhibition of the NFAT pathway ...... model of Alzheimer's disease.
@ast
Inhibition of the NFAT pathway ...... model of Alzheimer's disease.
@en
prefLabel
Inhibition of the NFAT pathway ...... model of Alzheimer's disease.
@ast
Inhibition of the NFAT pathway ...... model of Alzheimer's disease.
@en
P2093
P2860
P50
P1476
Inhibition of the NFAT pathway ...... model of Alzheimer's disease.
@en
P2093
Brian J Bacskai
Eloise Hudry
Hai-Yan Wu
Michal Arbel-Ornath
Rebecca A Betensky
Tadafumi Hashimoto
Zhanyun Fan
P2860
P304
P356
10.1523/JNEUROSCI.6439-11.2012
P407
P577
2012-02-01T00:00:00Z