Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk.
about
The genetic landscape of Alzheimer disease: clinical implications and perspectivesCurrent and future implications of basic and translational research on amyloid-β peptide production and removal pathwaysCombined effects of Alzheimer risk variants in the CLU and ApoE genes on ventricular expansion patterns in the elderly.Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.Intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein Tau in Alzheimer's diseaseGenome-wide association studies in Alzheimer's disease: a reviewIdentification of rare variants in Alzheimer's disease.Mutation analysis of patients with neurodegenerative disorders using NeuroX arrayNeurovascular defects and faulty amyloid-β vascular clearance in Alzheimer's diseaseReduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations.Rare coding mutations identified by sequencing of Alzheimer disease genome-wide association studies loci.Next generation sequencing of CLU, PICALM and CR1: pitfalls and potential solutions.Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk LociPhenotypic characteristics of Alzheimer patients carrying an ABCA7 mutation.Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in mild cognitive impairment.CLU genetic variants and cognitive decline among elderly and oldest oldAge-dependent effect of Alzheimer's risk variant of CLU on EEG alpha rhythm in non-demented adults.Plasma biomarkers for Alzheimer's disease: much needed but tough to find.Association between clusterin gene polymorphism rs11136000 and late-onset Alzheimer's disease susceptibility: A review and meta-analysis of case-control studies.Clusterin as a therapeutic target.From Common to Rare Variants: The Genetic Component of Alzheimer Disease.Untangling Genetic Risk for Alzheimer's Disease.Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways.Current concepts in Alzheimer's Disease: molecules, models and translational perspectives.Alzheimer disease: modeling an Aβ-centered biological network.Plasma and platelet clusterin ratio is altered in Alzheimer's disease patients with distinct neuropsychiatric symptoms: findings from a pilot study.Genetic Variations in ABCA7 Can Increase Secreted Levels of Amyloid-β40 and Amyloid-β42 Peptides and ABCA7 Transcription in Cell Culture Models.Genetics of dementia in a Finnish cohort.
P2860
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P2860
Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Both common variations and rar ...... with increased Alzheimer risk.
@ast
Both common variations and rar ...... with increased Alzheimer risk.
@en
type
label
Both common variations and rar ...... with increased Alzheimer risk.
@ast
Both common variations and rar ...... with increased Alzheimer risk.
@en
prefLabel
Both common variations and rar ...... with increased Alzheimer risk.
@ast
Both common variations and rar ...... with increased Alzheimer risk.
@en
P2093
P2860
P50
P356
P1476
Both common variations and rar ...... with increased Alzheimer risk.
@en
P2093
Jasper Van Dongen
Karin Peeters
Karolien Bettens
Maria Mattheijssens
Peter P De Deyn
P2860
P2888
P356
10.1186/1750-1326-7-3
P50
P577
2012-01-16T00:00:00Z
P5875
P6179
1008984491