Endotoxin administration to humans inhibits hepatic cytochrome P450-mediated drug metabolism.
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Xenobiotic and Endobiotic Mediated Interactions Between the Cytochrome P450 System and the Inflammatory Response in the LiverTocopherol induced angiogenesis in placental vascular network in late pregnant ewes.TLR4-dependent and -independent regulation of hepatic cytochrome P450 in mice with chemically induced inflammatory bowel disease"Cocktail" approaches and strategies in drug development: valuable tool or flawed science?Immunological response as a source to variability in drug metabolism and transport.A discordance of the cytochrome P450 2C19 genotype and phenotype in patients with advanced cancer.CYP3A-dependent drug metabolism is reduced in bacterial inflammation in micePharmacokinetic variability of anticancer agents.Relationship of ketamine's plasma metabolites with response, diagnosis, and side effects in major depression.Regulation of drug metabolism and disposition during inflammation and infection.Roles of nitric oxide in inflammatory downregulation of human cytochromes P450.Downregulation of drug transport and metabolism in mice bearing extra-hepatic malignancies.Toxicity as a result of immunostimulation by biologics.Drug metabolism alterations in nonalcoholic fatty liver diseaseRecent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.The potential role of transcription factor aryl hydrocarbon receptor in downregulation of hepatic cytochrome P-450 during sepsis.Long-term virus-induced alterations of CYP3A-mediated drug metabolism: a look at the virology, immunology and molecular biology of a multi-faceted problem.The role of hepatic cytochrome P-450 in sepsis.Inflammation-mediated changes in drug transporter expression/activity: implications for therapeutic drug response.Drug disposition in pathophysiological conditions.The effects of gastric bypass surgery on drug absorption and pharmacokinetics.Drug absorption, distribution, metabolism and excretion considerations in critically ill adults.The effect of endotoxin on hepatocyte nuclear factor 1 nuclear protein binding: potential implications on CYP2E1 expression in the rat.Understanding Disease-Drug Interactions in Cancer Patients: Implications for Dosing Within the Therapeutic Window.Age-Related Changes in Hepatic Function: An Update on Implications for Drug Therapy.Impact of physiological, pathological and environmental factors on the expression and activity of human cytochrome P450 2D6 and implications in precision medicine.Development of a Physiologically Based Pharmacokinetic Modelling Approach to Predict the Pharmacokinetics of Vancomycin in Critically Ill Septic Patients.Effect of active infection on cytochrome P450-mediated metabolism of cyclosporine in renal transplant patients.Decreased antipyrine clearance following endotoxin administration: in vivo evidence of the role of nitric oxide.Granulocyte colony-stimulating factor enhances endotoxin-induced decrease in biliary excretion of the antibiotic cefoperazone in rats.Comparative pharmacokinetic study of chlorogenic acid after oral administration of Lonicerae Japonicae Flos and Shuang-Huang-Lian in normal and febrile rats.Higher incidence of elevated body temperature or increased C-reactive protein level in asthmatic children showing transient reduction of theophylline metabolism.Endotoxin-Mediated Downregulation of Hepatic Drug Transporters in HIV-1 Transgenic Rats.Regulation of cytochromes P450 during inflammation and infection.Carvacrol ameliorates the PPAR-A and cytochrome P450 expression on D-galactosamine induced hepatotoxicity rats.Influence of sepsis on the plasma elimination pharmacokinetics of diaspirin crosslinked hemoglobin in rats.Time-variant increase in methylprednisolone clearance in patients with acute respiratory distress syndrome: a population pharmacokinetic study.Scavenging nitric oxide reduces hepatocellular injury after endotoxin challenge.Impairment of cytochrome P-450-dependent liver activity in cirrhotic patients with Helicobacter pylori infection.The temporal relationship between bacterial lipopolysaccharide and monocrotaline exposures influences toxicity: shift in response from hepatotoxicity to nitric oxide-dependent lethality.
P2860
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P2860
Endotoxin administration to humans inhibits hepatic cytochrome P450-mediated drug metabolism.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Endotoxin administration to hu ...... P450-mediated drug metabolism.
@ast
Endotoxin administration to hu ...... P450-mediated drug metabolism.
@en
type
label
Endotoxin administration to hu ...... P450-mediated drug metabolism.
@ast
Endotoxin administration to hu ...... P450-mediated drug metabolism.
@en
prefLabel
Endotoxin administration to hu ...... P450-mediated drug metabolism.
@ast
Endotoxin administration to hu ...... P450-mediated drug metabolism.
@en
P2093
P2860
P356
P1476
Endotoxin administration to hu ...... P450-mediated drug metabolism.
@en
P2093
B C Israel
C J McClain
R A Blouin
S I Shedlofsky
P2860
P304
P356
10.1172/JCI117582
P407
P577
1994-12-01T00:00:00Z