Pharmacokinetics and response to pravastatin in paediatric patients with familial hypercholesterolaemia and in paediatric cardiac transplant recipients in relation to polymorphisms of the SLCO1B1 and ABCB1 genes.

Pharmacokinetics and response to pravastatin in paediatric patients with familial hypercholesterolaemia and in paediatric cardiac transplant recipients in relation to polymorphisms of the SLCO1B1 and ABCB1 genes.

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Development of Human Membrane Transporters: Drug Disposition and Pharmacogenetics Development of biomarkers to optimize pediatric patient management: what makes children different?Pediatric Statin Administration: Navigating a Frontier with Limited Data Pharmacogenetics of OATP transporters reveals that SLCO1B1 c.388A>G variant is determinant of increased atorvastatin response Meta-Analysis of the SLCO1B1 c.521T>C Variant Reveals Slight Influence on the Lipid-Lowering Efficacy of Statins.Rational approach to the treatment for heterozygous familial hypercholesterolemia in childhood and adolescence: a review.Pharmacogenetics of response to statins Pharmacogenetics in clinical pediatrics: challenges and strategies.Genetic polymorphisms of uptake (OATP1B1, 1B3) and efflux (MRP2, BCRP) transporters: implications for inter-individual differences in the pharmacokinetics and pharmacodynamics of statins and other clinically relevant drugs.Hepatic OATP and OCT uptake transporters: their role for drug-drug interactions and pharmacogenetic aspects.Pharmacogenomics of high-density lipoprotein-cholesterol-raising therapies.Clinical response to statins: mechanism(s) of variable activity and adverse effects.Pediatric pharmacogenomics: a systematic assessment of ontogeny and genetic variation to guide the design of statin studies in children.Causes and Consequences of Variability in Drug Transporter Activity in Pediatric Drug Therapy.Mixed effects of OATP1B1, BCRP and NTCP polymorphisms on the population pharmacokinetics of pravastatin in healthy volunteers.Impact of OATP1B1, MDR1, and CYP3A4 expression in liver and intestine on interpatient pharmacokinetic variability of atorvastatin in obese subjects.Cyclosporine inhibition of hepatic and intestinal CYP3A4, uptake and efflux transporters: application of PBPK modeling in the assessment of drug-drug interaction potential.Association between a frequent allele of the gene encoding OATP1B1 and enhanced LDL-lowering response to fluvastatin therapy.Approaches to dyslipidemia treatment in children and adolescents

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P2860

Pharmacokinetics and response to pravastatin in paediatric patients with familial hypercholesterolaemia and in paediatric cardiac transplant recipients in relation to polymorphisms of the SLCO1B1 and ABCB1 genes.

Item

http://www.wikidata.org/entity/Q35827696

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2006 nî lūn-bûn

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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2006年论文

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2006年论文

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name

Pharmacokinetics and response ...... f the SLCO1B1 and ABCB1 genes.

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Pharmacokinetics and response ...... f the SLCO1B1 and ABCB1 genes.

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type

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Pharmacokinetics and response ...... f the SLCO1B1 and ABCB1 genes.

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Pharmacokinetics and response ...... f the SLCO1B1 and ABCB1 genes.

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Pharmacokinetics and response ...... f the SLCO1B1 and ABCB1 genes.

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Pharmacokinetics and response ...... f the SLCO1B1 and ABCB1 genes.

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P1476

Pharmacokinetics and response ...... f the SLCO1B1 and ABCB1 genes.

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P2093

Kari T Kivistö

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Marjatta Antikainen

http://www.w3.org/2001/XMLSchema#string

Mia Hedman

http://www.w3.org/2001/XMLSchema#string

Michel Eichelbaum

http://www.w3.org/2001/XMLSchema#string

Pertti J Neuvonen

http://www.w3.org/2001/XMLSchema#string

P2860

A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters

Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics

Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans

Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation

A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter

High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)

Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter

Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney.

Clinical pharmacokinetics of pravastatin: mechanisms of pharmacokinetic events.

Developmental pharmacology--drug disposition, action, and therapy in infants and children.

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706-715

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scholarly article

P356

10.1111/J.1365-2125.2006.02643.X

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English

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Mikko Niemi

Mikko Neuvonen

Christer Holmberg

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2006-06-01T00:00:00Z

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7059675

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16722833

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hypercholesterolemia

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1885108

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Pharmacokinetics and response to pravastatin in paediatric patients with familial hypercholesterolaemia and in paediatric cardiac transplant recipients in relation to polymorphisms of the SLCO1B1 and ABCB1 genes.

about

P2860

P2860

Pharmacokinetics and response to pravastatin in paediatric patients with familial hypercholesterolaemia and in paediatric cardiac transplant recipients in relation to polymorphisms of the SLCO1B1 and ABCB1 genes.

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