Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol
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Epigenetics and agingSynthesis and Assay of SIRT1-Activating CompoundsResveratrol serves as a protein-substrate interaction stabilizer in human SIRT1 activation.The Synergistic Role of Light-Feeding Phase Relations on Entraining Robust Circadian Rhythms in the Periphery.Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK.Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment.Sirt1 carboxyl-domain is an ATP-repressible domain that is transferrable to other proteins.Using mitochondrial sirtuins as drug targets: disease implications and available compounds.Resveratrol: How Much Wine Do You Have to Drink to Stay Healthy?Microglial CX3CR1 promotes adult neurogenesis by inhibiting Sirt 1/p65 signaling independent of CX3CL1Lysine Deacetylases Exhibit Distinct Changes in Activity Profiles Due to Fluorophore Conjugation of Substrates.The Current State of NAD(+) -Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets.KDAC8 substrate specificity quantified by a biologically relevant, label-free deacetylation assay.Identification of a Tissue-Restricted Isoform of SIRT1 Defines a Regulatory Domain that Encodes Specificity.SIRT1-dependent modulation of methylation and acetylation of histone H3 on lysine 9 (H3K9) in the zygotic pronuclei improves porcine embryo development.Obesity-Linked Phosphorylation of SIRT1 by Casein Kinase 2 Inhibits Its Nuclear Localization and Promotes Fatty Liver.Mechanism of Sirt1 NAD+-dependent Protein Deacetylase Inhibition by Cysteine S-Nitrosation.Mathematical Analysis of Circadian Disruption and Metabolic Re-entrainment of Hepatic Gluconeogenesis: The intertwining entraining roles of light and feeding.Impact of sirtuin-1 expression on H3K56 acetylation and oxidative stress: a double-blind randomized controlled trial with resveratrol supplementation.Not an exception to the rule: the functional significance of intrinsically disordered protein regions in enzymes.Polypharmacology or Promiscuity? Structural Interactions of Resveratrol With Its Bandwagon of TargetsElectroacupuncture: A Feasible Sirt1 Promoter Which Modulates Metainflammation in Diet-Induced Obesity RatsMetformin Is a Direct SIRT1-Activating Compound: Computational Modeling and Experimental Validation
P2860
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P2860
Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Structural basis for allosteri ...... SIRT1 activity by resveratrol
@ast
Structural basis for allosteri ...... SIRT1 activity by resveratrol
@en
type
label
Structural basis for allosteri ...... SIRT1 activity by resveratrol
@ast
Structural basis for allosteri ...... SIRT1 activity by resveratrol
@en
prefLabel
Structural basis for allosteri ...... SIRT1 activity by resveratrol
@ast
Structural basis for allosteri ...... SIRT1 activity by resveratrol
@en
P2093
P2860
P356
P1433
P1476
Structural basis for allosteri ...... SIRT1 activity by resveratrol
@en
P2093
Dongxiang Liu
Duanfang Cao
Hualiang Jiang
Mingzhu Wang
Rui-Ming Xu
Xiayang Qiu
P2860
P304
P356
10.1101/GAD.265462.115
P577
2015-06-01T00:00:00Z