Charged residues between the selectivity filter and S6 segments contribute to the permeation phenotype of the sodium channel.
about
Using the deadly mu-conotoxins as probes of voltage-gated sodium channelsTwo sets of amino acids of the domain I of Cav2.3 Ca(2+) channels contribute to their high sensitivity to extracellular protonsConstraint shapes convergence in tetrodotoxin-resistant sodium channels of snakesEnergetic localization of saxitoxin in its channel binding site.Novel interactions identified between micro -Conotoxin and the Na+ channel domain I P-loop: implications for toxin-pore binding geometry.A ring of eight conserved negatively charged amino acids doubles the conductance of BK channels and prevents inward rectification.Molecular insights into ion channel function (Review).Molecular architecture of the voltage-dependent Na channel: functional evidence for alpha helices in the pore.Clockwise domain arrangement of the sodium channel revealed by (mu)-conotoxin (GIIIA) docking orientation.Conotoxins as sensors of local pH and electrostatic potential in the outer vestibule of the sodium channel.Charge conversion enables quantification of the proximity between a normally-neutral mu-conotoxin (GIIIA) site and the Na+ channel pore.Role of outer ring carboxylates of the rat skeletal muscle sodium channel pore in proton block.Differences in apparent pore sizes of low and high voltage-activated Ca2+ channels.An external determinant in the S5-P linker of the pacemaker (HCN) channel identified by sulfhydryl modification.Molecular basis of isoform-specific micro-conotoxin block of cardiac, skeletal muscle, and brain Na+ channels.Molecular basis of the effect of potassium on heterologously expressed pacemaker (HCN) channels.Dependence of mu-conotoxin block of sodium channels on ionic strength but not on the permeating [Na+]: implications for the distinctive mechanistic interactions between Na+ and K+ channel pore-blocking toxins and their molecular targets.
P2860
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P2860
Charged residues between the selectivity filter and S6 segments contribute to the permeation phenotype of the sodium channel.
description
2000 nî lūn-bûn
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2000年の論文
@ja
2000年論文
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2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
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2000年论文
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2000年论文
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name
Charged residues between the s ...... enotype of the sodium channel.
@ast
Charged residues between the s ...... enotype of the sodium channel.
@en
type
label
Charged residues between the s ...... enotype of the sodium channel.
@ast
Charged residues between the s ...... enotype of the sodium channel.
@en
prefLabel
Charged residues between the s ...... enotype of the sodium channel.
@ast
Charged residues between the s ...... enotype of the sodium channel.
@en
P2093
P2860
P356
P1476
Charged residues between the s ...... enotype of the sodium channel.
@en
P2093
G F Tomaselli
N Chiamvimonvat
P2860
P356
10.1085/JGP.115.1.81
P577
2000-01-01T00:00:00Z