A phase I trial of pan-Bcl-2 antagonist obatoclax administered as a 3-h or a 24-h infusion in combination with carboplatin and etoposide in patients with extensive-stage small cell lung cancer
about
Targeting BCL2-Proteins for the Treatment of Solid TumoursMitochondrial apoptosis and BH3 mimeticsClinical profiling of BCL-2 family members in the setting of BRAF inhibition offers a rationale for targeting de novo resistance using BH3 mimetics.Implementation of validated pharmacodynamic assays in multiple laboratories: challenges, successes, and limitations.Pan-Bcl-2 inhibitor, GX15-070 (obatoclax), decreases human T regulatory lymphocytes while preserving effector T lymphocytes: a rationale for its use in combination immunotherapyTargeted therapies in small cell lung cancer: a reviewHost-based Prophylaxis Successfully Targets Liver Stage Malaria Parasites.Mechanistic rationale for MCL1 inhibition during androgen deprivation therapy.Combined inhibition of Bcl-2/Bcl-xL and Usp9X/Bag3 overcomes apoptotic resistance in glioblastoma in vitro and in vivo.Obatoclax mesylate, a pan-bcl-2 inhibitor, in combination with docetaxel in a phase 1/2 trial in relapsed non-small-cell lung cancer.Attacking cancer's Achilles heel: antagonism of anti-apoptotic BCL-2 family membersHistone deacetylase inhibitors restore toxic BH3 domain protein expression in anoikis-resistant mammary and brain cancer stem cells, thereby enhancing the response to anti-ERBB1/ERBB2 therapy.Progress in the management of limited-stage small cell lung cancer.Cell death and the mitochondria: therapeutic targeting of the BCL-2 family-driven pathway.The mystery of BCL2 family: Bcl-2 proteins and apoptosis: an update.Ganetespib for small cell lung cancer.Single-agent obatoclax (GX15-070) potently induces apoptosis and pro-survival autophagy in head and neck squamous cell carcinoma cells.Anti-cancer drug discovery and development: Bcl-2 family small molecule inhibitors.The Bcl-2 inhibitor Obatoclax overcomes resistance to histone deacetylase inhibitors SAHA and LBH589 as radiosensitizers in patient-derived glioblastoma stem-like cells.RFX-1-dependent activation of SHP-1 inhibits STAT3 signaling in hepatocellular carcinoma cells.A Non-apoptotic Function of MCL-1 in Promoting Pluripotency and Modulating Mitochondrial Dynamics in Stem Cells.
P2860
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P2860
A phase I trial of pan-Bcl-2 antagonist obatoclax administered as a 3-h or a 24-h infusion in combination with carboplatin and etoposide in patients with extensive-stage small cell lung cancer
description
2012 nî lūn-bûn
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年论文
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2012年论文
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2012年论文
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name
A phase I trial of pan-Bcl-2 a ...... e-stage small cell lung cancer
@ast
A phase I trial of pan-Bcl-2 a ...... e-stage small cell lung cancer
@en
type
label
A phase I trial of pan-Bcl-2 a ...... e-stage small cell lung cancer
@ast
A phase I trial of pan-Bcl-2 a ...... e-stage small cell lung cancer
@en
prefLabel
A phase I trial of pan-Bcl-2 a ...... e-stage small cell lung cancer
@ast
A phase I trial of pan-Bcl-2 a ...... e-stage small cell lung cancer
@en
P2093
P2860
P356
P1476
A phase I trial of pan-Bcl-2 a ...... e-stage small cell lung cancer
@en
P2093
A A Chiappori
D S Subramaniam
J J Stephenson
J Schnyder
M S Berger
M T Schreeder
P2860
P2888
P304
P356
10.1038/BJC.2012.21
P407
P577
2012-02-14T00:00:00Z