Catalysis of DNA cleavage and nucleoside triphosphate synthesis by NM23-H2/NDP kinase share an active site that implies a DNA repair function
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NM23-H1 tumor suppressor physically interacts with serine-threonine kinase receptor-associated protein, a transforming growth factor-beta (TGF-beta) receptor-interacting protein, and negatively regulates TGF-beta signalingDirect evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcriptionMetastases suppressor NM23-H2 interaction with G-quadruplex DNA within c-MYC promoter nuclease hypersensitive element induces c-MYC expressionNucleoside diphosphate kinase from Mycobacterium tuberculosis cleaves single strand DNA within the human c-myc promoter in an enzyme-catalyzed reactionStructural and biochemical insights into the dicing mechanism of mouse Dicer: A conserved lysine is critical for dsRNA cleavageNM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III1A covalent protein-DNA 5'-product adduct is generated following AP lyase activity of human ALKBH1 (AlkB homologue 1)Nuclear localization and in situ DNA damage by Mycobacterium tuberculosis nucleoside-diphosphate kinaseNM23-H1 and NM23-H2 repress transcriptional activities of nuclease-hypersensitive elements in the platelet-derived growth factor-A promoter.Proteomic approach to identification of proteins reactive for abasic sites in DNA.Escherichia coli nucleoside diphosphate kinase does not act as a uracil-processing DNA repair nuclease.Metastasis suppressor NM23-H1 promotes repair of UV-induced DNA damage and suppresses UV-induced melanomagenesis.Sptrx-2, a fusion protein composed of one thioredoxin and three tandemly repeated NDP-kinase domains is expressed in human testis germ cells.Metastasis suppressor function of NM23-H1 requires its 3'-5' exonuclease activity.Making sense of G-quadruplex and i-motif functions in oncogene promoters.Apurinic/apyrimidinic (AP) site recognition by the 5'-dRP/AP lyase in poly(ADP-ribose) polymerase-1 (PARP-1)Escherichia coli strains (ndk) lacking nucleoside diphosphate kinase are powerful mutators for base substitutions and frameshifts in mismatch-repair-deficient strainsHIV DNA is heavily uracilated, which protects it from autointegrationSwoHp, a nucleoside diphosphate kinase, is essential in Aspergillus nidulans.Pro-oncogenic potential of NM23-H2 in hepatocellular carcinomaThe relationship between dNTP pool levels and mutagenesis in an Escherichia coli NDP kinase mutant.Characterization of the 3' --> 5' exonuclease activity found in human nucleoside diphosphate kinase 1 (NDK1) and several of its homologues.Escherichia coli nucleoside diphosphate kinase is a uracil-processing DNA repair nucleaseStructure and Function of the Small MutS-Related Domain.Regulatory functions of Nm23-H2 in tumorigenesis: insights from biochemical to clinical perspectives.Molecular and functional interactions between Escherichia coli nucleoside-diphosphate kinase and the uracil-DNA glycosylase Ung.Chemical Approaches to Studying Labile Amino Acid Phosphorylation.Oligoribonuclease is a common downstream target of lithium-induced pAp accumulation in Escherichia coli and human cells.Evidence of EGR1 as a differentially expressed gene among proliferative skin diseases.Intermolecular phosphotransfer is crucial for efficient catalytic activity of nucleoside diphosphate kinase.Interactions between Escherichia coli nucleoside-diphosphate kinase and DNA.12-O-tetradecanoylphorbol-13-acetate and UV radiation-induced nucleoside diphosphate protein kinase B mediates neoplastic transformation of epidermal cells.Escherichia coli nucleoside diphosphate kinase interactions with T4 phage proteins of deoxyribonucleotide synthesis and possible regulatory functions.Structure and mutational analysis of a plant mitochondrial nucleoside diphosphate kinase. Identification of residues involved in serine phosphorylation and oligomerization.Trypanosoma cruzi nucleoside diphosphate kinase 1 ( TcNDPK1) has a broad nuclease activity.Biochemical Characterization of AP Lyase and m6A Demethylase Activities of Human AlkB Homologue 1 (ALKBH1)."Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates.Discovery of novel inhibitors for Leishmania nucleoside diphosphatase kinase (NDK) based on its structural and functional characterization.A critical evaluation of biochemical activities reported for the nucleoside diphosphate kinase/Nm23/Awd family proteins: opportunities and missteps in understanding their biological functions.NM23-H2, an estrogen receptor β-associated protein, shows diminished expression with progression of atherosclerosis
P2860
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P2860
Catalysis of DNA cleavage and nucleoside triphosphate synthesis by NM23-H2/NDP kinase share an active site that implies a DNA repair function
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Catalysis of DNA cleavage and ...... implies a DNA repair function
@ast
Catalysis of DNA cleavage and ...... implies a DNA repair function
@en
type
label
Catalysis of DNA cleavage and ...... implies a DNA repair function
@ast
Catalysis of DNA cleavage and ...... implies a DNA repair function
@en
prefLabel
Catalysis of DNA cleavage and ...... implies a DNA repair function
@ast
Catalysis of DNA cleavage and ...... implies a DNA repair function
@en
P2093
P2860
P356
P1476
Catalysis of DNA cleavage and ...... implies a DNA repair function
@en
P2093
P2860
P304
14194-14199
P356
10.1073/PNAS.97.26.14194
P407
P577
2000-12-01T00:00:00Z