Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution.
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Genomics, microRNA, epigenetics, and proteomics for future diagnosis, treatment and monitoring response in upper GI cancersEpithelial-to-mesenchymal plasticity of cancer stem cells: therapeutic targets in hepatocellular carcinomaThe Global Relationship between Chromatin Physical Topology, Fractal Structure, and Gene ExpressionBioinformatics and Drug Discovery.Excess of mutational jackpot events in expanding populations revealed by spatial Luria-Delbrück experiments.Measuring intratumor heterogeneity by network entropy using RNA-seq data.Rational design of non-resistant targeted cancer therapiesLow-Dose Dose-Response for In Vitro Nrf2-ARE Activation in Human HepG2 CellsUltrasensitive and high-efficiency screen of de novo low-frequency mutations by o2n-seq.Multi-omics study revealing the complexity and spatial heterogeneity of tumor-infiltrating lymphocytes in primary liver carcinoma.Identification of trunk mutations in gastric carcinoma: a case studyStability of Cross-Feeding Polymorphisms in Microbial CommunitiesPunctuated copy number evolution and clonal stasis in triple-negative breast cancer.An exactly solvable, spatial model of mutation accumulation in cancerThe spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma.Neutral tumor evolution in myeloma is associated with poor prognosis.Genomic and Epigenomic Aberrations in Esophageal Squamous Cell Carcinoma and Implications for Patients.Evaluating optimal therapy robustness by virtual expansion of a sample population, with a case study in cancer immunotherapy.Computational Methods for Characterizing Cancer Mutational Heterogeneity.Between-region genetic divergence reflects the mode and tempo of tumor evolution.Advances in understanding tumour evolution through single-cell sequencing.A Direct Test of Selection in Cell Populations Using the Diversity in Gene Expression within Tumors.New paradigms in clonal evolution: punctuated equilibrium in cancer.A key to the backdoor into the castle: The clinical ramifications of immunoediting driven by antigenic competitionTumor evolution: Linear, branching, neutral or punctuated?Catch my drift? Making sense of genomic intra-tumour heterogeneity.Tissue disruption increases stochastic gene expression thus producing tumors: Cancer initiation without driver mutation.Natural Selection in Cancer Biology: From Molecular Snowflakes to Trait Hallmarks.The evolution of tumour phylogenetics: principles and practice.A population genetics perspective on the determinants of intra-tumor heterogeneity.New insights into the earliest stages of colorectal tumorigenesis.Functional versus non-functional intratumor heterogeneity in cancer.Evolutionary dynamics and significance of multiple subclonal mutations in cancer.Subclonal diversity arises early even in small colorectal tumours and contributes to differential growth fates.Cancer adaptations: Atavism, de novo selection, or something in between?First-in-Human Phase 1 Trial of Agarose Beads Containing Murine RENCA Cells in Advanced Solid Tumors.Heterogeneity-mediated cellular adaptation and its trade-off: searching for the general principles of diseases.Non-cell-autonomous effects yield lower clonal diversity in expanding tumors.Multiregional Tumor Trees Are Not Phylogenies.Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing.
P2860
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P2860
Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Extremely high genetic diversi ...... non-Darwinian cell evolution.
@ast
Extremely high genetic diversi ...... non-Darwinian cell evolution.
@en
type
label
Extremely high genetic diversi ...... non-Darwinian cell evolution.
@ast
Extremely high genetic diversi ...... non-Darwinian cell evolution.
@en
prefLabel
Extremely high genetic diversi ...... non-Darwinian cell evolution.
@ast
Extremely high genetic diversi ...... non-Darwinian cell evolution.
@en
P2093
P2860
P50
P356
P1476
Extremely high genetic diversi ...... non-Darwinian cell evolution.
@en
P2093
Chung-I Wu
Chunyi Hao
Daniel V T Catenacci
Eric A Hungate
Lingtong Hao
P2860
P304
P356
10.1073/PNAS.1519556112
P407
P577
2015-11-11T00:00:00Z