Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice.
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PDE4 inhibitors as potential therapeutic agents in the treatment of COPD-focus on roflumilastModels of chronic obstructive pulmonary diseaseNeutrophil elastase and matrix metalloproteinase 12 in cystic fibrosis lung diseaseX-ray Snapshot of the Mechanism of Inactivation of Human Neutrophil Elastase by 1,2,5-Thiadiazolidin-3-one 1,1-Dioxide Derivatives †Potent and Selective Human Neutrophil Elastase Inhibitors with Novel Equatorial Ring Topology: in vivo Efficacy of the Polar Pyrimidopyridazine BAY-8040 in a Pulmonary Arterial Hypertension Rat ModelNeutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growthNeu-164 and Neu-107, two novel antioxidant and anti-myeloperoxidase compounds, inhibit acute cigarette smoke-induced lung inflammationNeutrophil elastase-initiated EGFR/MEK/ERK signaling counteracts stabilizing effect of autocrine TGF-beta on tropoelastin mRNA in lung fibroblastsFreezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary DiseasesMatrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection.Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin.Neutrophil elastase cleaves epithelial cadherin in acutely injured lung epitheliumComparison of two quantitative methods of discerning airspace enlargement in smoke-exposed mice.Utilization of the 1,2,3,5-thiatriazolidin-3-one 1,1-dioxide scaffold in the design of potential inhibitors of human neutrophil proteinase 3.Plant Proteinase Inhibitor BbCI Modulates Lung Inflammatory Responses and Mechanic and Remodeling Alterations Induced by Elastase in Mice.Effects of the common polymorphism in the human aldehyde dehydrogenase 2 (ALDH2) gene on the lungCigarette smoke exposure during pregnancy alters fetomaternal cell trafficking leading to retention of microchimeric cells in the maternal lung.Protein kinase C zeta mediates cigarette smoke/aldehyde- and lipopolysaccharide-induced lung inflammation and histone modifications.The role of matrix metalloproteinase-9 in cigarette smoke-induced emphysema.Mechanism-based inhibitors of serine proteases with high selectivity through optimization of S' subsite binding.Surfactant protein-d inhibits lung inflammation caused by ventilation in premature newborn lambsEmphysema mediated by lung overexpression of ADAM10.Role of th17 cell and autoimmunity in chronic obstructive pulmonary disease.Anti-inflammatory role of the cAMP effectors Epac and PKA: implications in chronic obstructive pulmonary diseaseBlockade of neutrophil elastase attenuates severe liver injury in hepatitis B transgenic miceElastin fragments drive disease progression in a murine model of emphysemaThe SERPINE2 gene is associated with chronic obstructive pulmonary disease.Lack of neutrophil elastase reduces inflammation, mucus hypersecretion, and emphysema, but not mucus obstruction, in mice with cystic fibrosis-like lung disease.gammadelta T cells regulate the early inflammatory response to bordetella pertussis infection in the murine respiratory tract.Lysyl oxidase, a critical intra- and extra-cellular target in the lung for cigarette smoke pathogenesis.Effect of an MMP-9/MMP-12 inhibitor on smoke-induced emphysema and airway remodelling in guinea pigs.PlGF mediates neutrophil elastase-induced airway epithelial cell apoptosis and emphysemaDifferential expression and function of breast regression protein 39 (BRP-39) in murine models of subacute cigarette smoke exposure and allergic airway inflammation.FRET-based and other fluorescent proteinase probes.Role of elastases in the pathogenesis of chronic obstructive pulmonary disease: implications for treatmentThe serine protease inhibitor elafin maintains normal growth control by opposing the mitogenic effects of neutrophil elastase.The receptor for advanced glycation end products (RAGE) contributes to the progression of emphysema in miceRETRACTED: NAD(P)H:quinone oxidoreductase 1 protects lungs from oxidant-induced emphysema in mice.Heme oxygenase-1-mediated autophagy protects against pulmonary endothelial cell death and development of emphysema in cadmium-treated miceCoordinate activation of inflammatory gene networks, alveolar destruction and neonatal death in AKNA deficient mice.
P2860
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P2860
Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice.
@ast
Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice.
@en
type
label
Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice.
@ast
Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice.
@en
prefLabel
Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice.
@ast
Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice.
@en
P2093
P2860
P1476
Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice.
@en
P2093
A McGarry Houghton
Abderazzaq Belaaouaj
Dale K Kobayashi
Diane Kelley
Nir M Goldstein
Steven D Shapiro
P2860
P304
P356
10.1016/S0002-9440(10)63589-4
P407
P577
2003-12-01T00:00:00Z