Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis.
about
Genome-wide association analysis of metabolic traits in a birth cohort from a founder populationInduction of Neuron-Specific Degradation of Coenzyme A Models Pantothenate Kinase-Associated Neurodegeneration by Reducing Motor Coordination in MiceCofilin/Twinstar phosphorylation levels increase in response to impaired coenzyme a metabolismModulation of Pantothenate Kinase 3 Activity by Small Molecules that Interact with the Substrate/Allosteric Regulatory DomainPantothenate kinase 1 is required to support the metabolic transition from the fed to the fasted stateGermline deletion of pantothenate kinases 1 and 2 reveals the key roles for CoA in postnatal metabolismLocalization and regulation of mouse pantothenate kinase 2Compartmentalization of mammalian pantothenate kinasesGenetic Characterization of Coenzyme A Biosynthesis Reveals Essential Distinctive Functions during Malaria Parasite Development in Blood and Mosquito.Pantethine rescues a Drosophila model for pantothenate kinase-associated neurodegenerationBrain, blood, and iron: perspectives on the roles of erythrocytes and iron in neurodegeneration.Postprandial regulation of hepatic microRNAs predicted to target the insulin pathway in rainbow trout.A liver-specific defect of Acyl-CoA degradation produces hyperammonemia, hypoglycemia and a distinct hepatic Acyl-CoA patternPank1 deletion in leptin-deficient mice reduces hyperglycaemia and hyperinsulinaemia and modifies global metabolism without affecting insulin resistanceLiving on the edge: substrate competition explains loss of robustness in mitochondrial fatty-acid oxidation disorders.Vitamin B5 and N-Acetylcysteine in Nonalcoholic Steatohepatitis: A Preclinical Study in a Dietary Mouse Model.Correction of a genetic deficiency in pantothenate kinase 1 using phosphopantothenate replacement therapy.Deregulated coenzyme A, loss of metabolic flexibility and diabetes.Metabolic activation of CaMKII by coenzyme A.Glycine conjugation: importance in metabolism, the role of glycine N-acyltransferase, and factors that influence interindividual variation.A new perspective on the importance of glycine conjugation in the metabolism of aromatic acids.Coenzyme A, more than 'just' a metabolic cofactor.Exploiting the coenzyme A biosynthesis pathway for the identification of new antimalarial agents: the case for pantothenamides.Methods for measuring CoA and CoA derivatives in biological samples.Extracellular 4'-phosphopantetheine is a source for intracellular coenzyme A synthesis.Excess coenzyme A reduces skeletal muscle performance and strength in mice overexpressing human PANK2.Impaired Coenzyme A metabolism affects histone and tubulin acetylation in Drosophila and human cell models of pantothenate kinase associated neurodegeneration.Allosteric Regulation of Mammalian Pantothenate Kinase.Acetyl-4'-phosphopantetheine is stable in serum and prevents phenotypes induced by pantothenate kinase deficiency.Pantothenate kinase-associated neurodegeneration: insights from a Drosophila model.De novo CoA biosynthesis is required to maintain DNA integrity during development of the Drosophila nervous system.PanK4 inhibits pancreatic beta-cell apoptosis by decreasing the transcriptional level of pro-caspase-9.Nudt19 is a renal CoA diphosphohydrolase with biochemical and regulatory properties that are distinct from the hepatic Nudt7 isoform.Variation in pantothenate kinase type determines the pantothenamide mode of action and impacts on coenzyme A salvage biosynthesis.A framework for large-scale metabolome drug profiling links coenzyme A metabolism to the toxicity of anti-cancer drug dichloroacetateA therapeutic approach to pantothenate kinase associated neurodegeneration
P2860
Q24654676-ED26EE36-5402-4FEF-9698-423B49DEB382Q27304502-F5F28078-F54C-4DE6-8DD0-A42C8FB9ED31Q27323698-156C6297-D4EF-42C7-826E-74544898FB0EQ27664193-5712C215-A15A-4613-8EC1-92012195E52BQ28474360-E17AEB4A-F150-445B-B27A-1671ADD2EFD6Q28509589-8FBD6CEB-C103-473F-BECE-49E605D5A5DDQ28588917-11D820E0-CB56-4974-91B4-41FD91A57754Q28593602-8E1CF7C4-3C83-4083-9AF3-6322BD25AFEEQ33813204-5C46F56F-FB13-40C1-A84D-EC02C43BA9DFQ33859513-A9AB0D5E-6FDB-4692-AB15-ADC8EE6B1F25Q34198997-E4CF2255-DB7A-40A7-94C4-0D7AED20A25CQ34305614-82659FF7-F5F7-4FBC-93AE-B244920D9151Q34825139-53F329D1-39B9-4446-9E0A-89288B5383C6Q36201396-F95CF052-741A-4188-B43C-3ABEAAC56A56Q36215331-3DDB6D25-2F58-4345-A2FD-053A6CF51A7FQ36437061-5C0B2EF3-EDDA-47A1-8B41-7F3AEC7C5DE8Q36608623-6E8D498F-1C22-4366-A851-398F74CC992DQ37108651-D1CF7E4C-82F8-4B83-BC03-7BB4441536A4Q37667099-7203E08A-582B-4778-AC3C-1B843A0ABEABQ38104736-C963604E-A03D-4C07-B730-FBED38390532Q38206257-883A6149-DF96-41B9-A911-FA7CEFFC66EEQ38238657-29073A57-C670-4E4C-916C-FA5F47F15BA8Q38238661-004500AD-8546-464C-AF3E-AC3914A246B6Q38238664-A8CB9C4D-4730-4E27-9010-2B3B582047E1Q38839395-79AFFF5C-5AFC-4118-A5DA-5E9379239455Q38965702-085681D5-507D-463F-BB1B-95BA75D20EACQ39697606-4A22B013-5DAB-45A1-B3E5-90CB50F7165DQ40565067-D8C6F2E6-B1E7-4FEA-AED9-7D923DF20C38Q41199152-4CEDE95B-C49E-436D-B902-5CC5F65CD7DBQ45929301-2238EFFF-7522-4B75-92CC-254CFED71F43Q46648320-DD43172D-52E4-4379-80ED-B631F82BBD79Q46922852-6D8BED87-2DBF-488F-87EC-416A172C1165Q49597537-E4BA26E9-5E3C-4567-A58D-74A665F50F24Q53831352-DFB593E3-6C0D-4D64-B146-CF635C96EB84Q57135523-0F4A53D4-1C3D-4FF7-8E24-7C68600C38C1Q57798886-4C0CA75D-3E7B-4EE5-ADDD-39DE856A10AE
P2860
Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Chemical knockout of pantothen ...... epatic coenzyme A homeostasis.
@ast
Chemical knockout of pantothen ...... epatic coenzyme A homeostasis.
@en
type
label
Chemical knockout of pantothen ...... epatic coenzyme A homeostasis.
@ast
Chemical knockout of pantothen ...... epatic coenzyme A homeostasis.
@en
prefLabel
Chemical knockout of pantothen ...... epatic coenzyme A homeostasis.
@ast
Chemical knockout of pantothen ...... epatic coenzyme A homeostasis.
@en
P2093
P2860
P50
P1476
Chemical knockout of pantothen ...... epatic coenzyme A homeostasis.
@en
P2093
Brett R Wenner
Charles O Rock
Christopher B Newgard
Kristopher G Virga
Olga R Ilkayeva
Robert D Stevens
Shigeru Chohnan
Yong-Mei Zhang
P2860
P304
P356
10.1016/J.CHEMBIOL.2007.01.013
P577
2007-03-01T00:00:00Z