Altered regulation of beta-like globin genes by a redesigned erythroid transcription factor
about
Extrinsic and intrinsic control by EKLF (KLF1) within a specialized erythroid niche.Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Kruppel-like factor.Recombinant erythroid Kruppel-like factor fused to GATA1 up-regulates delta- and gamma-globin expression in erythroid cellsErythroid Kruppel-like factor (EKLF) is recruited to the gamma-globin gene promoter as a co-activator and is required for gamma-globin gene induction by short-chain fatty acid derivativesThe DEK Oncoprotein Is a Critical Component of the EKLF/KLF1 Enhancer in Erythroid Cells.Neutralizing the function of a β-globin-associated cis-regulatory DNA element using an artificial zinc finger DNA-binding domain.Neomorphic effects of the neonatal anemia (Nan-Eklf) mutation contribute to deficits throughout development.Novel role for EKLF in megakaryocyte lineage commitment.
P2860
Q33666771-A9A9221B-9B1B-473F-9C0C-2B7DB01779AEQ34093648-20CE43E7-9633-42C8-BA54-2BF6D97CB084Q34707219-C5725EDA-7759-4FE3-808C-C7B8B92E866FQ35596693-3762B9A4-5590-4C5D-9241-ED5BF033B2FFQ36109366-A5B1557A-4CB5-4ABB-9482-48A6DEDE6894Q36397827-413ED9C1-D759-4604-A4F0-8D9BAA4BD37DQ38988198-9D5E84AD-A34D-4A37-8C4B-C53CA4A8499EQ40090214-96D4AC75-67C4-498A-A159-4E439CA7B91C
P2860
Altered regulation of beta-like globin genes by a redesigned erythroid transcription factor
description
2007 nî lūn-bûn
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2007年の論文
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2007年学术文章
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2007年学术文章
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2007年学术文章
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2007年学术文章
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name
Altered regulation of beta-lik ...... erythroid transcription factor
@ast
Altered regulation of beta-lik ...... erythroid transcription factor
@en
type
label
Altered regulation of beta-lik ...... erythroid transcription factor
@ast
Altered regulation of beta-lik ...... erythroid transcription factor
@en
prefLabel
Altered regulation of beta-lik ...... erythroid transcription factor
@ast
Altered regulation of beta-lik ...... erythroid transcription factor
@en
P2093
P2860
P1476
Altered regulation of beta-lik ...... erythroid transcription factor
@en
P2093
Deepa Manwani
James J Bieker
Mariann Galdass
P2860
P356
10.1016/J.EXPHEM.2006.09.004
P577
2007-01-01T00:00:00Z