Discovery and Characterization of a Water-Soluble Prodrug of a Dual Inhibitor of Bacterial DNA Gyrase and Topoisomerase IV.

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The Prodrug Approach: A Successful Tool for Improving Drug Solubility In vitro and in vivo activities of DS-2969b, a novel GyrB inhibitor, and its water-soluble prodrug, DS11960558, against methicillin-resistant Staphylococcus aureus.

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Discovery and Characterization of a Water-Soluble Prodrug of a Dual Inhibitor of Bacterial DNA Gyrase and Topoisomerase IV.

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2015 nî lūn-bûn

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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2015年论文

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Discovery and Characterization ...... A Gyrase and Topoisomerase IV.

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Discovery and Characterization ...... A Gyrase and Topoisomerase IV.

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Discovery and Characterization ...... A Gyrase and Topoisomerase IV.

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Discovery and Characterization ...... A Gyrase and Topoisomerase IV.

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Discovery and Characterization ...... A Gyrase and Topoisomerase IV.

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Discovery and Characterization ...... A Gyrase and Topoisomerase IV.

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Discovery and Characterization ...... A Gyrase and Topoisomerase IV.

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Anne-Laure Grillot

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Arnaud Le Tiran

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Bin Song

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Brian L Hanzelka

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Colleen F O'Brien

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Dainius Macikenas

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David P Nicolau

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Dean E Shannon

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Hardwin O'Dowd

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Jared L Crandon

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P2860

DNA gyrase, topoisomerase IV, and the 4-quinolones

Second-generation antibacterial benzimidazole ureas: discovery of a preclinical candidate with reduced metabolic liability

Use of broad-spectrum antimicrobials for the treatment of pneumonia in seriously ill patients: maximizing clinical outcomes and minimizing selection of resistant organisms

Phosphorylated morpholine acetal human neurokinin-1 receptor antagonists as water-soluble prodrugs

Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 1. Prediction of intestinal absorption

Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America

In vitro characterization of the antibacterial spectrum of novel bacterial type II topoisomerase inhibitors of the aminobenzimidazole class.

Intravenous/oral sequential therapy in patients hospitalised with community-acquired pneumonia: which patients, when and what agents?

Nosocomial pneumonia: the importance of a de-escalating strategy for antibiotic treatment of pneumonia in the ICU.

Appropriate empirical antibacterial therapy for nosocomial infections: getting it right the first time.

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10.1021/ACSMEDCHEMLETT.5B00196

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Discovery and Characterization of a Water-Soluble Prodrug of a Dual Inhibitor of Bacterial DNA Gyrase and Topoisomerase IV.

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P2860

P2860

Discovery and Characterization of a Water-Soluble Prodrug of a Dual Inhibitor of Bacterial DNA Gyrase and Topoisomerase IV.

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