Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging - Wikidata - awgldk - TriplyDB

Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging

Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging

http://www.wikidata.org/entity/Q35845272

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Human conditions of insulin-like growth factor-I (IGF-I) deficiency Mitochondria and cardiovascular aging NADPH oxidases: key modulators in aging and age-related cardiovascular diseases?HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents Testing the oxidative stress hypothesis of aging in primate fibroblasts: is there a correlation between species longevity and cellular ROS production?Cerebral microhemorrhages: mechanisms, consequences, and prevention.Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype.Impaired vascular endothelial growth factor A and inflammation in patients with peripheral artery disease.Insulin-like growth factor 1 physiology: lessons from mouse models.Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats.Determination of the total mass of antioxidant substances and antioxidant capacity per unit mass in serum using redox titration.Obesity in aging exacerbates blood-brain barrier disruption, neuroinflammation, and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer's disease.Growth hormone alters the glutathione S-transferase and mitochondrial thioredoxin systems in long-living Ames dwarf mice.Insulin-like growth factor-1 regulates glutathione peroxidase expression and activity in vascular endothelial cells: Implications for atheroprotective actions of insulin-like growth factor-1.Reversal of age-related learning deficiency by the vertebrate PACAP and IGF-1 in a novel invertebrate model of aging: the pond snail (Lymnaea stagnalis).Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice.Resveratrol treatment rescues neurovascular coupling in aged mice: role of improved cerebromicrovascular endothelial function and downregulation of NADPH oxidase.IGF-1 deficiency impairs cerebral myogenic autoregulation in hypertensive mice Endothelin-1-induced focal cerebral ischemia in the growth hormone/IGF-1 deficient Lewis Dwarf rat.Reductions in serum IGF-1 during aging impair health span.Resveratrol encapsulated in novel fusogenic liposomes activates Nrf2 and attenuates oxidative stress in cerebromicrovascular endothelial cells from aged rats.Age-related decline of autocrine pituitary adenylate cyclase-activating polypeptide impairs angiogenic capacity of rat cerebromicrovascular endothelial cells.Growth hormone and IGF-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese Lewis dwarf rats: implications for vascular aging The emerging role of IGF-1 deficiency in cardiovascular aging: recent advances Aging, atherosclerosis, and IGF-1 Diverse roles of growth hormone and insulin-like growth factor-1 in mammalian aging: progress and controversies.Disruption of Nrf2 signaling impairs angiogenic capacity of endothelial cells: implications for microvascular aging.Vitamin D modulates the association of circulating insulin-like growth factor-1 with carotid artery intima-media thickness.IGF-1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging Age-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: reversal by resveratrol treatment.Diverging antioxidative responses to IGF-1 in cultured human skin fibroblasts versus vascular endothelial cells.SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2.Circulating factors induced by caloric restriction in the nonhuman primate Macaca mulatta activate angiogenic processes in endothelial cells.Treatment with the cytochrome P450 ω-hydroxylase inhibitor HET0016 attenuates cerebrovascular inflammation, oxidative stress and improves vasomotor function in spontaneously hypertensive rats.Resistance to genotoxic stresses in Arctica islandica, the longest living noncolonial animal: is extreme longevity associated with a multistress resistance phenotype?Aging exacerbates microvascular endothelial damage induced by circulating factors present in the serum of septic patients.Aging exacerbates obesity-induced oxidative stress and inflammation in perivascular adipose tissue in mice: a paracrine mechanism contributing to vascular redox dysregulation and inflammation.Aging-induced dysregulation of dicer1-dependent microRNA expression impairs angiogenic capacity of rat cerebromicrovascular endothelial cells.The Somatotropic Axis in Human Aging: Framework for the Current State of Knowledge and Future Research Synergistic effects of hypertension and aging on cognitive function and hippocampal expression of genes involved in β-amyloid generation and Alzheimer's disease.

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Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging

http://www.wikidata.org/entity/Q35845272

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Liver-specific knockdown of IG ...... novel model of vascular aging

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Liver-specific knockdown of IG ...... novel model of vascular aging

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Liver-specific knockdown of IG ...... novel model of vascular aging

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Liver-specific knockdown of IG ...... novel model of vascular aging

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The Journals of Gerontology

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Liver-specific knockdown of IG ...... novel model of vascular aging

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P2093

Akos Koller

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Anna Csiszar

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Caroline Bass

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Danuta Sosnowska

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Jim C Henthorn

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John T Pinto

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Julie Farley

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Lora C Bailey-Downs

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M Noa Valcarcel-Ares

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Matthew Mitschelen

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P2860

Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans

Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

IGF-1, oxidative stress and atheroprotection

Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant response

High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling

Long-lived ames dwarf mice are resistant to chemical stressors

The effects of growth hormone (GH) treatment on GH and insulin/IGF-1 signaling in long-lived Ames dwarf mice

Dermal fibroblasts from long-lived Ames dwarf mice maintain their in vivo resistance to mitochondrial generated reactive oxygen species (ROS)

Effects of growth hormone and thyroxine replacement therapy on insulin signaling in Ames dwarf mice.

Longevity and age-related pathology of mice deficient in pregnancy-associated plasma protein-A.

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313-329

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scholarly article

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10.1093/GERONA/GLR164

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4

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67

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2011-10-21T00:00:00Z

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51736763

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22021391

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3309870

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