Nicotine persistently activates ventral tegmental area dopaminergic neurons via nicotinic acetylcholine receptors containing α4 and α6 subunits.
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Neuronal Nicotinic Acetylcholine Receptor Structure and Function and Response to NicotinePreclinical evidence that activation of mesolimbic alpha 6 subunit containing nicotinic acetylcholine receptors supports nicotine addiction phenotypeDopaminergic and cholinergic learning mechanisms in nicotine addictionNicotine regulates activity of lateral habenula neurons via presynaptic and postsynaptic mechanisms.Low dose nicotine and antagonism of β2 subunit containing nicotinic acetylcholine receptors have similar effects on affective behavior in miceInsights into the neurobiology of the nicotinic cholinergic system and nicotine addiction from mice expressing nicotinic receptors harboring gain-of-function mutationsRole of CB2 cannabinoid receptors in the rewarding, reinforcing, and physical effects of nicotineDifferential expression and function of nicotinic acetylcholine receptors in subdivisions of medial habenulaNeuronal nicotinic acetylcholine receptors: common molecular substrates of nicotine and alcohol dependence.A study of pyrazines in cigarettes and how additives might be used to enhance tobacco addiction.Menthol Alone Upregulates Midbrain nAChRs, Alters nAChR Subtype Stoichiometry, Alters Dopamine Neuron Firing Frequency, and Prevents Nicotine Reward.Nicotine and ethanol cooperate to enhance ventral tegmental area AMPA receptor function via α6-containing nicotinic receptorsA concurrent excitation and inhibition of dopaminergic subpopulations in response to nicotineContributions of β2 subunit-containing nAChRs to chronic nicotine-induced alterations in cognitive flexibility in mice.Acute nicotine administration increases BOLD fMRI signal in brain regions involved in reward signaling and compulsive drug intake in ratsIncreased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawalNicotinic acetylcholine receptors containing α6 subunits contribute to alcohol reward-related behaviours.Anxiolytic-like and anxiogenic-like effects of nicotine are regulated via diverse action at β2*nicotinic acetylcholine receptorsNicotinic acetylcholine receptors containing the α4 subunit modulate alcohol rewardIntravenous nicotine injection induces rapid, experience-dependent sensitization of glutamate release in the ventral tegmental area and nucleus accumbensNicotinic receptor contributions to smoking: insights from human studies and animal modelsNicotine Dependence Reveals Distinct Responses from Neurons and Their Resident Nicotinic Receptors in Medial Habenula.α-Conotoxin PeIA[S9H,V10A,E14N] potently and selectively blocks α6β2β3 versus α6β4 nicotinic acetylcholine receptorsExposure to nicotine increases nicotinic acetylcholine receptor density in the reward pathway and binge ethanol consumption in C57BL/6J adolescent female mice.Ventral tegmental area α6β2 nicotinic acetylcholine receptors modulate phasic dopamine release in the nucleus accumbens core.Positional scanning mutagenesis of α-conotoxin PeIA identifies critical residues that confer potency and selectivity for α6/α3β2β3 and α3β2 nicotinic acetylcholine receptors.Nicotinic acetylcholine receptors containing the α6 subunit contribute to ethanol activation of ventral tegmental area dopaminergic neurons.Long-term nicotine treatment down-regulates α6β2* nicotinic receptor expression and function in nucleus accumbens.Varenicline and cytisine diminish the dysphoric-like state associated with spontaneous nicotine withdrawal in rats.α4α6β2* nicotinic acetylcholine receptor activation on ventral tegmental area dopamine neurons is sufficient to stimulate a depolarizing conductance and enhance surface AMPA receptor functionDiverse strategies targeting α7 homomeric and α6β2* heteromeric nicotinic acetylcholine receptors for smoking cessation.A threshold model for opposing actions of acetylcholine on reward behavior: Molecular mechanisms and implications for treatment of substance abuse disorders.Modulation of ethanol reward sensitivity by nicotinic acetylcholine receptors containing the α6 subunit.Habenula cholinergic neurons regulate anxiety during nicotine withdrawal via nicotinic acetylcholine receptors.Altered nicotine reward-associated behavior following α4 nAChR subunit deletion in ventral midbrain.Effect of Transient Inactivation of Ventral Tegmental Area on the Expression and Acquisition of Nicotine-Induced Conditioned Place Preference in Rats.TC299423, a Novel Agonist for Nicotinic Acetylcholine Receptors.Menthol Enhances Nicotine Reward-Related Behavior by Potentiating Nicotine-Induced Changes in nAChR Function, nAChR Upregulation, and DA Neuron ExcitabilityMultiple CNS nicotinic receptors mediate L-dopa-induced dyskinesias: studies with parkinsonian nicotinic receptor knockout mice.In vitro field potential monitoring on a multi-microelectrode array for the electrophysiological long-term screening of neural stem cell maturation.
P2860
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P2860
Nicotine persistently activates ventral tegmental area dopaminergic neurons via nicotinic acetylcholine receptors containing α4 and α6 subunits.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Nicotine persistently activate ...... containing α4 and α6 subunits.
@ast
Nicotine persistently activate ...... containing α4 and α6 subunits.
@en
type
label
Nicotine persistently activate ...... containing α4 and α6 subunits.
@ast
Nicotine persistently activate ...... containing α4 and α6 subunits.
@en
prefLabel
Nicotine persistently activate ...... containing α4 and α6 subunits.
@ast
Nicotine persistently activate ...... containing α4 and α6 subunits.
@en
P2093
P2860
P356
P1476
Nicotine persistently activate ...... containing α4 and α6 subunits.
@en
P2093
Andrew R Tapper
J Michael McIntosh
Liwang Liu
Paul D Gardner
Rubing Zhao-Shea
P2860
P304
P356
10.1124/MOL.111.076661
P577
2012-01-05T00:00:00Z