about
Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damageThe CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cellsDNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of CancerDNA damage signaling assessed in individual cells in relation to the cell cycle phase and induction of apoptosisChk2 regulates cell cycle progression during mouse oocyte maturation and early embryo developmentNuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuron-like cellsTransgenic mice expressing dominant-negative osmotic-response element-binding protein (OREBP) in lens exhibit fiber cell elongation defect associated with increased DNA breaksThe CHEK2 gene and inherited breast cancer susceptibilityATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeresDNA damage response induced by tobacco smoke in normal human bronchial epithelial and A549 pulmonary adenocarcinoma cells assessed by laser scanning cytometryATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosisTumor suppressor protein kinase Chk2 is a mediator of anoikis of intestinal epithelial cellsCell cycle-dependent localization of CHK2 at centrosomes during mitosis.Linkage disequilibrium mapping of CHEK2: common variation and breast cancer risk.ATM and Chk2 kinase target the p53 cofactor StrapOxidative stress induces cell cycle-dependent Mre11 recruitment, ATM and Chk2 activation and histone H2AX phosphorylation.Mutation of the zebrafish nucleoporin elys sensitizes tissue progenitors to replication stress.Induction of DNA damage response by the supravital probes of nucleic acids.Kinetics of the UV-induced DNA damage response in relation to cell cycle phase. Correlation with DNA replication.Role of the translocation partner in protection against AID-dependent chromosomal translocationsHeterogeneous Family of Cyclomodulins: Smart Weapons That Allow Bacteria to Hijack the Eukaryotic Cell Cycle and Promote Infections.Stabilization of 4E-BP1 by PI3K kinase and its involvement in CHK2 phosphorylation in the cellular response to radiation.The cytolethal distending toxin effects on Mammalian cells: a DNA damage perspective.Analysis of individual molecular events of DNA damage response by flow- and image-assisted cytometryChk2*1100delC Acts in synergy with the Ron receptor tyrosine kinase to accelerate mammary tumorigenesis in mice.Phosphorylation at threonine 288 by cell cycle checkpoint kinase 2 (CHK2) controls human monopolar spindle 1 (Mps1) kinetochore localization.Interdependent phosphorylation within the kinase domain T-loop Regulates CHK2 activityDNA damage signaling is activated during cancer progression in human colorectal carcinoma.The structural determinants of checkpoint activationThe Mek1 phosphorylation cascade plays a role in meiotic recombination of Schizosaccharomyces pombe.Global dissociation of HuR-mRNA complexes promotes cell survival after ionizing radiationThe C. elegans DSB-2 protein reveals a regulatory network that controls competence for meiotic DSB formation and promotes crossover assurance.DNA damage signaling, impairment of cell cycle progression, and apoptosis triggered by 5-ethynyl-2'-deoxyuridine incorporated into DNA.Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage.RNA-binding protein insulin-like growth factor mRNA-binding protein 3 (IMP-3) promotes cell survival via insulin-like growth factor II signaling after ionizing radiation.Checkpoint kinase1 (CHK1) is an important biomarker in breast cancer having a role in chemotherapy responseCellular senescence and cancer chemotherapy resistance.Distinct DNA damage determines differential phosphorylation of Chk2.Repair of topoisomerase I-mediated DNA damage.Chemotherapy induced DNA damage response: convergence of drugs and pathways
P2860
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P2860
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
The Chk2 protein kinase.
@ast
The Chk2 protein kinase.
@en
type
label
The Chk2 protein kinase.
@ast
The Chk2 protein kinase.
@en
prefLabel
The Chk2 protein kinase.
@ast
The Chk2 protein kinase.
@en
P2093
P1433
P1476
The Chk2 protein kinase.
@en
P2093
Carol Prives
Jinwoo Ahn
Marshall Urist
P304
P356
10.1016/J.DNAREP.2004.03.033
P577
2004-08-01T00:00:00Z