Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membrane
about
Epidermal growth factor receptor (EGFR) signaling requires a specific endoplasmic reticulum thioredoxin for the post-translational control of receptor presentation to the cell surfaceThe formation and function of ER-endosome membrane contact sitesEGF receptor trafficking: consequences for signaling and cancerSpatially defined EGF receptor activation reveals an F-actin-dependent phospho-Erk signaling complex.Disruption of clathrin-mediated trafficking causes centrosome overduplication and senescence.Live-cell fluorescence imaging reveals high stoichiometry of Grb2 binding to the EGF receptor sustained during endocytosisDynamin 2-dependent endocytosis is required for normal megakaryocyte development in mice.EGFR endocytosis is a novel therapeutic target in lung cancer with wild-type EGFR.β-Adrenergic receptor-mediated transactivation of epidermal growth factor receptor decreases cardiomyocyte apoptosis through differential subcellular activation of ERK1/2 and Akt.CD24 associates with EGFR and supports EGF/EGFR signaling via RhoA in gastric cancer cells.Epidermal Growth Factor Receptor Cell Proliferation Signaling PathwaysOdin (ANKS1A) modulates EGF receptor recycling and stability.ESCRT-I mediates FLS2 endosomal sorting and plant immunitySecreted protein acidic and rich in cysteine internalization and its age-related alterations in skeletal muscle progenitor cells.The effects of harvesting media on biological characteristics and repair potential of neural stem cells after traumatic brain injury.Drosophila Vps4 promotes Epidermal growth factor receptor signaling independently of its role in receptor degradation.Dynamin2 downregulation delays EGFR endocytic trafficking and promotes EGFR signaling and invasion in hepatocellular carcinoma.Knockdown of GALNT1 suppresses malignant phenotype of hepatocellular carcinoma by suppressing EGFR signalingEpidermal growth factor-stimulated Akt phosphorylation requires clathrin or ErbB2 but not receptor endocytosisPlasma Membrane Organization of Epidermal Growth Factor Receptor in Resting and Ligand-Bound States.Carcinoma cells induce lumen filling and EMT in epithelial cells through soluble E-cadherin-mediated activation of EGFR.Endocytosis separates EGF receptors from endogenous fluorescently labeled HRas and diminishes receptor signaling to MAP kinases in endosomesEssential role for endocytosis in the growth factor-stimulated activation of ERK1/2 in endothelial cells.Regulation of fibroblast growth factor receptor signalling and trafficking by Src and Eps8The Dark Side of Cell Signaling: Positive Roles for Negative Regulators.Leucine-rich repeat and immunoglobulin domain-containing protein-1 (Lrig1) negative regulatory action toward ErbB receptor tyrosine kinases is opposed by leucine-rich repeat and immunoglobulin domain-containing protein 3 (Lrig3).Cathepsin S attenuates endosomal EGFR signalling: A mechanical rationale for the combination of cathepsin S and EGFR tyrosine kinase inhibitors.Lipid sorting and multivesicular endosome biogenesisEffects of membrane trafficking on signaling by receptor tyrosine kinases.Dynamin triple knockout cells reveal off target effects of commonly used dynamin inhibitorsHaploinsufficiency for AAGAB causes clinically heterogeneous forms of punctate palmoplantar keratoderma.Nanoconjugation prolongs endosomal signaling of the epidermal growth factor receptor and enhances apoptosis.Genome-wide co-localization of active EGFR and downstream ERK pathway kinases mirrors mitogen-inducible RNA polymerase 2 genomic occupancy.Reduced annexin A6 expression promotes the degradation of activated epidermal growth factor receptor and sensitizes invasive breast cancer cells to EGFR-targeted tyrosine kinase inhibitors.Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis.Nanoconjugation: A Materials Approach to Enhance Epidermal Growth Factor Induced ApoptosisCortactin promotes colorectal cancer cell proliferation by activating the EGFR-MAPK pathway.Viruses exploit the function of epidermal growth factor receptor.Distinct functions of dynamin isoforms in tumorigenesis and their potential as therapeutic targets in cancer.Multilayered proteomics reveals molecular switches dictating ligand-dependent EGFR trafficking.
P2860
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P2860
Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membrane
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Suppression of EGFR endocytosi ...... imarily at the plasma membrane
@ast
Suppression of EGFR endocytosi ...... imarily at the plasma membrane
@en
type
label
Suppression of EGFR endocytosi ...... imarily at the plasma membrane
@ast
Suppression of EGFR endocytosi ...... imarily at the plasma membrane
@en
prefLabel
Suppression of EGFR endocytosi ...... imarily at the plasma membrane
@ast
Suppression of EGFR endocytosi ...... imarily at the plasma membrane
@en
P2093
P2860
P356
P1476
Suppression of EGFR endocytosi ...... imarily at the plasma membrane
@en
P2093
Hongying Shen
Leiliane P Sousa
Shawn M Ferguson
P2860
P304
P356
10.1073/PNAS.1200164109
P407
P577
2012-02-27T00:00:00Z