ATM-mediated PTEN phosphorylation promotes PTEN nuclear translocation and autophagy in response to DNA-damaging agents in cancer cells - Wikidata - awgldk - TriplyDB

ATM-mediated PTEN phosphorylation promotes PTEN nuclear translocation and autophagy in response to DNA-damaging agents in cancer cells

ATM-mediated PTEN phosphorylation promotes PTEN nuclear translocation and autophagy in response to DNA-damaging agents in cancer cells

http://www.wikidata.org/entity/Q35853239

about

Differential regulatory functions of three classes of phosphatidylinositol and phosphoinositide 3-kinases in autophagy Contribution of classical end-joining to PTEN inactivation in p53-mediated glioblastoma formation and drug-resistant survival.A novel RON splice variant lacking exon 2 activates the PI3K/AKT pathway via PTEN phosphorylation in colorectal carcinoma cells.Fine-Tuning of Pten Localization and Phosphatase Activity Is Essential for Zebrafish Angiogenesis.PTEN Activation by DNA Damage Induces Protective Autophagy in Response to Cucurbitacin B in Hepatocellular Carcinoma Cells.PTEN Reduced UVB-Mediated Apoptosis in Retinal Pigment Epithelium Cells.The critical molecular interconnections in regulating apoptosis and autophagy.Hypoxia-Responsive Mir-301a and Mir-301b Promote Radioresistance of Prostate Cancer Cells via Downregulating NDRG2.Nuclear autophagy: An evolutionarily conserved mechanism of nuclear degradation in the cytoplasm.Autophagy in UV Damage Response.RAD51 regulates CHK1 stability via autophagy to promote cell growth in esophageal squamous carcinoma cells.Modulating Both Tumor Cell Death and Innate Immunity Is Essential for Improving Radiation Therapy Effectiveness.Statin and Bisphosphonate Induce Starvation in Fast-Growing Cancer Cell Lines.Critical Roles of Dual-Specificity Phosphatases in Neuronal Proteostasis and Neurological Diseases.MEK inhibitors block growth of lung tumours with mutations in ataxia-telangiectasia mutated.PTEN Physically Interacts with and Regulates E2F1-mediated Transcription in Lung Cancer.Reactive Oxygen Species, Superoxide Dimutases, and PTEN-p53-AKT-MDM2 Signaling Loop Network in Mesenchymal Stem/Stromal Cells Regulation.Ataxia-Telangiectasia Mutated Kinase Deficiency Impairs Autophagic Response Early During Myocardial Infarction.MicroRNA-22 Promotes Renal Tubulointerstitial Fibrosis by Targeting PTEN and Suppressing Autophagy in Diabetic Nephropathy.Lymphocyte Autophagy in Homeostasis, Activation, and Inflammatory Diseases

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P2860

ATM-mediated PTEN phosphorylation promotes PTEN nuclear translocation and autophagy in response to DNA-damaging agents in cancer cells

http://www.wikidata.org/entity/Q35853239

description

2015 nî lūn-bûn

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2015年の論文

@ja

2015年論文

@yue

2015年論文

@zh-hant

2015年論文

@zh-hk

2015年論文

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2015年論文

@zh-tw

2015年论文

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2015年论文

@zh

2015年论文

@zh-cn

name

ATM-mediated PTEN phosphorylat ...... amaging agents in cancer cells

@ast

ATM-mediated PTEN phosphorylat ...... amaging agents in cancer cells

@en

type

label

ATM-mediated PTEN phosphorylat ...... amaging agents in cancer cells

@ast

ATM-mediated PTEN phosphorylat ...... amaging agents in cancer cells

@en

prefLabel

ATM-mediated PTEN phosphorylat ...... amaging agents in cancer cells

@ast

ATM-mediated PTEN phosphorylat ...... amaging agents in cancer cells

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ATM-mediated PTEN phosphorylat ...... amaging agents in cancer cells

@en

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Dan-Dan Li

http://www.w3.org/2001/XMLSchema#string

Gong-Kan Feng

http://www.w3.org/2001/XMLSchema#string

Jian-Wei Jiang

http://www.w3.org/2001/XMLSchema#string

Jiao Ji

http://www.w3.org/2001/XMLSchema#string

Jing-Hong Chen

http://www.w3.org/2001/XMLSchema#string

Lin Jiao

http://www.w3.org/2001/XMLSchema#string

Peng Zhang

http://www.w3.org/2001/XMLSchema#string

Rong Deng

http://www.w3.org/2001/XMLSchema#string

Wen-Dan Chen

http://www.w3.org/2001/XMLSchema#string

Xiao-Feng Zhu

http://www.w3.org/2001/XMLSchema#string

P2860

The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation

NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN

Ubiquitination regulates PTEN nuclear import and tumor suppression

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

ATM phosphorylates histone H2AX in response to DNA double-strand breaks

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239-252

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scholarly article

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10.1080/15548627.2015.1009767

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2

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25701194

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phosphorylation

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4502816

http://www.w3.org/2001/XMLSchema#string