Novel small molecule α9α10 nicotinic receptor antagonist prevents and reverses chemotherapy-evoked neuropathic pain in rats.
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Conotoxin Interactions with α9α10-nAChRs: Is the α9α10-Nicotinic Acetylcholine Receptor an Important Therapeutic Target for Pain Management?α-conotoxin RgIA protects against the development of nerve injury-induced chronic pain and prevents both neuronal and glial derangementFunctional expression of human α9* nicotinic acetylcholine receptors in X. laevis oocytes is dependent on the α9 subunit 5' UTR.α9-nicotinic acetylcholine receptors contribute to the maintenance of chronic mechanical hyperalgesia, but not thermal or mechanical allodynia.Limited efficacy of α-conopeptides, Vc1.1 and RgIA, to inhibit sensory neuron CaV currentCloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist.Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain.Rodent models of chemotherapy-induced peripheral neuropathy.α9-containing nicotinic acetylcholine receptors and the modulation of pain.RgIA4 Potently Blocks Mouse α9α10 nAChRs and Provides Long Lasting Protection against Oxaliplatin-Induced Cold Allodynia.Comparison crystal structure conformations of two structurally related biphenyl analogues: 4,4'-bis-[3-(pyrrolidin-1-yl)prop-1-yn-1-yl]-1,1'-biphenyl and 4,4'-bis-{3-[(S)-2-methyl-pyrrolidin-1-yl]prop-1-yn-1-yl}-1,1'-biphen-ylCrystal structure of 4,4'-bis-[3-(piperidin-1-yl)prop-1-yn-1-yl]-1,1'-biphen-yl.Comparison of the crystal structures of 4,4'-bis-[3-(4-methyl-piperidin-1-yl)prop-1-yn-1-yl]-1,1'-biphenyl and 4,4'-bis-[3-(2,2,6,6-tetra-methyl-piperidin-1-yl)prop-1-yn-1-yl]-1,1'-biphen-yl.G-Protein Coupled Receptors Targeted by Analgesic Venom Peptides.Nicotinic acetylcholine receptors in neuropathic and inflammatory pain.
P2860
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P2860
Novel small molecule α9α10 nicotinic receptor antagonist prevents and reverses chemotherapy-evoked neuropathic pain in rats.
description
2012 nî lūn-bûn
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2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
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2012年论文
@zh-cn
name
Novel small molecule α9α10 nic ...... oked neuropathic pain in rats.
@ast
Novel small molecule α9α10 nic ...... oked neuropathic pain in rats.
@en
type
label
Novel small molecule α9α10 nic ...... oked neuropathic pain in rats.
@ast
Novel small molecule α9α10 nic ...... oked neuropathic pain in rats.
@en
prefLabel
Novel small molecule α9α10 nic ...... oked neuropathic pain in rats.
@ast
Novel small molecule α9α10 nic ...... oked neuropathic pain in rats.
@en
P2093
P2860
P1476
Novel small molecule α9α10 nic ...... oked neuropathic pain in rats.
@en
P2093
Elzbieta P Wala
J Michael McIntosh
Joseph R Holtman
Peter A Crooks
P2860
P304
P356
10.1213/ANE.0B013E31825A3C72
P407
P577
2012-05-18T00:00:00Z