On the way to targeted therapy of mast cell neoplasms: identification of molecular targets in neoplastic mast cells and evaluation of arising treatment concepts.

On the way to targeted therapy of mast cell neoplasms: identification of molecular targets in neoplastic mast cells and evaluation of arising treatment concepts.

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http://www.wikidata.org/entity/Q35854970
The PI3-kinase/mTOR-targeting drug NVP-BEZ235 inhibits growth and IgE-dependent activation of human mast cells and basophilsSingle nucleotide polymorphism array lesions, TET2, DNMT3A, ASXL1 and CBL mutations are present in systemic mastocytosis.Interleukin-9 (IL-9) and NPM-ALK each generate mast cell hyperplasia as single 'hit' and cooperate in producing a mastocytosis-like disease in mice.Involvement of Fyn kinase in Kit and integrin-mediated Rac activation, cytoskeletal reorganization, and chemotaxis of mast cells.Identification of the Ki-1 antigen (CD30) as a novel therapeutic target in systemic mastocytosis.Mast cells and mastocytosis.Expression of activated STAT5 in neoplastic mast cells in systemic mastocytosis: subcellular distribution and role of the transforming oncoprotein KIT D816V.Identification of bromodomain-containing protein-4 as a novel marker and epigenetic target in mast cell leukemia.Polo-like kinase-1 as a novel target in neoplastic mast cells: demonstration of growth-inhibitory effects of small interfering RNA and the Polo-like kinase-1 targeting drug BI 2536.Aberrant expression of CD30 in neoplastic mast cells in high-grade mastocytosis.H1-receptor antagonists terfenadine and loratadine inhibit spontaneous growth of neoplastic mast cells.Immunohistochemical assessment of CD25 is equally sensitive and diagnostic in mastocytosis compared to flow cytometry.Thalidomide in advanced mastocytosis.Midostaurin: a magic bullet that blocks mast cell expansion and activation.Drug-induced inhibition of phosphorylation of STAT5 overrides drug resistance in neoplastic mast cells.FIP1L1/PDGFRA is a molecular marker of chronic eosinophilic leukaemia but not for systemic mastocytosis.Detection of molecular targets on the surface of CD34+/CD38-- stem cells in various myeloid malignancies.
P2860

On the way to targeted therapy of mast cell neoplasms: identification of molecular targets in neoplastic mast cells and evaluation of arising treatment concepts.

Item
http://www.wikidata.org/entity/Q35854970
description
2004 nî lūn-bûn
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2004年の論文
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2004年論文
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2004年論文
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2004年論文
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2004年論文
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2004年論文
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2004年论文
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2004年论文
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2004年论文
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name
On the way to targeted therapy ...... of arising treatment concepts.
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On the way to targeted therapy ...... of arising treatment concepts.
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type
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On the way to targeted therapy ...... of arising treatment concepts.
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On the way to targeted therapy ...... of arising treatment concepts.
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On the way to targeted therapy ...... of arising treatment concepts.
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On the way to targeted therapy ...... of arising treatment concepts.
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On the way to targeted therapy ...... of arising treatment concepts
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10.1111/J.0960-135X.2004.01369.X
P478
P50
P577
P698
P921