Sustained expression of PGC-1α in the rat nigrostriatal system selectively impairs dopaminergic function. - Wikidata - awgldk - TriplyDB

Sustained expression of PGC-1α in the rat nigrostriatal system selectively impairs dopaminergic function.

Sustained expression of PGC-1α in the rat nigrostriatal system selectively impairs dopaminergic function.

http://www.wikidata.org/entity/Q35856269

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Electron Transport Disturbances and Neurodegeneration: From Albert Szent-Györgyi's Concept (Szeged) till Novel Approaches to Boost Mitochondrial Bioenergetics Mouse models of Parkinson's disease associated with mitochondrial dysfunction New insights into PGC-1 coactivators: redefining their role in the regulation of mitochondrial function and beyond After the banquet: mitochondrial biogenesis, mitophagy, and cell survival Dysregulation of autophagy and mitochondrial function in Parkinson's disease PGC-1α overexpression exacerbates β-amyloid and tau deposition in a transgenic mouse model of Alzheimer's disease.A greatly extended PPARGC1A genomic locus encodes several new brain-specific isoforms and influences Huntington disease age of onset.Pgc-1α overexpression downregulates Pitx3 and increases susceptibility to MPTP toxicity associated with decreased Bdnf.Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization PGC-1α activity in nigral dopamine neurons determines vulnerability to α-synuclein NRF2 promotes neuronal survival in neurodegeneration and acute nerve damage.The Neuroprotective Effect of Tetramethylpyrazine Against Contusive Spinal Cord Injury by Activating PGC-1α in Rats.Thiol-redox signaling, dopaminergic cell death, and Parkinson's disease Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults.A Feed-Forward Circuit of Endogenous PGC-1α and Estrogen Related Receptor α Regulates the Neuronal Electron Transport Chain Lack of Genetic Associations of PPAR-γ and PGC-1α with Alzheimer's Disease and Parkinson's Disease with Dementia.Adult Conditional Knockout of PGC-1α Leads to Loss of Dopamine Neurons.Neuroprotective Properties of a Novel Non-Thiazoledinedione Partial PPAR- γ Agonist against MPTP.PPARγ-coactivator-1α gene transfer reduces neuronal loss and amyloid-β generation by reducing β-secretase in an Alzheimer's disease model.Foxa1 is essential for development and functional integrity of the subthalamic nucleus.Gene Therapy: A Promising Approach for Neuroprotection in Parkinson's Disease?The impact of mitochondrial DNA and nuclear genes related to mitochondrial functioning on the risk of Parkinson's disease.PGC-1α: a master gene that is hard to master.Peroxisome proliferator-activated receptor-γ cofactors in neurodegeneration.Signaling pathway cross talk in Alzheimer's disease PPARγ and PGC-1α as therapeutic targets in Parkinson's.Impaired mitochondrial homeostasis and neurodegeneration: towards new therapeutic targets?The Parkinson Disease Mitochondrial Hypothesis: Where Are We at?Neuroprotective effects of geniposide on Alzheimer's disease pathology.Current disease modifying approaches to treat Parkinson's disease.SUMO-regulated mitochondrial function in Parkinson's disease.PGC-1α controls mitochondrial biogenesis and dynamics in lead-induced neurotoxicity.Gene therapy targeting mitochondrial pathway in Parkinson's disease.Treatments and compositions targeting α-synuclein: a patent review (2010-2016).Regulation of mitochondrial function and endoplasmic reticulum stress by nitric oxide in pluripotent stem cells.Peroxisome proliferator-activated receptor-γ coactivator-1α mediates neuroprotection against excitotoxic brain injury in transgenic mice: role of mitochondria and X-linked inhibitor of apoptosis protein.Caloric Restriction and the Nutrient-Sensing PGC-1α in Mitochondrial Homeostasis: New Perspectives in Neurodegeneration.Overexpression of parkin in the rat nigrostriatal dopamine system protects against methamphetamine neurotoxicity.The Interaction of Mitochondrial Biogenesis and Fission/Fusion Mediated by PGC-1α Regulates Rotenone-Induced Dopaminergic Neurotoxicity.PGC1α: Friend or Foe in Cancer?

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P2860

Sustained expression of PGC-1α in the rat nigrostriatal system selectively impairs dopaminergic function.

http://www.wikidata.org/entity/Q35856269

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

Sustained expression of PGC-1α ...... impairs dopaminergic function.

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Sustained expression of PGC-1α ...... impairs dopaminergic function.

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Sustained expression of PGC-1α ...... impairs dopaminergic function.

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Sustained expression of PGC-1α ...... impairs dopaminergic function.

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Sustained expression of PGC-1α ...... impairs dopaminergic function.

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Human Molecular Genetics

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Sustained expression of PGC-1α ...... impairs dopaminergic function

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C Ciron

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J Dusonchet

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P Aebischer

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S Lengacher

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P2860

PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease

PGC-1 coactivators: inducible regulators of energy metabolism in health and disease

The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis

PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease

PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

Analyzing real-time PCR data by the comparative C(T) method

Superoxide activates mitochondrial uncoupling proteins

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

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1861-1876

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10.1093/HMG/DDR618

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8

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21

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Bernard L. Schneider

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221748591

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