Allostery through the computational microscope: cAMP activation of a canonical signalling domain
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Revealing Atomic-Level Mechanisms of Protein Allostery with Molecular Dynamics SimulationsBridging scales through multiscale modeling: a case study on protein kinase ABridge helix bending promotes RNA polymerase II backtracking through a critical and conserved threonine residueAnalytical methods for structural ensembles and dynamics of intrinsically disordered proteinsEmerging Computational Methods for the Rational Discovery of Allosteric Drugs.Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes.Mapping the Free Energy Landscape of PKA Inhibition and Activation: A Double-Conformational Selection Model for the Tandem cAMP-Binding Domains of PKA RIα.Long-Range Signaling in MutS and MSH Homologs via Switching of Dynamic Communication PathwaysProtein Allostery and Conformational Dynamics.Unidirectional allostery in the regulatory subunit RIα facilitates efficient deactivation of protein kinase A.T7 RNA polymerase translocation is facilitated by a helix opening on the fingers domain that may also prevent backtracking.Modelling proteins' hidden conformations to predict antibiotic resistance.Entropy redistribution controls allostery in a metalloregulatory protein.HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication.Molecular Simulations Reveal an Unresolved Conformation of the Type IA Protein Kinase A Regulatory Subunit and Suggest Its Role in the cAMP Regulatory Mechanism.Electrostatic Interactions as Mediators in the Allosteric Activation of Protein Kinase A RIα.Molecular dynamics simulations on interaction between bacterial proteins: Implication on pathogenic activities.Quantifying Allosteric Communication via Both Concerted Structural Changes and Conformational Disorder with CARDS.Dynamics of the excised base release in thymine DNA glycosylase during DNA repair process.Channeling of cAMP in PDE-PKA Complexes Promotes Signal Adaptation.Insights into the mechanism of the PIK3CA E545K activating mutation using MD simulationsConstructing Markov State Models to elucidate the functional conformational changes of complex biomolecules
P2860
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P2860
Allostery through the computational microscope: cAMP activation of a canonical signalling domain
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
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2015年论文
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name
Allostery through the computat ...... a canonical signalling domain
@ast
Allostery through the computat ...... a canonical signalling domain
@en
type
label
Allostery through the computat ...... a canonical signalling domain
@ast
Allostery through the computat ...... a canonical signalling domain
@en
prefLabel
Allostery through the computat ...... a canonical signalling domain
@ast
Allostery through the computat ...... a canonical signalling domain
@en
P2093
P2860
P356
P1476
Allostery through the computat ...... a canonical signalling domain
@en
P2093
Robert D Malmstrom
Rommie E Amaro
Susan S Taylor
P2860
P2888
P356
10.1038/NCOMMS8588
P407
P577
2015-07-06T00:00:00Z