Activated ALK collaborates with MYCN in neuroblastoma pathogenesis. - Wikidata - awgldk - TriplyDB

Activated ALK collaborates with MYCN in neuroblastoma pathogenesis.

Activated ALK collaborates with MYCN in neuroblastoma pathogenesis.

http://www.wikidata.org/entity/Q35861559

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Drugging MYCN through an allosteric transition in Aurora kinase A The role of the ALK receptor in cancer biology A fresh look at zebrafish from the perspective of cancer research Fascin1-dependent Filopodia are required for directional migration of a subset of neural crest cells The zebrafish as a model for studying neuroblastoma Focal DNA copy number changes in neuroblastoma target MYCN regulated genes Liver-specific expressions of HBx and src in the p53 mutant trigger hepatocarcinogenesis in zebrafish Grouper tshβ promoter-driven transgenic zebrafish marks proximal kidney tubule development Neuroblastoma, a Paradigm for Big Data Science in Pediatric Oncology.Sialic acid metabolic engineering: a potential strategy for the neuroblastoma therapy.Research progress of neuroblastoma related gene variations.Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation.The prenatal origins of cancer Combined ALK and MDM2 inhibition increases antitumor activity and overcomes resistance in human ALK mutant neuroblastoma cell lines and xenograft models.Activated Alk triggers prolonged neurogenesis and Ret upregulation providing a therapeutic target in ALK-mutated neuroblastoma.Zebrafish as a model to assess cancer heterogeneity, progression and relapse.CDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells.The pre-rRNA processing factor DEF is rate limiting for the pathogenesis of MYCN-driven neuroblastoma.Wild-type ALK and activating ALK-R1275Q and ALK-F1174L mutations upregulate Myc and initiate tumor formation in murine neural crest progenitor cells Zebrafish cancer: the state of the art and the path forward.ALK-driven tumors and targeted therapy: focus on crizotinib Neuroblastoma patient-derived orthotopic xenografts retain metastatic patterns and geno- and phenotypes of patient tumours.A recurrent neomorphic mutation in MYOD1 defines a clinically aggressive subset of embryonal rhabdomyosarcoma associated with PI3K-AKT pathway mutations.Anaplastic lymphoma kinase is required for neurogenesis in the developing central nervous system of zebrafish.Generation of murine sympathoadrenergic progenitor-like cells from embryonic stem cells and postnatal adrenal glands.Comparative oncogenomic analysis of copy number alterations in human and zebrafish tumors enables cancer driver discovery Intrinsic susceptibility MRI identifies tumors with ALKF1174L mutation in genetically-engineered murine models of high-risk neuroblastoma Neuroblastoma: developmental biology, cancer genomics and immunotherapy.Mosaic zebrafish transgenesis for functional genomic analysis of candidate cooperative genes in tumor pathogenesis.Ascl1 phospho-status regulates neuronal differentiation in a Xenopus developmental model of neuroblastoma Expression of MYCN in Multipotent Sympathoadrenal Progenitors Induces Proliferation and Neural Differentiation, but Is Not Sufficient for Tumorigenesis.ALK and MYCN: when two oncogenes are better than one.Efficient transgenesis mediated by pigmentation rescue in zebrafish The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastoma Preclinical Models Provide Scientific Justification and Translational Relevance for Moving Novel Therapeutics into Clinical Trials for Pediatric Cancer.Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions The Zebrafish as a Tool to Cancer Drug Discovery.Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish.Neuroblastoma and MYCN Sam68 is a novel marker for aggressive neuroblastoma.

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P2860

Activated ALK collaborates with MYCN in neuroblastoma pathogenesis.

http://www.wikidata.org/entity/Q35861559

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2012年论文

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2012年论文

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name

Activated ALK collaborates with MYCN in neuroblastoma pathogenesis.

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Activated ALK collaborates with MYCN in neuroblastoma pathogenesis.

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Activated ALK collaborates with MYCN in neuroblastoma pathogenesis.

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Activated ALK collaborates with MYCN in neuroblastoma pathogenesis.

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Activated ALK collaborates with MYCN in neuroblastoma pathogenesis.

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Activated ALK collaborates with MYCN in neuroblastoma pathogenesis.

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Activated ALK collaborates with MYCN in neuroblastoma pathogenesis

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A Thomas Look

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Antonio R Perez-Atayde

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Daniel Helman

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Donna S Neuberg

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Feng Guo

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Jeffery L Kutok

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Jeong-Soo Lee

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Jimann Shin

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John P Kanki

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Rani E George

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P2860

Anaplastic lymphoma kinase: signalling in development and disease

Identification of ALK as a major familial neuroblastoma predisposition gene

Activating mutations in ALK provide a therapeutic target in neuroblastoma.

Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer.

Crizotinib in ALK-rearranged inflammatory myofibroblastic tumor.

The neuroblastoma-associated F1174L ALK mutation causes resistance to an ALK kinase inhibitor in ALK-translocated cancers

Stages of embryonic development of the zebrafish

Myc pathways provoking cell suicide and cancer

Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma

Molecular pathogenesis of peripheral neuroblastic tumors

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