Gates, Channels, and Switches: Elements of the Proteasome Machine
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The life cycle of the 26S proteasome: from birth, through regulation and function, and onto its deathHow Polyomaviruses Exploit the ERAD Machinery to Cause InfectionAn atomic structure of the human 26S proteasomeInsecticidal Activity of Melaleuca alternifolia Essential Oil and RNA-Seq Analysis of Sitophilus zeamais Transcriptome in Response to Oil FumigationStructure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targetsRpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasomeOpen-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradationStructure of an endogenous yeast 26S proteasome reveals two major conformational statesThe Proteasome Ubiquitin Receptor hRpn13 and Its Interacting Deubiquitinating Enzyme Uch37 Are Required for Proper Cell Cycle ProgressionPhosphorylation of the C-terminal tail of proteasome subunit α7 is required for binding of the proteasome quality control factor Ecm29.Characterization of Dynamic UbR-Proteasome Subcomplexes by In vivo Cross-linking (X) Assisted Bimolecular Tandem Affinity Purification (XBAP) and Label-free Quantitation.Conserved Sequence Preferences Contribute to Substrate Recognition by the Proteasome.Structure of the human 26S proteasome at a resolution of 3.9 Å.Monoubiquitination in proteasomal degradation.p62- and ubiquitin-dependent stress-induced autophagy of the mammalian 26S proteasome.Structural basis for dynamic regulation of the human 26S proteasome.Gyre and gimble in the proteasome.Reversible phosphorylation of the 26S proteasome.High-resolution cryo-EM structure of the proteasome in complex with ADP-AlFx.Ubiquitin recognition by the proteasome.Mass Spectrometry: A Technique of Many Faces.Proteasome expression and activity in cancer and cancer stem cells.Ubiquitin C-terminal hydrolase-L1 (UCH-L1) as a therapeutic and diagnostic target in neurodegeneration, neurotrauma and neuro-injuries.Monoubiquitination joins polyubiquitination as an esteemed proteasomal targeting signal.The Logic of the 26S Proteasome.Protein Degradation Systems as Antimalarial Therapeutic Targets.Mycobacterium tuberculosis proteasomal ATPase Mpa has a β-grasp domain that hinders docking with the proteasome core protease.Bimodal antagonism of PKA signalling by ARHGAP36.An assay for 26S proteasome activity based on fluorescence anisotropy measurements of dye-labeled protein substratesStructures of Rpn1 T1:Rad23 and hRpn13:hPLIC2 Reveal Distinct Binding Mechanisms between Substrate Receptors and Shuttle Factors of the Proteasome.Ubiquitinated proteins promote the association of proteasomes with the deubiquitinating enzyme Usp14 and the ubiquitin ligase Ube3c.Electrostatic Map Of Proteasome α-Rings Encodes The Design of Allosteric Porphyrin-Based Inhibitors Able To Affect 20S Conformation By Cooperative Binding.Small Molecule Enhancement of 20S Proteasome Activity Targets Intrinsically Disordered Proteins.Structural insights on the dynamics of proteasome formation.Probing the cooperativity of Thermoplasma acidophilum proteasome core particle gating by NMR spectroscopy.Regulating protein breakdown through proteasome phosphorylation.Deubiquitylating enzymes and drug discovery: emerging opportunities.In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment.Proteasome substrate capture and gate opening by the accessory factor PafE from Mycobacterium tuberculosis.MAPK signaling couples SCF-mediated degradation of translational regulators to oocyte meiotic progression.
P2860
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P2860
Gates, Channels, and Switches: Elements of the Proteasome Machine
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Gates, Channels, and Switches: Elements of the Proteasome Machine
@ast
Gates, Channels, and Switches: Elements of the Proteasome Machine
@en
type
label
Gates, Channels, and Switches: Elements of the Proteasome Machine
@ast
Gates, Channels, and Switches: Elements of the Proteasome Machine
@en
prefLabel
Gates, Channels, and Switches: Elements of the Proteasome Machine
@ast
Gates, Channels, and Switches: Elements of the Proteasome Machine
@en
P2093
P2860
P1476
Gates, Channels, and Switches: Elements of the Proteasome Machine
@en
P2093
Daniel Finley
Kylie J Walters
Xiang Chen
P2860
P356
10.1016/J.TIBS.2015.10.009
P577
2015-11-28T00:00:00Z