Identification of latent membrane protein 2A (LMP2A) domains essential for the LMP2A dominant-negative effect on B-lymphocyte surface immunoglobulin signal transduction - Wikidata - awgldk - TriplyDB

Identification of latent membrane protein 2A (LMP2A) domains essential for the LMP2A dominant-negative effect on B-lymphocyte surface immunoglobulin signal transduction

Identification of latent membrane protein 2A (LMP2A) domains essential for the LMP2A dominant-negative effect on B-lymphocyte surface immunoglobulin signal transduction

http://www.wikidata.org/entity/Q35868359

about

Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases Dual stimulation of Epstein-Barr Virus (EBV)-specific CD4+- and CD8+-T-cell responses by a chimeric antigen construct: potential therapeutic vaccine for EBV-positive nasopharyngeal carcinoma Epstein-Barr virus latent membrane protein 2A (LMP2A) employs the SLP-65 signaling module The EBV nuclear antigen 1 (EBNA1) enhances B cell immortalization several thousandfold Identification of the novel K15 gene at the rightmost end of the Kaposi's sarcoma-associated herpesvirus genome.Agammaglobulinemia associated with BCR⁻ B cells and enhanced expression of CD19 The LMP2A ITAM is essential for providing B cells with development and survival signals in vivo EBV LMP2A provides a surrogate pre-B cell receptor signal through constitutive activation of the ERK/MAPK pathway.Modulation of the cell growth regulator mTOR by Epstein-Barr virus-encoded LMP2A.Tyrosine 112 of latent membrane protein 2A is essential for protein tyrosine kinase loading and regulation of Epstein-Barr virus latency Latent membrane protein 2A-mediated effects on the phosphatidylinositol 3-Kinase/Akt pathway.Epithelial cell adhesion to extracellular matrix proteins induces tyrosine phosphorylation of the Epstein-Barr virus latent membrane protein 2: a role for C-terminal Src kinase.PY motifs of Epstein-Barr virus LMP2A regulate protein stability and phosphorylation of LMP2A-associated proteins.C-terminal domain of the Epstein-Barr virus LMP2A membrane protein contains a clustering signal Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation.Pathogenetic importance and therapeutic implications of NF-κB in lymphoid malignancies.The genetic approach to the Epstein-Barr virus: from basic virology to gene therapy.A novel latent membrane 2 transcript expressed in Epstein-Barr virus-positive NK- and T-cell lymphoproliferative disease encodes a target for cellular immunotherapy.Itchy, a Nedd4 ubiquitin ligase, downregulates latent membrane protein 2A activity in B-cell signaling.Length of Epstein-Barr virus termini as a determinant of epithelial cell clonal emergence Epstein-Barr virus latent-infection membrane proteins are palmitoylated and raft-associated: protein 1 binds to the cytoskeleton through TNF receptor cytoplasmic factors.Epstein-barr virus latent membrane protein 2B (LMP2B) modulates LMP2A activity.K1 protein of human herpesvirus 8 suppresses lymphoma cell Fas-mediated apoptosis Cholesterol is critical for Epstein-Barr virus latent membrane protein 2A trafficking and protein stability Epstein-Barr virus latent membrane protein 2A mediates transformation through constitutive activation of the Ras/PI3-K/Akt Pathway.Dasatinib therapy results in decreased B cell proliferation, splenomegaly, and tumor growth in a murine model of lymphoma expressing Myc and Epstein-Barr virus LMP2A.Latent membrane protein 2B regulates susceptibility to induction of lytic Epstein-Barr virus infection An auto-regulatory loop for EBV LMP2A involves activation of Notch.Epstein-Barr virus latent membrane protein 2A preferentially signals through the Src family kinase Lyn Latent membrane protein 2A inhibits transforming growth factor-beta 1-induced apoptosis through the phosphatidylinositol 3-kinase/Akt pathway.Epstein-Barr virus LMP2A bypasses p53 inactivation in a MYC model of lymphomagenesis.The c-Cbl proto-oncoprotein downregulates EBV LMP2A signaling.Induction of therapeutic antibodies by vaccination against external loops of tumor-associated viral latent membrane protein.LMP2A does not require palmitoylation to localize to buoyant complexes or for function.Role of the immunoreceptor tyrosine-based activation motif of latent membrane protein 2A (LMP2A) in Epstein-Barr virus LMP2A-induced cell transformation.Epstein-Barr virus latent membrane protein 2A contributes to anoikis resistance through ERK activation.Epstein-Barr virus represses the FoxO1 transcription factor through latent membrane protein 1 and latent membrane protein 2A The YXXL sequences of a transmembrane protein of bovine leukemia virus are required for viral entry and incorporation of viral envelope protein into virions.Epstein-Barr virus LMP2A transforms epithelial cells, inhibits cell differentiation, and activates Akt.Identification of a spliced gene from Kaposi's sarcoma-associated herpesvirus encoding a protein with similarities to latent membrane proteins 1 and 2A of Epstein-Barr virus

P2860

Q24515076-C0AD8194-24DB-4D67-A816-C0B1C6A2B46A Q24610485-105EEACF-30FD-4C4C-A41F-C7C4511BC308 Q24675538-A343E65A-D20B-4BE4-B872-CE6688403C3B Q24685733-3C8310B7-A70B-4F53-9D88-E4E66ADD9824 Q30175290-F4CFF470-0D37-4125-AC88-CCF51AF2FAFF Q30425512-DBC54811-CE7E-4C8C-8DFE-B66F146FD3C8 Q33604616-83B989BF-E1CA-40EB-B24F-B5B8275F0EFD Q33739672-8DC98BE4-65A3-435C-A4D3-FC22C06CF865 Q33754907-EA03F6A8-6010-4E41-9EB5-BAEEA918CF6C Q33784647-6578AD90-BE74-4044-AE8E-8846565A947E Q33787396-487A65E8-41C8-4D94-AFE5-C62A7D67E4B3 Q33813796-3841AB65-65DC-4993-A44F-DF66684051DB Q33842129-1B4BB1C1-B4B2-4932-8EA4-03B105F45DA7 Q33849076-3FCB3A8D-CB66-412E-9A1F-175E57FBF47C Q33888592-2D5724D5-2B0C-4EC0-AE37-0F4618F0916E Q33889168-DCC9B3DF-0236-4749-A40C-81FCB1F09E94 Q33918592-304CA5C7-C3F5-49AD-A377-667512004111 Q34310840-D6048C79-2933-4410-BCC3-C1709034F552 Q34975783-39007A61-B3D1-442F-98C7-CCC55FAAB7B9 Q35155351-59B2D91F-4DF8-4429-85E2-9F5F563A503D Q35291650-930319BA-6FBF-4643-8DE9-4E080BB9E117 Q35634286-1172644E-D5F5-412E-9806-E95E718FF000 Q35642734-EA533DF5-E9AA-4A0E-B750-659D262923ED Q35793738-B76F0C3A-D25A-40B0-B33E-EBD049DAA1BF Q35948025-EDDE9A33-6A5A-4350-99FF-DEC4E0EE7D23 Q36040966-2F9ED200-21ED-47E8-BBBC-37C3B3D01C6E Q36483287-B0E853FF-0B6F-41E2-B4A8-8929C06B041F Q36528115-DA046F6A-6B5B-4DA1-AE75-F48EBD8680D9 Q36845865-F6E11523-70AD-44DC-A6A0-5718ACCC7088 Q36961820-08E834AD-04AB-4249-B872-DFCE497056CF Q37394390-6B0AD25F-FDFB-42E2-8FF0-E89FC847FE83 Q37400412-69CFCCCD-5765-47F4-AA1B-24C4835B679A Q37410691-8F760265-2B0B-41A2-8815-3D0AC605A365 Q37567931-3DB0E491-6769-4A51-841F-C76B2D1025E7 Q38860330-7F947823-9396-4E05-8BAE-833C6E99E440 Q39148562-01B4873D-8CAB-4EC7-9DCB-26195644CBEB Q39304933-3AF7F6B3-A51F-4A66-B383-FCC1D42700D2 Q39549376-EFEBB9F9-B337-4DA1-9E07-4F991AD50B0C Q39585482-8DDBFEE1-53F2-41E9-9F94-60A73CE9082B Q39595507-4DDC3304-D802-4592-8E11-4B12767274A1

P2860

Identification of latent membrane protein 2A (LMP2A) domains essential for the LMP2A dominant-negative effect on B-lymphocyte surface immunoglobulin signal transduction

http://www.wikidata.org/entity/Q35868359

description

1996 nî lūn-bûn

@nan

1996年の論文

@ja

1996年論文

@yue

1996年論文

@zh-hant

1996年論文

@zh-hk

1996年論文

@zh-mo

1996年論文

@zh-tw

1996年论文

@wuu

1996年论文

@zh

1996年论文

@zh-cn

name

Identification of latent membr ...... noglobulin signal transduction

@ast

Identification of latent membr ...... noglobulin signal transduction

@en

type

label

Identification of latent membr ...... noglobulin signal transduction

@ast

Identification of latent membr ...... noglobulin signal transduction

@en

prefLabel

Identification of latent membr ...... noglobulin signal transduction

@ast

Identification of latent membr ...... noglobulin signal transduction

@en

P1433

Q35868359-BD12BEF9-9EB9-45CC-BD8C-89908E61A82C

P1476

Q35868359-687733A1-05AF-420F-9CEE-C9BF9AFD94EE

P2093

Q35868359-256B6446-7F8B-4168-B37F-6AF97DCC7F68

Q35868359-2C08FD06-316D-4CE0-A917-FAA5441E7C9E

Q35868359-691E54E9-1B17-48E9-93DA-8F33FFF9A812

Q35868359-7C510F92-E477-4200-9316-55129D260EDF

Q35868359-B342A198-8120-4950-B458-D16C58A30BEC

Q35868359-BC520661-8862-4093-BA55-FF6AA294EAA5

Q35868359-F63F893F-6C16-461D-82F2-86D79FA4909E

Q35868359-FCC68FCD-665B-4899-BD6F-D1D21D3E010D

P2860

Q35868359-03A89104-2910-4050-9B0D-B65203B786F1

Q35868359-0BB20D38-E621-4FD5-8804-43DE503B8CE7

Q35868359-143B2A08-E64B-481E-A260-4FA92403338C

Q35868359-14B73E76-A33A-47F5-B38A-C9657AD23402

Q35868359-18362F16-8743-44A5-8800-B12066259BDC

Q35868359-2D637C65-2889-4BF4-AA56-0B01C9803A8B

Q35868359-33A1A7CF-D27D-4105-A38C-574E5FEB75CE

Q35868359-377224AF-4BBD-42A5-B022-0F32178DA9D2

Q35868359-4314F628-6FB1-43AB-BC72-6858236D0193

Q35868359-4B51002E-C1C0-468F-A5A3-0D1EBA6AA080

P304

Q35868359-680411E8-7EE7-42EF-B30D-97060817897E

P31

Q35868359-070607C4-ADF0-4A3D-8139-ECE35FD40A9D

P407

Q35868359-8D74DC1A-460B-4914-B30E-022CFEAA0B7B

P433

Q35868359-193CAB8C-2A2D-4945-A9A8-98F15590F1B0

P478

Q35868359-BD80792A-3D89-475A-BA9F-4CE6F5412710

P577

Q35868359-D338EA74-BC4C-4470-811F-063A3252437E

P698

Q35868359-B11AE67F-8CB9-4FC4-A51C-237E35F90FD1

P932

Q35868359-121ED1FF-D1F1-41E3-90A8-B8E59B8277D4

P1433

Journal of Virology

P1476

Identification of latent membr ...... noglobulin signal transduction

@en

P2093

B Frech

http://www.w3.org/2001/XMLSchema#string

E Kremmer

http://www.w3.org/2001/XMLSchema#string

F A Grässer

http://www.w3.org/2001/XMLSchema#string

G Laux

http://www.w3.org/2001/XMLSchema#string

R Herrold

http://www.w3.org/2001/XMLSchema#string

R Longnecker

http://www.w3.org/2001/XMLSchema#string

S Fruehling

http://www.w3.org/2001/XMLSchema#string

S K Lee

http://www.w3.org/2001/XMLSchema#string

P2860

The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules

An Epstein-Barr virus transformation-associated membrane protein interacts with src family tyrosine kinases

SH2 domains recognize specific phosphopeptide sequences

Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav

Signal transduction by lymphocyte antigen receptors

High-expression vectors with multiple cloning sites for construction of trpE fusion genes: pATH vectors

Proteins with SH2 and SH3 domains couple receptor tyrosine kinases to intracellular signalling pathways.

Identification of Epstein-Barr virus terminal protein 1 (TP1) in extracts of four lymphoid cell lines, expression in insect cells, and detection of antibodies in human sera

Signal transduction--a conserved pathway from the membrane to the nucleus.

P304

6216-6226

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P407

P433

9

http://www.w3.org/2001/XMLSchema#string

P478

70

http://www.w3.org/2001/XMLSchema#string

P577

1996-09-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

8709248

http://www.w3.org/2001/XMLSchema#string

P932

190646

http://www.w3.org/2001/XMLSchema#string