The KCa3.1 blocker TRAM-34 reduces infarction and neurological deficit in a rat model of ischemia/reperfusion stroke.
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Fluid and ion transfer across the blood-brain and blood-cerebrospinal fluid barriers; a comparative account of mechanisms and rolesCa(2+)-activated K(+) channel-3.1 blocker TRAM-34 attenuates airway remodeling and eosinophilia in a murine asthma model.Targeted inhibition of KCa3.1 attenuates TGF-β-induced reactive astrogliosis through the Smad2/3 signaling pathway.KCa3.1 modulates neuroblast migration along the rostral migratory stream (RMS) in vivo.NS6180, a new K(Ca) 3.1 channel inhibitor prevents T-cell activation and inflammation in a rat model of inflammatory bowel disease.Genetic KCa3.1-deficiency produces locomotor hyperactivity and alterations in cerebral monoamine levelsThe Ca²⁺-activated K⁺ channel KCa3.1 as a potential new target for the prevention of allograft vasculopathy.Kcnn4 is a regulator of macrophage multinucleation in bone homeostasis and inflammatory diseaseMicroglial KCa3.1 Channels as a Potential Therapeutic Target for Alzheimer's DiseaseGenetic deficit of KCa 3.1 channels protects against pulmonary circulatory collapse induced by TRPV4 channel activation.Protective Roles for Potassium SK/K(Ca)2 Channels in Microglia and Neurons.Ion channels in innate and adaptive immunityKCa3.1 inhibition switches the phenotype of glioma-infiltrating microglia/macrophagesKCa3.1 channels are involved in the infiltrative behavior of glioblastoma in vivo.The potassium channel KCa3.1 as new therapeutic target for the prevention of obliterative airway disease.KCa3.1 channel inhibition sensitizes malignant gliomas to temozolomide treatment.Development of a QPatch automated electrophysiology assay for identifying KCa3.1 inhibitors and activators.K(Ca)2 and k(ca)3 channels in learning and memory processes, and neurodegeneration.Endothelial small-conductance and intermediate-conductance KCa channels: an update on their pharmacology and usefulness as cardiovascular targets.T-type channels buddy up.Role of the potassium channel KCa3.1 in diabetic nephropathy.The two-pore domain potassium channel KCNK5 deteriorates outcome in ischemic neurodegeneration.Calcium-activated potassium channels in ischemia reperfusion: a brief update.KCa3.1 (IK) modulates pancreatic cancer cell migration, invasion and proliferation: anomalous effects on TRAM-34.KCa 3.1-a microglial target ready for drug repurposing?Potassium channel expression and function in microglia: Plasticity and possible species variations.Microglial SK3 and SK4 currents and activation state are modulated by the neuroprotective drug, riluzole.KCa3.1 Channel Modulators as Potential Therapeutic Compounds for Glioblastoma.Functional roles of the Ca2+-activated K+ channel, KCa3.1, in brain tumors.IL-4 type 1 receptor signaling up-regulates KCNN4 expression, and increases the KCa3.1 current and its contribution to migration of alternative-activated microglia.Differential Kv1.3, KCa3.1, and Kir2.1 expression in "classically" and "alternatively" activated microglia.Blood-brain barrier KCa3.1 channels: evidence for a role in brain Na uptake and edema in ischemic stroke.Ion channels in control of pancreatic stellate cell migration.Neuronal expression of the intermediate conductance calcium-activated potassium channel KCa3.1 in the mammalian central nervous system.The potassium channel KCa3.1 constitutes a pharmacological target for neuroinflammation associated with ischemia/reperfusion stroke.Treatment with the KCa3.1 inhibitor TRAM-34 during diabetic ketoacidosis reduces inflammatory changes in the brain.Senicapoc: Repurposing a Drug to Target Microglia KCa3.1 in Stroke.Quantification of the functional expression of the Ca2+ -activated K+ channel KCa 3.1 on microglia from adult human neocortical tissue.Inhibition of the potassium channel Kv1.3 reduces infarction and inflammation in ischemic stroke.
P2860
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P2860
The KCa3.1 blocker TRAM-34 reduces infarction and neurological deficit in a rat model of ischemia/reperfusion stroke.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
The KCa3.1 blocker TRAM-34 red ...... f ischemia/reperfusion stroke.
@ast
The KCa3.1 blocker TRAM-34 red ...... f ischemia/reperfusion stroke.
@en
type
label
The KCa3.1 blocker TRAM-34 red ...... f ischemia/reperfusion stroke.
@ast
The KCa3.1 blocker TRAM-34 red ...... f ischemia/reperfusion stroke.
@en
prefLabel
The KCa3.1 blocker TRAM-34 red ...... f ischemia/reperfusion stroke.
@ast
The KCa3.1 blocker TRAM-34 red ...... f ischemia/reperfusion stroke.
@en
P2093
P2860
P356
P1476
The KCa3.1 blocker TRAM-34 red ...... f ischemia/reperfusion stroke.
@en
P2093
Girija Raman
Heike Wulff
Martha E O'Donnell
Silke Bodendiek
Yi-Je Chen
P2860
P304
P356
10.1038/JCBFM.2011.101
P577
2011-07-13T00:00:00Z