Investigation of miscellaneous hERG inhibition in large diverse compound collection using automated patch-clamp assay.

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The High Cost of Stroke and Stroke Cytoprotection Research.Compilation and physicochemical classification analysis of a diverse hERG inhibition database.Development of Safe Drugs: The hERG Challenge.Ion channels research in the post-genomic era.

P2860

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P2860

Investigation of miscellaneous hERG inhibition in large diverse compound collection using automated patch-clamp assay.

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Investigation of miscellaneous ...... g automated patch-clamp assay.

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Investigation of miscellaneous ...... g automated patch-clamp assay.

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Investigation of miscellaneous ...... g automated patch-clamp assay.

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Investigation of miscellaneous ...... g automated patch-clamp assay.

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Bei-yan Zou

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Hai-bo Yu

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Min Li

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Xiao-liang Wang

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P2860

A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

Discovery of a series of 2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as novel molecular switches that modulate modes of K(v)7.2 (KCNQ2) channel pharmacology: identification of (S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a po

Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator

Discovery, Synthesis, and Structure–Activity Relationship of a Series of N -Aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener

Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes

hERG channel function: beyond long QT

Translational toxicology and rescue strategies of the hERG channel dysfunction: biochemical and molecular mechanistic aspects

Global analysis reveals families of chemical motifs enriched for HERG inhibitors

ADMET evaluation in drug discovery. 12. Development of binary classification models for prediction of hERG potassium channel blockage

Evaluation of an in silico cardiac safety assay: using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge.

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aps.2015.143

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10.1038/APS.2015.143

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Investigation of miscellaneous hERG inhibition in large diverse compound collection using automated patch-clamp assay.

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P2860

P2860

Investigation of miscellaneous hERG inhibition in large diverse compound collection using automated patch-clamp assay.

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